Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin

Apelin peptides have recently been identified to be the endogenous ligands for the G protein‐coupled receptor APJ. However, little is known about the physiological roles of this ligand‐receptor pairing. In the present study we investigated the pharmacology of several apelin analogues at the human re...

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Veröffentlicht in:	Journal of neurochemistry 2003-03, Vol.84 (5), p.1162-1172
Hauptverfasser:	Medhurst, Andrew D., Jennings, Carol A., Robbins, Melanie J., Davis, Robert P., Ellis, Catherine, Winborn, Kim Y., Lawrie, Kenneth W. M., Hervieu, Guillaume, Riley, Graham, Bolaky, Jane E., Herrity, Nicole C., Murdock, Paul, Darker, John G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipokines Amino Acid Substitution Animals Apelin Apelin Receptors APJ receptor Binding, Competitive - physiology Biological and medical sciences Blotting, Western Brain - metabolism Carrier Proteins - biosynthesis Carrier Proteins - chemistry Carrier Proteins - genetics Carrier Proteins - metabolism Cell Line Cell receptors Cell structures and functions Cyclic AMP - metabolism Fluorometry Fundamental and applied biological sciences. Psychology Humans Immunohistochemistry Intercellular Signaling Peptides and Proteins Ligands Mice Miscellaneous Molecular and cellular biology Mutagenesis, Site-Directed Organ Specificity Protein Binding - physiology Radioligand Assay Rats Receptors, Dopamine D2 - chemistry Receptors, Dopamine D2 - genetics Receptors, Dopamine D2 - metabolism Receptors, G-Protein-Coupled Reverse Transcriptase Polymerase Chain Reaction Spinal Cord - metabolism Structure-Activity Relationship TaqMan
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