Role of hMLH1 promoter hypermethylation in drug resistance to 5‐fluorouracil in colorectal cancer cell lines

Loss of DNA mismatch repair (MMR) occurs in 10–15% of sporadic colorectal cancer, is usually caused by hMLH1 hypermethylation, and has been shown to confer resistance to various chemotherapeutic reagents, including 5‐fluorouracil (5‐FU). We tested the hypothesis that demethylation of the hMLH1 promo...

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Veröffentlicht in:	International journal of cancer 2003-08, Vol.106 (1), p.66-73
Hauptverfasser:	Arnold, Christian N., Goel, Ajay, Boland, C. Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	5‐FU resistance Adaptor Proteins, Signal Transducing Antimetabolites, Antineoplastic - pharmacology Antineoplastic agents Azacitidine - analogs & derivatives Azacitidine - pharmacology Base Pair Mismatch Biological and medical sciences Blotting, Western Carrier Proteins Cloning, Molecular Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Cyclin-Dependent Kinase Inhibitor p16 - genetics DNA Methylation DNA Repair Drug Resistance, Neoplasm Enzyme Inhibitors - pharmacology Fluorouracil - pharmacology General aspects Humans Immunoblotting Kruppel-Like Transcription Factors Medical sciences microsatellite instability Microsatellite Repeats mismatch repair MutL Protein Homolog 1 Neoplasm Proteins - genetics Nuclear Proteins Pharmacology. Drug treatments Promoter Regions, Genetic Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Time Factors Transcription Factors - genetics Transcriptional Activation Tumor Cells, Cultured
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