Entrapment of Rho ADP-ribosylated by Clostridium botulinum C3 Exoenzyme in the Rho-Guanine Nucleotide Dissociation Inhibitor-1 Complex

RhoA, -B, and -C are ADP-ribosylated by Clostridium botulinum exoenzyme C3 to induce redistribution of the actin filaments in intact cells, a finding that has led to the notion that the ADP-ribosylation blocks coupling of Rho to the downstream effectors. ADP-ribosylation, however, does not alter nuc...

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Veröffentlicht in:	The Journal of biological chemistry 2003-08, Vol.278 (31), p.28523-28527
Hauptverfasser:	Genth, Harald, Gerhard, Ralf, Maeda, Akio, Amano, Mutsuki, Kaibuchi, Kozo, Aktories, Klaus, Just, Ingo
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells ADP Ribose Transferases - metabolism Animals Botulinum Toxins - metabolism Drug Stability Electrophoresis, Polyacrylamide Gel Glutathione Transferase - genetics GTP Phosphohydrolases - metabolism Guanine Nucleotide Dissociation Inhibitors - genetics Guanine Nucleotide Dissociation Inhibitors - metabolism Guanosine 5'-O-(3-Thiotriphosphate) - metabolism Mice Phosphatidylinositol 4,5-Diphosphate - metabolism ras Proteins Recombinant Fusion Proteins Recombinant Proteins rho GTP-Binding Proteins - genetics rho GTP-Binding Proteins - metabolism rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - metabolism rhoB GTP-Binding Protein - genetics rhoB GTP-Binding Protein - metabolism rhoC GTP-Binding Protein
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