Inhibition of clastogenicity of benzo[ a]pyrene and of its trans-7,8-dihydrodiol in mice in vivo by fruits, vegetables, and flavonoids

In the in vivo mouse bone marrow micronucleus assay, homogenates of spinach, artichoke, peaches, and blue grapes as well as commercial concentrates of these vegetables and fruits reduced induction of micronuclei by benzo[ a]pyrene (BaP) by 43–50%. Concentrates of strawberries (31% reduction) and of...

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Veröffentlicht in:	Mutation research 2003-06, Vol.537 (2), p.169-181
Hauptverfasser:	Edenharder, R., Krieg, H., Köttgen, V., Platt, K.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Anticlastogenic effects Antimutagenic Agents - pharmacology Benzo(a)pyrene - administration & dosage Benzo(a)pyrene - antagonists & inhibitors Benzo(a)pyrene - toxicity Benzo[ a]pyrene Biological and medical sciences Bone Marrow Cells - drug effects Bone Marrow Cells - pathology Chemical mutagenesis Concentrates Cytochrome P-450 CYP1A1 - antagonists & inhibitors Cytochrome P-450 CYP1A1 - metabolism Cytochrome P-450 CYP2B1 - antagonists & inhibitors Cytochrome P-450 CYP2B1 - metabolism Dihydroxydihydrobenzopyrenes - administration & dosage Dihydroxydihydrobenzopyrenes - antagonists & inhibitors Dihydroxydihydrobenzopyrenes - toxicity Dose-Response Relationship, Drug Drug Therapy, Combination Fruit Fruits Injections, Intraperitoneal Liver - drug effects Liver - enzymology Male Medical sciences Mice Mice, Inbred Strains Micronuclei, Chromosome-Defective - drug effects Micronucleus Tests Mutagens - administration & dosage Mutagens - toxicity Plant Extracts - administration & dosage Plant Extracts - pharmacology Quercetin - analogs & derivatives Quercetin - pharmacology Toxicology Vegetables
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