Functional properties of the N-terminal region of progesterone receptors and their mechanistic relationship to structure

Progesterone receptors (PR) are present in two isoforms, PR-A and PR-B. The B-upstream segment (BUS) of PR-B is a 164 amino acid N-terminal extension that is missing in PR-A and is responsible for the functional differences reported between the two isoforms. BUS contains an activation function (AF3)...

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Veröffentlicht in:	Journal of steroid biochemistry and molecular biology 2003-06, Vol.85 (2), p.209-219
Hauptverfasser:	Takimoto, Glenn S, Tung, Lin, Abdel-Hafiz, Hany, Abel, Michael G, Sartorius, Carol A, Richer, Jennifer K, Jacobsen, Britta M, Bain, David L, Horwitz, Kathryn B
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation domain Amino Acid Sequence Animals Binding Sites Biological and medical sciences Cell receptors Cell structures and functions Cercopithecus aethiops Cofactors COS Cells Fundamental and applied biological sciences. Psychology HeLa Cells Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors Humans Molecular and cellular biology Molecular Sequence Data Mutagenesis Peptide Fragments - chemistry Progesterone receptor Protein Isoforms - chemistry Protein Isoforms - physiology Receptors, Progesterone - chemistry Receptors, Progesterone - genetics Receptors, Progesterone - physiology Recombinant Proteins - chemistry Recombinant Proteins - metabolism Repression Sequence Alignment Sequence Homology, Amino Acid Structure SUMO Synergism Transcription Transcription, Genetic Transfection
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