Chronic studies evaluating the carcinogenicity of monomethylarsonic acid in rats and mice

Monomethylarsonic acid (MMA) was administered in the diet of male and female Fischer F344 rats and B6C3F1 mice in 2-year feeding studies according to US EPA guidelines. Rats were treated with 50, 400, or 1300 ppm MMA and mice were treated with 10, 50, 200, or 400 ppm MMA based on preliminary short-t...

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Veröffentlicht in:	Toxicology (Amsterdam) 2003-08, Vol.190 (3), p.197-219
Hauptverfasser:	Arnold, Lora L, Eldan, Michal, van Gemert, Marcia, Capen, Charles C, Cohen, Samuel M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arsenic Poisoning - blood Arsenic Poisoning - etiology Arsenic Poisoning - urine Arsenicals - adverse effects Biological and medical sciences Body Weight - drug effects Carcinogenicity Carcinogenicity Tests Chemical and industrial products toxicology. Toxic occupational diseases Chronic toxicity Dose-Response Relationship, Drug Drinking - drug effects Female Herbicides - toxicity Intestine, Large - drug effects Intestine, Large - pathology Large intestine Longitudinal Studies Male Medical sciences Metals and various inorganic compounds Mice Mice, Inbred C3H Mice, Inbred C57BL Monomethylarsonic acid Neoplasms, Experimental - chemically induced Organ Size - drug effects Random Allocation Rats Rats, Inbred F344 Toxicology
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