BK Polyomavirus‐Specific 9mer CD8 T Cell Responses Correlate With Clearance of BK Viremia in Kidney Transplant Recipients: First Report From the Swiss Transplant Cohort Study

BK polyomavirus (BKPyV) causes premature kidney transplant (KT) failure in 1–15% of patients. Because antivirals are lacking, most programs screen for BKPyV‐viremia and, if positive, reduce immunosuppression. To evaluate the relationship of viremia and BKPyV‐specific immunity, we examined prospectiv...

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Veröffentlicht in:	American journal of transplantation 2017-10, Vol.17 (10), p.2591-2600
Hauptverfasser:	Leboeuf, C., Wilk, S., Achermann, R., Binet, I., Golshayan, D., Hadaya, K., Hirzel, C., Hoffmann, M., Huynh‐Do, U., Koller, M. T., Manuel, O., Mueller, N. J., Mueller, T. F., Schaub, S., Delden, C., Weissbach, F. H., Hirsch, H. H., Amico, Patrizia, Aubert, John‐David, Banz, Vanessa, Beldi, Guido, Benden, Christian, Berger, Christoph, Bochud, Pierre‐Yves, Bucher, Heiner, Bühler, Leo, Carell, Thierry, Catana, Emmanuelle, Chalandon, Yves, Geest, Sabina, Rougemont, Olivier, Dickenmann, Michael, Duchosal, Michel, Elkrief, Laure, Fehr, Thomas, Ferrari‐Lacraz, Sylvie, Garzoni, Christian, Soccal, Paola Gasche, Gaudet, Christophe, Giostra, Emiliano, Halter, Jörg, Heim, Dominik, Hess, Christoph, Hillinger, Sven, Hofbauer, Günther, Immer, Franz, Klaghofer, Richard, Laesser, Bettina, Lehmann, Roger, Lovis, Christian, Marti, Hans‐Peter, Martin, Pierre Yves, Meylan, Pascal, Mohacsi, Paul, Morel, Philippe, Mueller, Ulrike, Mueller‐McKenna, Helen, Müller, Antonia, Müller, Thomas, Müllhaupt, Beat, Nadal, David, Pascual, Manuel, Passweg, Jakob, Rick, Juliane, Roosnek, Eddy, Rosselet, Anne, Rothlin, Silvia, Ruschitzka, Frank, Schanz, Urs, Schnyder, Aurelia, Seiler, Christian, Stampf, Susanne, Steiger, Jürg, Stirnimann, Guido, Toso, Christian, Venetz, Jean‐Pierre, Villard, Jean, Wick, Madeleine, Wilhelm, Markus, Yerly, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged antigen presentation/recognition Antiviral agents Antiviral drugs BK Virus - isolation & purification BK Virus - physiology Case-Control Studies CD8 antigen CD8-Positive T-Lymphocytes - immunology Cohort analysis Cohort Studies Cryopreservation Enzyme-linked immunosorbent assay Epitopes Female Histocompatibility antigen HLA Humans Immunoglobulin G Immunosuppression infection and infectious agents infectious disease Kidney transplantation Kidney Transplantation - adverse effects kidney transplantation/nephrology Kidney transplants Leukocytes (mononuclear) Lymphocytes Lymphocytes T Male Middle Aged Peripheral blood mononuclear cells Renal failure Serology T cell biology T cell receptors translational research/science Transplantation Transplants & implants viral: BK/JC/polyoma Viremia
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