NFATc1 with AP-3 Site Binding Specificity Mediates Gene Expression of Prostate-specific-membrane-antigen

Prostate-specific-membrane-antigen (PSMA) is a marker protein expressed primarily in prostate epithelium. Its prostate-specific expression is conferred by PSMA enhancer (PSME), localized within the third intron of PSMA-encoding gene FOLH1. We recently reported that the 5′-end 90 bp of PSME harbored...

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Veröffentlicht in:	Journal of molecular biology 2003-07, Vol.330 (4), p.749-760
Hauptverfasser:	Lee, Sang-Jin, Lee, KangRyul, Yang, Xiumei, Jung, Chaeyong, Gardner, Thomas, Kim, Hong-Sup, Jeng, Meei-Huey, Kao, Chinghai
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Surface AP-1 Base Sequence Binding Sites Binding, Competitive Biotinylation Blotting, Western Calcium - metabolism Carboxypeptidases - biosynthesis Carboxypeptidases - genetics Cell Line Cell Nucleus - metabolism Chromatin - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Electrophoresis, Polyacrylamide Gel Enhancer Elements, Genetic Gene Deletion Glutamate Carboxypeptidase II Humans Jurkat Cells Luciferases - metabolism Male Models, Genetic Molecular Sequence Data Mutagenesis Mutagenesis, Site-Directed Mutation NFATC Transcription Factors NFATc1 Nuclear Proteins Plasmids - metabolism Precipitin Tests prostate cancer Prostatic Neoplasms - chemistry Protein Binding Protein Isoforms PSMA PSME RNA, Small Interfering - metabolism Transcription Factors - chemistry Transcription Factors - metabolism Transcription Factors - physiology Transfection Tumor Cells, Cultured Ultraviolet Rays
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