Association of NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism with esophageal squamous cell carcinoma in a German Caucasian and a northern Chinese population

NAD(P)H: quinone oxidoreductase 1 (NQO1) is an antioxidant enzyme, important in the detoxification of environmental carcinogens. A single base substitution (C → T) polymorphism at nucleotide 609 (null-allele) of NQO1 gene impairs stability and function of the NQO1 protein. To investigate the associa...

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Veröffentlicht in:	Carcinogenesis (New York) 2003-05, Vol.24 (5), p.905-909
Hauptverfasser:	Zhang, Jianhui, Schulz, Wolfgang A., Li, Yan, Wang, Rui, Zotz, Rainer, Wen, Denggui, Siegel, David, Ross, David, Gabbert, Helmut E., Sarbia, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Asian Continental Ancestry Group - genetics Biological and medical sciences Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - ethnology Carcinoma, Squamous Cell - genetics Case-Control Studies China - epidemiology confidence interval DNA - genetics DNA - metabolism DNA Primers - chemistry ESCC Esophageal Neoplasms - enzymology Esophageal Neoplasms - ethnology Esophageal Neoplasms - genetics esophageal squamous cell carcinoma Esophagus European Continental Ancestry Group - genetics Family Female Gastroenterology. Liver. Pancreas. Abdomen Gene Frequency Genetic Predisposition to Disease Genotype Germany - epidemiology Humans Immunoenzyme Techniques Male Medical sciences Middle Aged NAD(P)H Dehydrogenase (Quinone) - genetics NAD(P)H Dehydrogenase (Quinone) - metabolism NAD(P)H: quinone oxidoreductase 1 NQO1 odds ratio PCR Polymerase Chain Reaction Polymorphism, Single Nucleotide - genetics Polymorphism, Single-Stranded Conformational restriction fragment length polymorphism analysis RFLP Risk Factors Tumors UGIC upper gastrointestinal cancer
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