Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement

Polycomb group protein Ezh2 is an essential epigenetic regulator of embryonic development in mice, but its role in the adult organism is unknown. High expression of Ezh2 in developing murine lymphocytes suggests Ezh2 involvement in lymphopoiesis. Using Cre-mediated conditional mutagenesis, we demons...

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Veröffentlicht in:	Nature immunology 2003-02, Vol.4 (2), p.124-131
Hauptverfasser:	Su, I-hsin, Basavaraj, Ashwin, Krutchinsky, Andrew N., Hobert, Oliver, Ullrich, Axel, Chait, Brian T., Tarakhovsky, Alexander
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - cytology B-Lymphocytes - immunology B-Lymphocytes - metabolism Biomedicine Cell Differentiation DNA-Binding Proteins - metabolism Embryonic growth stage Gene Expression Regulation, Developmental Gene Rearrangement, B-Lymphocyte, Heavy Chain Histones - metabolism Immunology Infectious Diseases Lymphocytes Methylation Mice Mice, Knockout Mice, Transgenic Milk Proteins Mutagenesis Polycomb-Group Proteins Repressor Proteins - genetics Repressor Proteins - immunology Repressor Proteins - metabolism STAT5 Transcription Factor Trans-Activators - metabolism
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