Transforming growth factor- beta 1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF- Kappa B, JNK, and Ras signaling pathways

Transforming growth factor (TGF)- beta 1 acts as a potent growth inhibitor of prostate epithelial cells, and aberrant function of its receptor type I and II correlates with tumor aggressiveness. However, intracellular and serum TGF- beta 1 levels are elevated in prostate cancer patients and further...

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Veröffentlicht in:	Oncogene 2003-07, Vol.22 (28), p.4314-4332
Hauptverfasser:	Park, J-I, Lee, M-G, Cho, K, Park, B-J, Chae, K-S, Byun, D-S, Ryu, B-K, Park, Y-K, Chi, S-G
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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