High-performance liquid chromatographic determination of cocaine and benzoylecgonine by direct injection of human blood plasma sample into an alkyl-diol-silica (ADS) precolumn

A column-switching high-performance liquid chromatographic method with UV detection for the determination of cocaine (COC) and benzoylecgonine (BZE) in human blood plasma samples is described. The method uses an alkyl-diol-silica ADS-C18 extraction precolumn. A 50- micro L plasma sample was introduc...

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Veröffentlicht in:	Analytical and bioanalytical chemistry 2003-02, Vol.375 (4), p.534-538
Hauptverfasser:	Brunetto, Rosario, Gutiérrez, Lubin, Delgado, Yelitza, Gallignani, Máximo, Burguera, José Luis, Burguera, Marcela
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatography, High Pressure Liquid - instrumentation Chromatography, High Pressure Liquid - methods Cocaine - analogs & derivatives Cocaine - blood Equipment Design Humans Hydrogen-Ion Concentration Reference Standards Silicon Dioxide Solvents Substance-Related Disorders - blood Substance-Related Disorders - diagnosis
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