Methylenetetrahydrofolate Reductase (MTHFR) (C677T and A1298C) Polymorphisms and Vascular Complications in Patients with Type 2 Diabetes

To assess whether 2 polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C, are risk factors for vascular complications in Tunisian patients with type 2 diabetes mellitus. The MTHFR polymorphisms were genotyped, and plasma homocysteine levels were evaluated in 160 Tu...

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Veröffentlicht in:	Canadian journal of diabetes 2017-08, Vol.41 (4), p.366-371
Hauptverfasser:	Fekih-Mrissa, Najiba, Mrad, Meriem, Ibrahim, Hazard, Akremi, Imen, Sayeh, Aicha, Jaidane, Amel, Ouertani, Haroun, Zidi, Borni, Gritli, Nasreddine
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult complications vasculaires Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - genetics Diabetic Retinopathy - epidemiology Diabetic Retinopathy - genetics diabète sucré de type 2 Female genetic predisposition gène MTHFR homocystein homocystéine Humans Hypertension - epidemiology Hypertension - genetics Male Methylenetetrahydrofolate Reductase (NADPH2) - genetics Middle Aged MTHFR gene Polymorphism, Single Nucleotide - genetics prédisposition génétique type 2 diabetes mellitus vascular complications Vascular Diseases - epidemiology Vascular Diseases - genetics
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Zusammenfassung:	To assess whether 2 polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C, are risk factors for vascular complications in Tunisian patients with type 2 diabetes mellitus. The MTHFR polymorphisms were genotyped, and plasma homocysteine levels were evaluated in 160 Tunisian patients with type 2 diabetes mellitus. Prevalence of the 2 heterozygous polymorphisms of the thermolabile MTHFR gene (CT and AC) was encountered more commonly in patients with diabetes mellitus than in the healthy controls (p
ISSN:	1499-2671 2352-3840
DOI:	10.1016/j.jcjd.2016.11.007