Postmenopausal Hormone Therapy and Risk of Breast Cancer by Histologic Type (United States)
Objective: Postmenopausal hormone use and risk of breast cancer by histopathology was examined in a large multicentered population-based case-control study. Methods: Women younger than 75 years newly diagnosed with invasive breast cancer between 1988 and 1991 were identified from statewide tumour re...
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| Veröffentlicht in: | Cancer causes & control 2003-04, Vol.14 (3), p.225-233 |
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| creator | Newcomer, Laura M. Newcomb, Polly A. Potter, John D. Yasui, Yutaka Trentham-Dietz, Amy Storer, Barry E. Longnecker, Matthew P. Baron, John A. Daling, Janet R. |
| description | Objective: Postmenopausal hormone use and risk of breast cancer by histopathology was examined in a large multicentered population-based case-control study. Methods: Women younger than 75 years newly diagnosed with invasive breast cancer between 1988 and 1991 were identified from statewide tumour registries in Wisconsin, Massachusetts, New Hampshire, and Maine. Only postmenopausal women were included in this analysis. Breast cancer cases (lobular (n = 219), ductal, NOS (n = 2172), and specific ductal subtypes (n = 242)) were compared with randomly selected population controls (n = 3179) using adjusted multi-variable polytomous logistic regression to estimate odds ratios (OR) and 95% confidence intervals (95%CI) for each histology. Results: Lobular carcinoma was associated with recent (within 2 years) estrogen therapy (OR:1.8, 95%CI: 1.0-3.4) and recent use of combined estrogen-plus-progestin therapy (OR:3.6, 95%CI: 1.8-7.6). Risk of ductal carcinoma was not associated with recent use of either estrogen alone (OR: 0.9, 95%CI: 0.7-1.2) or combined therapy (OR:0.9, 95%CI: 0.6-1.3). No associations were found with ductal subtypes. Conclusions: The association between postmenopausal hormone use and risk of breast cancer may depend on histopathology. Of particular interest is the association between combined hormone therapy and increased risk of lobular carcinoma. This lesion is increasingly common but, nonetheless, comprises fewer than 10% of invasive breast cancers. |
| doi_str_mv | 10.1023/A:1023634907723 |
| format | Article |
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Methods: Women younger than 75 years newly diagnosed with invasive breast cancer between 1988 and 1991 were identified from statewide tumour registries in Wisconsin, Massachusetts, New Hampshire, and Maine. Only postmenopausal women were included in this analysis. Breast cancer cases (lobular (n = 219), ductal, NOS (n = 2172), and specific ductal subtypes (n = 242)) were compared with randomly selected population controls (n = 3179) using adjusted multi-variable polytomous logistic regression to estimate odds ratios (OR) and 95% confidence intervals (95%CI) for each histology. Results: Lobular carcinoma was associated with recent (within 2 years) estrogen therapy (OR:1.8, 95%CI: 1.0-3.4) and recent use of combined estrogen-plus-progestin therapy (OR:3.6, 95%CI: 1.8-7.6). Risk of ductal carcinoma was not associated with recent use of either estrogen alone (OR: 0.9, 95%CI: 0.7-1.2) or combined therapy (OR:0.9, 95%CI: 0.6-1.3). No associations were found with ductal subtypes. Conclusions: The association between postmenopausal hormone use and risk of breast cancer may depend on histopathology. Of particular interest is the association between combined hormone therapy and increased risk of lobular carcinoma. This lesion is increasingly common but, nonetheless, comprises fewer than 10% of invasive breast cancers.</description><identifier>ISSN: 0957-5243</identifier><identifier>EISSN: 1573-7225</identifier><identifier>DOI: 10.1023/A:1023634907723</identifier><identifier>PMID: 12814201</identifier><identifier>CODEN: CCCNEN</identifier><language>eng</language><publisher>Netherlands: Kluwer Academic Publishers</publisher><subject>Age ; Aged ; Breast cancer ; Breast ductal carcinoma ; Breast Neoplasms - epidemiology ; Breast Neoplasms - etiology ; Breast Neoplasms - pathology ; Carcinoma, Intraductal, Noninfiltrating - epidemiology ; Carcinoma, Intraductal, Noninfiltrating - etiology ; Carcinoma, Intraductal, Noninfiltrating - pathology ; Carcinoma, Lobular - epidemiology ; Carcinoma, Lobular - etiology ; Carcinoma, Lobular - pathology ; Case-Control Studies ; Ductal carcinoma ; Estrogens ; Female ; Histology ; Histopathology ; Hormone replacement therapy ; Hormone Replacement Therapy - adverse effects ; Hormone therapy ; Hormones ; Humans ; Lobular carcinoma ; Menopause ; Middle Aged ; Oophorectomy ; Population ; Postmenopause ; Research Papers ; Risk Assessment ; United States - epidemiology ; Womens health</subject><ispartof>Cancer causes & control, 2003-04, Vol.14 (3), p.225-233</ispartof><rights>Copyright 2003 Kluwer Academic Publishers</rights><rights>Copyright Kluwer Academic Publishers Apr 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-17f8705f505d614b60ee47ecc481df7da2509f96bc7c4ca26365e407b8f4baa43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3553971$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3553971$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,778,782,801,27911,27912,58004,58237</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12814201$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Newcomer, Laura M.</creatorcontrib><creatorcontrib>Newcomb, Polly A.</creatorcontrib><creatorcontrib>Potter, John D.</creatorcontrib><creatorcontrib>Yasui, Yutaka</creatorcontrib><creatorcontrib>Trentham-Dietz, Amy</creatorcontrib><creatorcontrib>Storer, Barry E.</creatorcontrib><creatorcontrib>Longnecker, Matthew P.</creatorcontrib><creatorcontrib>Baron, John A.</creatorcontrib><creatorcontrib>Daling, Janet R.</creatorcontrib><title>Postmenopausal Hormone Therapy and Risk of Breast Cancer by Histologic Type (United States)</title><title>Cancer causes & control</title><addtitle>Cancer Causes Control</addtitle><description>Objective: Postmenopausal hormone use and risk of breast cancer by histopathology was examined in a large multicentered population-based case-control study. Methods: Women younger than 75 years newly diagnosed with invasive breast cancer between 1988 and 1991 were identified from statewide tumour registries in Wisconsin, Massachusetts, New Hampshire, and Maine. Only postmenopausal women were included in this analysis. Breast cancer cases (lobular (n = 219), ductal, NOS (n = 2172), and specific ductal subtypes (n = 242)) were compared with randomly selected population controls (n = 3179) using adjusted multi-variable polytomous logistic regression to estimate odds ratios (OR) and 95% confidence intervals (95%CI) for each histology. Results: Lobular carcinoma was associated with recent (within 2 years) estrogen therapy (OR:1.8, 95%CI: 1.0-3.4) and recent use of combined estrogen-plus-progestin therapy (OR:3.6, 95%CI: 1.8-7.6). Risk of ductal carcinoma was not associated with recent use of either estrogen alone (OR: 0.9, 95%CI: 0.7-1.2) or combined therapy (OR:0.9, 95%CI: 0.6-1.3). No associations were found with ductal subtypes. Conclusions: The association between postmenopausal hormone use and risk of breast cancer may depend on histopathology. Of particular interest is the association between combined hormone therapy and increased risk of lobular carcinoma. This lesion is increasingly common but, nonetheless, comprises fewer than 10% of invasive breast cancers.</description><subject>Age</subject><subject>Aged</subject><subject>Breast cancer</subject><subject>Breast ductal carcinoma</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Breast Neoplasms - etiology</subject><subject>Breast Neoplasms - pathology</subject><subject>Carcinoma, Intraductal, Noninfiltrating - epidemiology</subject><subject>Carcinoma, Intraductal, Noninfiltrating - etiology</subject><subject>Carcinoma, Intraductal, Noninfiltrating - pathology</subject><subject>Carcinoma, Lobular - epidemiology</subject><subject>Carcinoma, Lobular - etiology</subject><subject>Carcinoma, Lobular - pathology</subject><subject>Case-Control Studies</subject><subject>Ductal carcinoma</subject><subject>Estrogens</subject><subject>Female</subject><subject>Histology</subject><subject>Histopathology</subject><subject>Hormone replacement therapy</subject><subject>Hormone Replacement Therapy - adverse effects</subject><subject>Hormone therapy</subject><subject>Hormones</subject><subject>Humans</subject><subject>Lobular carcinoma</subject><subject>Menopause</subject><subject>Middle Aged</subject><subject>Oophorectomy</subject><subject>Population</subject><subject>Postmenopause</subject><subject>Research Papers</subject><subject>Risk Assessment</subject><subject>United States - epidemiology</subject><subject>Womens health</subject><issn>0957-5243</issn><issn>1573-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpd0D1PwzAQBmALgWgpzCwIWQwIhoA_44StVECRKoGgnRgix7lAShIHOxny7wlqYWB6h3v06u4QOqbkihLGr6c3PxFyEROlGN9BYyoVDxRjcheNSSxVIJngI3Tg_ZoQIkNG9tGIsogKRugYvT1b31ZQ20Z3Xpd4bl1la8DLD3C66bGuM_xS-E9sc3zrQPsWz3RtwOG0x_PCt7a074XBy74BfLGqixYy_NrqFvzlIdrLdenhaJsTtLq_W87mweLp4XE2XQSGc9YGVOWRIjKXRGYhFWlIAIQCY0REs1xlmkkS53GYGmWE0SzkoQRBVBrlItVa8Ak63_Q2zn514NukKryBstQ12M4nNIooVSEd4Nk_uLadq4fdEkY5JULyaECnW9SlFWRJ44pKuz75_dkATjZgPVzv_uZcSh4ryr8BuIt2DA</recordid><startdate>20030401</startdate><enddate>20030401</enddate><creator>Newcomer, Laura M.</creator><creator>Newcomb, Polly A.</creator><creator>Potter, John D.</creator><creator>Yasui, Yutaka</creator><creator>Trentham-Dietz, Amy</creator><creator>Storer, Barry E.</creator><creator>Longnecker, Matthew P.</creator><creator>Baron, John A.</creator><creator>Daling, Janet R.</creator><general>Kluwer Academic Publishers</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>20030401</creationdate><title>Postmenopausal Hormone Therapy and Risk of Breast Cancer by Histologic Type (United States)</title><author>Newcomer, Laura M. ; Newcomb, Polly A. ; Potter, John D. ; Yasui, Yutaka ; Trentham-Dietz, Amy ; Storer, Barry E. ; Longnecker, Matthew P. ; Baron, John A. ; Daling, Janet R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-17f8705f505d614b60ee47ecc481df7da2509f96bc7c4ca26365e407b8f4baa43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Age</topic><topic>Aged</topic><topic>Breast cancer</topic><topic>Breast ductal carcinoma</topic><topic>Breast Neoplasms - epidemiology</topic><topic>Breast Neoplasms - etiology</topic><topic>Breast Neoplasms - pathology</topic><topic>Carcinoma, Intraductal, Noninfiltrating - epidemiology</topic><topic>Carcinoma, Intraductal, Noninfiltrating - etiology</topic><topic>Carcinoma, Intraductal, Noninfiltrating - pathology</topic><topic>Carcinoma, Lobular - epidemiology</topic><topic>Carcinoma, Lobular - etiology</topic><topic>Carcinoma, Lobular - pathology</topic><topic>Case-Control Studies</topic><topic>Ductal carcinoma</topic><topic>Estrogens</topic><topic>Female</topic><topic>Histology</topic><topic>Histopathology</topic><topic>Hormone replacement therapy</topic><topic>Hormone Replacement Therapy - adverse effects</topic><topic>Hormone therapy</topic><topic>Hormones</topic><topic>Humans</topic><topic>Lobular carcinoma</topic><topic>Menopause</topic><topic>Middle Aged</topic><topic>Oophorectomy</topic><topic>Population</topic><topic>Postmenopause</topic><topic>Research Papers</topic><topic>Risk Assessment</topic><topic>United States - epidemiology</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Newcomer, Laura M.</creatorcontrib><creatorcontrib>Newcomb, Polly A.</creatorcontrib><creatorcontrib>Potter, John D.</creatorcontrib><creatorcontrib>Yasui, Yutaka</creatorcontrib><creatorcontrib>Trentham-Dietz, Amy</creatorcontrib><creatorcontrib>Storer, Barry E.</creatorcontrib><creatorcontrib>Longnecker, Matthew P.</creatorcontrib><creatorcontrib>Baron, John A.</creatorcontrib><creatorcontrib>Daling, Janet R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Cancer causes & control</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Newcomer, Laura M.</au><au>Newcomb, Polly A.</au><au>Potter, John D.</au><au>Yasui, Yutaka</au><au>Trentham-Dietz, Amy</au><au>Storer, Barry E.</au><au>Longnecker, Matthew P.</au><au>Baron, John A.</au><au>Daling, Janet R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postmenopausal Hormone Therapy and Risk of Breast Cancer by Histologic Type (United States)</atitle><jtitle>Cancer causes & control</jtitle><addtitle>Cancer Causes Control</addtitle><date>2003-04-01</date><risdate>2003</risdate><volume>14</volume><issue>3</issue><spage>225</spage><epage>233</epage><pages>225-233</pages><issn>0957-5243</issn><eissn>1573-7225</eissn><coden>CCCNEN</coden><abstract>Objective: Postmenopausal hormone use and risk of breast cancer by histopathology was examined in a large multicentered population-based case-control study. Methods: Women younger than 75 years newly diagnosed with invasive breast cancer between 1988 and 1991 were identified from statewide tumour registries in Wisconsin, Massachusetts, New Hampshire, and Maine. Only postmenopausal women were included in this analysis. Breast cancer cases (lobular (n = 219), ductal, NOS (n = 2172), and specific ductal subtypes (n = 242)) were compared with randomly selected population controls (n = 3179) using adjusted multi-variable polytomous logistic regression to estimate odds ratios (OR) and 95% confidence intervals (95%CI) for each histology. Results: Lobular carcinoma was associated with recent (within 2 years) estrogen therapy (OR:1.8, 95%CI: 1.0-3.4) and recent use of combined estrogen-plus-progestin therapy (OR:3.6, 95%CI: 1.8-7.6). Risk of ductal carcinoma was not associated with recent use of either estrogen alone (OR: 0.9, 95%CI: 0.7-1.2) or combined therapy (OR:0.9, 95%CI: 0.6-1.3). No associations were found with ductal subtypes. Conclusions: The association between postmenopausal hormone use and risk of breast cancer may depend on histopathology. Of particular interest is the association between combined hormone therapy and increased risk of lobular carcinoma. This lesion is increasingly common but, nonetheless, comprises fewer than 10% of invasive breast cancers.</abstract><cop>Netherlands</cop><pub>Kluwer Academic Publishers</pub><pmid>12814201</pmid><doi>10.1023/A:1023634907723</doi><tpages>9</tpages></addata></record> |
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| subjects | Age Aged Breast cancer Breast ductal carcinoma Breast Neoplasms - epidemiology Breast Neoplasms - etiology Breast Neoplasms - pathology Carcinoma, Intraductal, Noninfiltrating - epidemiology Carcinoma, Intraductal, Noninfiltrating - etiology Carcinoma, Intraductal, Noninfiltrating - pathology Carcinoma, Lobular - epidemiology Carcinoma, Lobular - etiology Carcinoma, Lobular - pathology Case-Control Studies Ductal carcinoma Estrogens Female Histology Histopathology Hormone replacement therapy Hormone Replacement Therapy - adverse effects Hormone therapy Hormones Humans Lobular carcinoma Menopause Middle Aged Oophorectomy Population Postmenopause Research Papers Risk Assessment United States - epidemiology Womens health |
| title | Postmenopausal Hormone Therapy and Risk of Breast Cancer by Histologic Type (United States) |
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