CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members

Familial cylindromatosis is an autosomal dominant predisposition to tumours of skin appendages called cylindromas. Familial cylindromatosis is caused by mutations in a gene encoding the CYLD protein of previously unknown function. Here we show that CYLD is a deubiquitinating enzyme that negatively r...

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Veröffentlicht in:	Nature 2003-08, Vol.424 (6950), p.793-796
Hauptverfasser:	Mosialos, George, Trompouki, Eirini, Hatzivassiliou, Eudoxia, Tsichritzis, Theodore, Farmer, Hannah, Ashworth, Alan
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Dermatology Medical sciences Tumors of the skin and soft tissue. Premalignant lesions
Online-Zugang:	Volltext
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