The Acrodermatitis Enteropathica Gene ZIP4 Encodes a Tissue-specific, Zinc-regulated Zinc Transporter in Mice

The human ZIP4 gene (SLC39A4) is a candidate for the genetic disorder of zinc metabolism acrodermatitis enteropathica. To understand its role in zinc homeostasis, we examined the function and expression of mouse ZIP4. This gene encodes a well conserved eight-transmembrane protein that can specifical...

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Veröffentlicht in:	The Journal of biological chemistry 2003-08, Vol.278 (35), p.33474-33481
Hauptverfasser:	Dufner-Beattie, Jodi, Wang, Fudi, Kuo, Yien-Ming, Gitschier, Jane, Eide, David, Andrews, Glen K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrodermatitis - metabolism Amino Acid Sequence Animals Biological Transport Blotting, Northern Carrier Proteins - metabolism Cation Transport Proteins - chemistry Cation Transport Proteins - metabolism Cation Transport Proteins - physiology Cations Cell Membrane - metabolism Dose-Response Relationship, Drug Female Immunohistochemistry Intestinal Mucosa - metabolism Intestine, Small - embryology Kinetics Male Metals - chemistry Mice Models, Genetic Molecular Sequence Data Peptides - chemistry Plasmids - metabolism Protein Structure, Tertiary Reverse Transcriptase Polymerase Chain Reaction RNA - metabolism RNA, Messenger - metabolism Sequence Homology, Amino Acid Tissue Distribution Transfection Zinc - metabolism
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