p21/CDKN1A Mediates Negative Regulation of Transcription by p53

The tumor suppressor p53 regulates transcription positively and negatively, depending on the target gene. Whereas p53 induces transcription through direct interaction with promoter DNA, the mechanism of p53-mediated transcriptional repression is less well understood. Early reports described the alle...

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Veröffentlicht in:	The Journal of biological chemistry 2003-08, Vol.278 (35), p.32507-32516
Hauptverfasser:	Löhr, Kristina, Möritz, Constanze, Contente, Ana, Dobbelstein, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Amino Acid Sequence Apoptosis Base Sequence Binding Sites Cell Line Cyclin-Dependent Kinase Inhibitor p21 Cyclins - genetics Cyclins - metabolism Cyclins - physiology DNA-Binding Proteins - metabolism Gene Deletion Gene Expression Regulation Genes, p53 Genes, Tumor Suppressor Genetic Vectors Humans Immunoblotting Inhibitor of Apoptosis Proteins Microtubule Proteins Microtubule-Associated Proteins - metabolism Mitochondria - metabolism Molecular Sequence Data Mutation Neoplasm Proteins Nuclear Proteins - metabolism Phosphoproteins - metabolism Plasmids - metabolism Protein Structure, Tertiary Proto-Oncogene Proteins c-myc - metabolism Reverse Transcriptase Polymerase Chain Reaction Stathmin Survivin Time Factors Transcription, Genetic Transcriptional Activation Transfection Tumor Protein p73 Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Proteins
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