Effects of metals Cu, Fe, Ni, V, and Zn on rat lung epithelial cells
Inhalation of combustion-derived particulate matter can have a variety of negative impacts on human health. Metals are known to play a substantial role in these effects, however, the interactions between cellular responses caused by multiple metals is not well understood. The impact of metals (Zn, C...
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| Veröffentlicht in: | Toxicology (Amsterdam) 2003-08, Vol.190 (3), p.171-184 |
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| creator | Riley, Mark R. Boesewetter, Dianne E. Kim, Aana M. Sirvent, Francisco P. |
| description | Inhalation of combustion-derived particulate matter can have a variety of negative impacts on human health. Metals are known to play a substantial role in these effects, however, the interactions between cellular responses caused by multiple metals is not well understood. The impact of metals (Zn, Cu, Ni, V, and Fe) individually and in combination on a rat lung epithelial cell line (RLE-6TN) was evaluated. Quantifications involved measurement of inhibition of cell culture metabolism (mitochondrial succinate dehydrogenase activity), cell death, mechanisms of cell death, and cytokine secretion. The ranking of metal toxicity based on TC
50 values is V>Zn>Cu>Ni>Fe. Interactions were observed for exposures containing multiple metals: Zn+V, Zn+Cu, Zn+Fe, and Zn+Ni. Zn appears to diminish the negative impact of V and Cu; has an additive effect with Ni, and has no substantial effect on Fe toxicity. |
| doi_str_mv | 10.1016/S0300-483X(03)00162-8 |
| format | Article |
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50 values is V>Zn>Cu>Ni>Fe. Interactions were observed for exposures containing multiple metals: Zn+V, Zn+Cu, Zn+Fe, and Zn+Ni. Zn appears to diminish the negative impact of V and Cu; has an additive effect with Ni, and has no substantial effect on Fe toxicity.</description><identifier>ISSN: 0300-483X</identifier><identifier>EISSN: 1879-3185</identifier><identifier>DOI: 10.1016/S0300-483X(03)00162-8</identifier><identifier>PMID: 12927373</identifier><identifier>CODEN: TXICDD</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Air Pollutants - toxicity ; Animals ; Biological and medical sciences ; Cell death ; Cell Death - drug effects ; Cells, Cultured ; Chemical and industrial products toxicology. Toxic occupational diseases ; Copper - metabolism ; Copper - toxicity ; Epithelial cell ; Epithelial Cells - cytology ; Epithelial Cells - drug effects ; Epithelial Cells - metabolism ; Formazans - metabolism ; Interleukin-6 - metabolism ; Iron - metabolism ; Iron - toxicity ; Lung - cytology ; Lung - drug effects ; Lung - metabolism ; Medical sciences ; Metals and various inorganic compounds ; Metals, Heavy - toxicity ; Microscopy, Fluorescence ; Nickel - metabolism ; Nickel - toxicity ; Particulate matter ; Rats ; Succinate Dehydrogenase - metabolism ; Tetrazolium Salts - metabolism ; Toxicology ; Vanadium - metabolism ; Vanadium - toxicity ; Zinc - metabolism ; Zinc - toxicity</subject><ispartof>Toxicology (Amsterdam), 2003-08, Vol.190 (3), p.171-184</ispartof><rights>2003 Elsevier Science Ireland Ltd</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-1b3eae340ba4638e338268b91fcf43f7cc3ec02d8c44cd1867351ea5db718bea3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0300-483X(03)00162-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15117431$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12927373$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Riley, Mark R.</creatorcontrib><creatorcontrib>Boesewetter, Dianne E.</creatorcontrib><creatorcontrib>Kim, Aana M.</creatorcontrib><creatorcontrib>Sirvent, Francisco P.</creatorcontrib><title>Effects of metals Cu, Fe, Ni, V, and Zn on rat lung epithelial cells</title><title>Toxicology (Amsterdam)</title><addtitle>Toxicology</addtitle><description>Inhalation of combustion-derived particulate matter can have a variety of negative impacts on human health. Metals are known to play a substantial role in these effects, however, the interactions between cellular responses caused by multiple metals is not well understood. The impact of metals (Zn, Cu, Ni, V, and Fe) individually and in combination on a rat lung epithelial cell line (RLE-6TN) was evaluated. Quantifications involved measurement of inhibition of cell culture metabolism (mitochondrial succinate dehydrogenase activity), cell death, mechanisms of cell death, and cytokine secretion. The ranking of metal toxicity based on TC
50 values is V>Zn>Cu>Ni>Fe. Interactions were observed for exposures containing multiple metals: Zn+V, Zn+Cu, Zn+Fe, and Zn+Ni. Zn appears to diminish the negative impact of V and Cu; has an additive effect with Ni, and has no substantial effect on Fe toxicity.</description><subject>Air Pollutants - toxicity</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell death</subject><subject>Cell Death - drug effects</subject><subject>Cells, Cultured</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Copper - metabolism</subject><subject>Copper - toxicity</subject><subject>Epithelial cell</subject><subject>Epithelial Cells - cytology</subject><subject>Epithelial Cells - drug effects</subject><subject>Epithelial Cells - metabolism</subject><subject>Formazans - metabolism</subject><subject>Interleukin-6 - metabolism</subject><subject>Iron - metabolism</subject><subject>Iron - toxicity</subject><subject>Lung - cytology</subject><subject>Lung - drug effects</subject><subject>Lung - metabolism</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>Metals, Heavy - toxicity</subject><subject>Microscopy, Fluorescence</subject><subject>Nickel - metabolism</subject><subject>Nickel - toxicity</subject><subject>Particulate matter</subject><subject>Rats</subject><subject>Succinate Dehydrogenase - metabolism</subject><subject>Tetrazolium Salts - metabolism</subject><subject>Toxicology</subject><subject>Vanadium - metabolism</subject><subject>Vanadium - toxicity</subject><subject>Zinc - metabolism</subject><subject>Zinc - toxicity</subject><issn>0300-483X</issn><issn>1879-3185</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1L5EAQhhtx0dH1Jyh9UVaYaFeqk_ScZBkdVxD34Afipel0qrUlk4zdycL-ezPOoEdPBcXzVr08jO2DOAEB-emtQCESqfDxl8BjMazSRG2wEahikiCobJONPpFtthPjqxAiRZlvsW1IJ2mBBY7Y-YVzZLvIW8fn1Jk68mk_5jMa8xs_5g9jbpqKPzW8bXgwHa_75pnTwncvVHtTc0t1HX-yH25I0t567rL72cXd9E9y_ffyavr7OrFSqS6BEskQSlEamaMiRJXmqpyAs06iK6xFsiKtlJXSVqDyAjMgk1VlAaokg7vsaHV3Edq3nmKn5z4uG5iG2j5qUArSVKgBzFagDW2MgZxeBD834b8GoZf69Ic-vXSjBeoPfXqZO1g_6Ms5VV-pta8BOFwDJlpTu2Aa6-MXlwEUEmHgzlYcDTr-eQo6Wk-NpcqHQbeuWv9NlXdMBonS</recordid><startdate>20030828</startdate><enddate>20030828</enddate><creator>Riley, Mark R.</creator><creator>Boesewetter, Dianne E.</creator><creator>Kim, Aana M.</creator><creator>Sirvent, Francisco P.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20030828</creationdate><title>Effects of metals Cu, Fe, Ni, V, and Zn on rat lung epithelial cells</title><author>Riley, Mark R. ; Boesewetter, Dianne E. ; Kim, Aana M. ; Sirvent, Francisco P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-1b3eae340ba4638e338268b91fcf43f7cc3ec02d8c44cd1867351ea5db718bea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Air Pollutants - toxicity</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell death</topic><topic>Cell Death - drug effects</topic><topic>Cells, Cultured</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Copper - metabolism</topic><topic>Copper - toxicity</topic><topic>Epithelial cell</topic><topic>Epithelial Cells - cytology</topic><topic>Epithelial Cells - drug effects</topic><topic>Epithelial Cells - metabolism</topic><topic>Formazans - metabolism</topic><topic>Interleukin-6 - metabolism</topic><topic>Iron - metabolism</topic><topic>Iron - toxicity</topic><topic>Lung - cytology</topic><topic>Lung - drug effects</topic><topic>Lung - metabolism</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>Metals, Heavy - toxicity</topic><topic>Microscopy, Fluorescence</topic><topic>Nickel - metabolism</topic><topic>Nickel - toxicity</topic><topic>Particulate matter</topic><topic>Rats</topic><topic>Succinate Dehydrogenase - metabolism</topic><topic>Tetrazolium Salts - metabolism</topic><topic>Toxicology</topic><topic>Vanadium - metabolism</topic><topic>Vanadium - toxicity</topic><topic>Zinc - metabolism</topic><topic>Zinc - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Riley, Mark R.</creatorcontrib><creatorcontrib>Boesewetter, Dianne E.</creatorcontrib><creatorcontrib>Kim, Aana M.</creatorcontrib><creatorcontrib>Sirvent, Francisco P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicology (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Riley, Mark R.</au><au>Boesewetter, Dianne E.</au><au>Kim, Aana M.</au><au>Sirvent, Francisco P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of metals Cu, Fe, Ni, V, and Zn on rat lung epithelial cells</atitle><jtitle>Toxicology (Amsterdam)</jtitle><addtitle>Toxicology</addtitle><date>2003-08-28</date><risdate>2003</risdate><volume>190</volume><issue>3</issue><spage>171</spage><epage>184</epage><pages>171-184</pages><issn>0300-483X</issn><eissn>1879-3185</eissn><coden>TXICDD</coden><abstract>Inhalation of combustion-derived particulate matter can have a variety of negative impacts on human health. Metals are known to play a substantial role in these effects, however, the interactions between cellular responses caused by multiple metals is not well understood. The impact of metals (Zn, Cu, Ni, V, and Fe) individually and in combination on a rat lung epithelial cell line (RLE-6TN) was evaluated. Quantifications involved measurement of inhibition of cell culture metabolism (mitochondrial succinate dehydrogenase activity), cell death, mechanisms of cell death, and cytokine secretion. The ranking of metal toxicity based on TC
50 values is V>Zn>Cu>Ni>Fe. Interactions were observed for exposures containing multiple metals: Zn+V, Zn+Cu, Zn+Fe, and Zn+Ni. Zn appears to diminish the negative impact of V and Cu; has an additive effect with Ni, and has no substantial effect on Fe toxicity.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>12927373</pmid><doi>10.1016/S0300-483X(03)00162-8</doi><tpages>14</tpages></addata></record> |
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| subjects | Air Pollutants - toxicity Animals Biological and medical sciences Cell death Cell Death - drug effects Cells, Cultured Chemical and industrial products toxicology. Toxic occupational diseases Copper - metabolism Copper - toxicity Epithelial cell Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - metabolism Formazans - metabolism Interleukin-6 - metabolism Iron - metabolism Iron - toxicity Lung - cytology Lung - drug effects Lung - metabolism Medical sciences Metals and various inorganic compounds Metals, Heavy - toxicity Microscopy, Fluorescence Nickel - metabolism Nickel - toxicity Particulate matter Rats Succinate Dehydrogenase - metabolism Tetrazolium Salts - metabolism Toxicology Vanadium - metabolism Vanadium - toxicity Zinc - metabolism Zinc - toxicity |
| title | Effects of metals Cu, Fe, Ni, V, and Zn on rat lung epithelial cells |
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