Analysis of HLA-E Peptide-Binding Specificity and Contact Residues in Bound Peptide Required for Recognition by CD94/NKG2

The MHC class Ib molecule HLA-E is the primary ligand for CD94/NKG2A-inhibitory receptors expressed on NK cells, and there is also evidence for TCR-mediated recognition of this molecule. HLA-E preferentially assembles with a homologous set of peptides derived from the leader sequence of class Ia mol...

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Veröffentlicht in:	The Journal of immunology (1950) 2003-08, Vol.171 (3), p.1369-1375
Hauptverfasser:	Miller, Joseph D, Weber, Dominique A, Ibegbu, Chris, Pohl, Jan, Altman, John D, Jensen, Peter E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs - genetics Amino Acid Motifs - immunology Amino Acid Substitution - genetics Animals Antigens, CD - metabolism Binding, Competitive - genetics Binding, Competitive - immunology Epitopes - genetics Epitopes - metabolism Escherichia coli - genetics Escherichia coli - immunology Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - metabolism HLA Antigens - genetics HLA Antigens - metabolism HLA-E Antigens Humans Immunoassay Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Lectins, C-Type - antagonists & inhibitors Lectins, C-Type - metabolism Lysine - genetics Lysine - metabolism Macaca mulatta Mice Mice, Inbred C57BL NK Cell Lectin-Like Receptor Subfamily C NK Cell Lectin-Like Receptor Subfamily D Oligopeptides - chemical synthesis Oligopeptides - genetics Oligopeptides - immunology Oligopeptides - metabolism Peptide Library Protein Binding - genetics Protein Binding - immunology Protein Folding Receptors, Immunologic - antagonists & inhibitors Receptors, Immunologic - metabolism Receptors, Natural Killer Cell Recombinant Proteins - chemical synthesis Recombinant Proteins - metabolism
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