The association between polycystic ovary syndrome, obesity, and the serum concentration of adipokines
Purpose This study aimed to investigate the interactive effect of polycystic ovary syndrome (PCOS) status and obesity status on the serum levels of adipokines. Methods In this comparative case–control cross-sectional study, 58 women with PCOS and 104 eumenorrheic non-hirsute women as the control gro...
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| Veröffentlicht in: | Journal of endocrinological investigation 2017-08, Vol.40 (8), p.859-866 |
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| creator | Behboudi-Gandevani, S. Ramezani Tehrani, F. Bidhendi Yarandi, R. Noroozzadeh, M. Hedayati, M. Azizi, F. |
| description | Purpose
This study aimed to investigate the interactive effect of polycystic ovary syndrome (PCOS) status and obesity status on the serum levels of adipokines.
Methods
In this comparative case–control cross-sectional study, 58 women with PCOS and 104 eumenorrheic non-hirsute women as the control group were recruited. They were further divided into two subgroups of overweight/obese and normal weight. The interactive effect of the PCOS status and obesity status on the circulating levels of adipokines was assessed using general linear model with the adjustment of age.
Results
A statistically significant negative interaction was reported between obesity status and PCOS status in the determination of serum adiponectin and resistin concentrations (effect size = −0.14, interaction
P
= 0.001, effect size = −0.15,
P
= 0.016). It indicated that adiponectin and resistin were significantly decreased in overweight/obese patients with PCOS compared with other subgroups. Statistically significant positive interactive effects were found between PCOS status obesity status and leptin (effect size = 0.321, interaction
P
= 0.036), indicating that the overweight/obese women with PCOS had the higher levels of leptin compared with the control group. Also, no interaction was reported between PCOS status and obesity status with regard to the serum levels of other adipokines.
Conclusions
While no sufficient evidence is available with regard to the causal association between adipokines and PCOS, they may contribute to the development of PCOS and regarded as the novel biomarkers of PCOS. |
| doi_str_mv | 10.1007/s40618-017-0650-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1880469685</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1880469685</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-627c82681d365102da8b39a0e78d460eb725476a8604a22d2c5526ce4af3f73b3</originalsourceid><addsrcrecordid>eNp1kc1O3TAQha2qqFDoA3SDLHXTBYGxndi-S4T6g4TUDawtx5m0oTf2xZO05O0xCkUIqSuP5O-cGZ3D2EcBpwLAnFENWtgKhKlAN1Ddv2EHwkiorLL67Yt5n70nugVQRlnzju1Lq5QUBg4YXv9C7olSGPw0pMhbnP4iRr5L2yUsNA2Bpz8-L5yW2OU04glPLdIwLSfcx45PRU-Y55GHFAPGKa8-qee-G3bp9xCRjthe77eEH57eQ3bz9cv1xffq6se3y4vzqyrUEqZKSxOs1FZ0SjcCZOdtqzYe0Niu1oCtkU1ttLcaai9lJ0PTSB2w9r3qjWrVIfu8-u5yupuRJjcOFHC79RHTTE5YC7XeaNsU9NMr9DbNOZbrnNiIjdYlK1EosVIhJ6KMvdvlYSxxOAHusQO3duBKB-6xA3dfNMdPznM7Yves-Bd6AeQKUPmKPzG_WP1f1wdjiJJA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1919663731</pqid></control><display><type>article</type><title>The association between polycystic ovary syndrome, obesity, and the serum concentration of adipokines</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Behboudi-Gandevani, S. ; Ramezani Tehrani, F. ; Bidhendi Yarandi, R. ; Noroozzadeh, M. ; Hedayati, M. ; Azizi, F.</creator><creatorcontrib>Behboudi-Gandevani, S. ; Ramezani Tehrani, F. ; Bidhendi Yarandi, R. ; Noroozzadeh, M. ; Hedayati, M. ; Azizi, F.</creatorcontrib><description>Purpose
This study aimed to investigate the interactive effect of polycystic ovary syndrome (PCOS) status and obesity status on the serum levels of adipokines.
Methods
In this comparative case–control cross-sectional study, 58 women with PCOS and 104 eumenorrheic non-hirsute women as the control group were recruited. They were further divided into two subgroups of overweight/obese and normal weight. The interactive effect of the PCOS status and obesity status on the circulating levels of adipokines was assessed using general linear model with the adjustment of age.
Results
A statistically significant negative interaction was reported between obesity status and PCOS status in the determination of serum adiponectin and resistin concentrations (effect size = −0.14, interaction
P
= 0.001, effect size = −0.15,
P
= 0.016). It indicated that adiponectin and resistin were significantly decreased in overweight/obese patients with PCOS compared with other subgroups. Statistically significant positive interactive effects were found between PCOS status obesity status and leptin (effect size = 0.321, interaction
P
= 0.036), indicating that the overweight/obese women with PCOS had the higher levels of leptin compared with the control group. Also, no interaction was reported between PCOS status and obesity status with regard to the serum levels of other adipokines.
Conclusions
While no sufficient evidence is available with regard to the causal association between adipokines and PCOS, they may contribute to the development of PCOS and regarded as the novel biomarkers of PCOS.</description><identifier>ISSN: 1720-8386</identifier><identifier>ISSN: 0391-4097</identifier><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.1007/s40618-017-0650-x</identifier><identifier>PMID: 28332170</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adipokines - blood ; Adiponectin ; Adult ; Biomarkers - blood ; Body Mass Index ; Body weight ; Case-Control Studies ; Cross-Sectional Studies ; Endocrinology ; Female ; Humans ; Insulin Resistance ; Leptin ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Obesity ; Obesity - complications ; Original Article ; Overweight ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - blood ; Polycystic Ovary Syndrome - etiology ; Polycystic Ovary Syndrome - pathology ; Serum levels ; Statistical analysis ; Young Adult</subject><ispartof>Journal of endocrinological investigation, 2017-08, Vol.40 (8), p.859-866</ispartof><rights>Italian Society of Endocrinology (SIE) 2017</rights><rights>Copyright Springer Science & Business Media 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-627c82681d365102da8b39a0e78d460eb725476a8604a22d2c5526ce4af3f73b3</citedby><cites>FETCH-LOGICAL-c420t-627c82681d365102da8b39a0e78d460eb725476a8604a22d2c5526ce4af3f73b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40618-017-0650-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40618-017-0650-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28332170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Behboudi-Gandevani, S.</creatorcontrib><creatorcontrib>Ramezani Tehrani, F.</creatorcontrib><creatorcontrib>Bidhendi Yarandi, R.</creatorcontrib><creatorcontrib>Noroozzadeh, M.</creatorcontrib><creatorcontrib>Hedayati, M.</creatorcontrib><creatorcontrib>Azizi, F.</creatorcontrib><title>The association between polycystic ovary syndrome, obesity, and the serum concentration of adipokines</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><addtitle>J Endocrinol Invest</addtitle><description>Purpose
This study aimed to investigate the interactive effect of polycystic ovary syndrome (PCOS) status and obesity status on the serum levels of adipokines.
Methods
In this comparative case–control cross-sectional study, 58 women with PCOS and 104 eumenorrheic non-hirsute women as the control group were recruited. They were further divided into two subgroups of overweight/obese and normal weight. The interactive effect of the PCOS status and obesity status on the circulating levels of adipokines was assessed using general linear model with the adjustment of age.
Results
A statistically significant negative interaction was reported between obesity status and PCOS status in the determination of serum adiponectin and resistin concentrations (effect size = −0.14, interaction
P
= 0.001, effect size = −0.15,
P
= 0.016). It indicated that adiponectin and resistin were significantly decreased in overweight/obese patients with PCOS compared with other subgroups. Statistically significant positive interactive effects were found between PCOS status obesity status and leptin (effect size = 0.321, interaction
P
= 0.036), indicating that the overweight/obese women with PCOS had the higher levels of leptin compared with the control group. Also, no interaction was reported between PCOS status and obesity status with regard to the serum levels of other adipokines.
Conclusions
While no sufficient evidence is available with regard to the causal association between adipokines and PCOS, they may contribute to the development of PCOS and regarded as the novel biomarkers of PCOS.</description><subject>Adipokines - blood</subject><subject>Adiponectin</subject><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Body Mass Index</subject><subject>Body weight</subject><subject>Case-Control Studies</subject><subject>Cross-Sectional Studies</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Humans</subject><subject>Insulin Resistance</subject><subject>Leptin</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Original Article</subject><subject>Overweight</subject><subject>Polycystic ovary syndrome</subject><subject>Polycystic Ovary Syndrome - blood</subject><subject>Polycystic Ovary Syndrome - etiology</subject><subject>Polycystic Ovary Syndrome - pathology</subject><subject>Serum levels</subject><subject>Statistical analysis</subject><subject>Young Adult</subject><issn>1720-8386</issn><issn>0391-4097</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1O3TAQha2qqFDoA3SDLHXTBYGxndi-S4T6g4TUDawtx5m0oTf2xZO05O0xCkUIqSuP5O-cGZ3D2EcBpwLAnFENWtgKhKlAN1Ddv2EHwkiorLL67Yt5n70nugVQRlnzju1Lq5QUBg4YXv9C7olSGPw0pMhbnP4iRr5L2yUsNA2Bpz8-L5yW2OU04glPLdIwLSfcx45PRU-Y55GHFAPGKa8-qee-G3bp9xCRjthe77eEH57eQ3bz9cv1xffq6se3y4vzqyrUEqZKSxOs1FZ0SjcCZOdtqzYe0Niu1oCtkU1ttLcaai9lJ0PTSB2w9r3qjWrVIfu8-u5yupuRJjcOFHC79RHTTE5YC7XeaNsU9NMr9DbNOZbrnNiIjdYlK1EosVIhJ6KMvdvlYSxxOAHusQO3duBKB-6xA3dfNMdPznM7Yves-Bd6AeQKUPmKPzG_WP1f1wdjiJJA</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Behboudi-Gandevani, S.</creator><creator>Ramezani Tehrani, F.</creator><creator>Bidhendi Yarandi, R.</creator><creator>Noroozzadeh, M.</creator><creator>Hedayati, M.</creator><creator>Azizi, F.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170801</creationdate><title>The association between polycystic ovary syndrome, obesity, and the serum concentration of adipokines</title><author>Behboudi-Gandevani, S. ; Ramezani Tehrani, F. ; Bidhendi Yarandi, R. ; Noroozzadeh, M. ; Hedayati, M. ; Azizi, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-627c82681d365102da8b39a0e78d460eb725476a8604a22d2c5526ce4af3f73b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adipokines - blood</topic><topic>Adiponectin</topic><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>Body Mass Index</topic><topic>Body weight</topic><topic>Case-Control Studies</topic><topic>Cross-Sectional Studies</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Humans</topic><topic>Insulin Resistance</topic><topic>Leptin</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Original Article</topic><topic>Overweight</topic><topic>Polycystic ovary syndrome</topic><topic>Polycystic Ovary Syndrome - blood</topic><topic>Polycystic Ovary Syndrome - etiology</topic><topic>Polycystic Ovary Syndrome - pathology</topic><topic>Serum levels</topic><topic>Statistical analysis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Behboudi-Gandevani, S.</creatorcontrib><creatorcontrib>Ramezani Tehrani, F.</creatorcontrib><creatorcontrib>Bidhendi Yarandi, R.</creatorcontrib><creatorcontrib>Noroozzadeh, M.</creatorcontrib><creatorcontrib>Hedayati, M.</creatorcontrib><creatorcontrib>Azizi, F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Behboudi-Gandevani, S.</au><au>Ramezani Tehrani, F.</au><au>Bidhendi Yarandi, R.</au><au>Noroozzadeh, M.</au><au>Hedayati, M.</au><au>Azizi, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association between polycystic ovary syndrome, obesity, and the serum concentration of adipokines</atitle><jtitle>Journal of endocrinological investigation</jtitle><stitle>J Endocrinol Invest</stitle><addtitle>J Endocrinol Invest</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>40</volume><issue>8</issue><spage>859</spage><epage>866</epage><pages>859-866</pages><issn>1720-8386</issn><issn>0391-4097</issn><eissn>1720-8386</eissn><abstract>Purpose
This study aimed to investigate the interactive effect of polycystic ovary syndrome (PCOS) status and obesity status on the serum levels of adipokines.
Methods
In this comparative case–control cross-sectional study, 58 women with PCOS and 104 eumenorrheic non-hirsute women as the control group were recruited. They were further divided into two subgroups of overweight/obese and normal weight. The interactive effect of the PCOS status and obesity status on the circulating levels of adipokines was assessed using general linear model with the adjustment of age.
Results
A statistically significant negative interaction was reported between obesity status and PCOS status in the determination of serum adiponectin and resistin concentrations (effect size = −0.14, interaction
P
= 0.001, effect size = −0.15,
P
= 0.016). It indicated that adiponectin and resistin were significantly decreased in overweight/obese patients with PCOS compared with other subgroups. Statistically significant positive interactive effects were found between PCOS status obesity status and leptin (effect size = 0.321, interaction
P
= 0.036), indicating that the overweight/obese women with PCOS had the higher levels of leptin compared with the control group. Also, no interaction was reported between PCOS status and obesity status with regard to the serum levels of other adipokines.
Conclusions
While no sufficient evidence is available with regard to the causal association between adipokines and PCOS, they may contribute to the development of PCOS and regarded as the novel biomarkers of PCOS.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>28332170</pmid><doi>10.1007/s40618-017-0650-x</doi><tpages>8</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adipokines - blood Adiponectin Adult Biomarkers - blood Body Mass Index Body weight Case-Control Studies Cross-Sectional Studies Endocrinology Female Humans Insulin Resistance Leptin Medicine Medicine & Public Health Metabolic Diseases Obesity Obesity - complications Original Article Overweight Polycystic ovary syndrome Polycystic Ovary Syndrome - blood Polycystic Ovary Syndrome - etiology Polycystic Ovary Syndrome - pathology Serum levels Statistical analysis Young Adult |
| title | The association between polycystic ovary syndrome, obesity, and the serum concentration of adipokines |
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