Very long-term sequelae of craniopharyngioma
Objective Studies investigating long-term health conditions in patients with craniopharyngioma are limited by short follow-up durations and generally do not compare long-term health effects according to initial craniopharyngioma treatment approach. In addition, studies comparing long-term health con...
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| Veröffentlicht in: | European journal of endocrinology 2017-06, Vol.176 (6), p.755-767 |
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| creator | Wijnen, Mark van den Heuvel-Eibrink, Marry M Janssen, Joseph A M J L Catsman-Berrevoets, Coriene E Michiels, Erna M C van Veelen-Vincent, Marie-Lise C Dallenga, Alof H G van den Berge, J Herbert van Rij, Carolien M van der Lely, Aart-Jan Neggers, Sebastian J C M M |
| description | Objective Studies investigating long-term health conditions in patients with craniopharyngioma are limited by short follow-up durations and generally do not compare long-term health effects according to initial craniopharyngioma treatment approach. In addition, studies comparing long-term health conditions between patients with childhood- and adult-onset craniopharyngioma report conflicting results. The objective of this study was to analyse a full spectrum of long-term health effects in patients with craniopharyngioma according to initial treatment approach and age group at craniopharyngioma presentation. Design Cross-sectional study based on retrospective data. Methods We studied a single-centre cohort of 128 patients with craniopharyngioma treated from 1980 onwards (63 patients with childhood-onset disease). Median follow-up since craniopharyngioma presentation was 13 years (interquartile range: 5–23 years). Initial craniopharyngioma treatment approaches included gross total resection (n = 25), subtotal resection without radiotherapy (n = 44), subtotal resection with radiotherapy (n = 25), cyst aspiration without radiotherapy (n = 8), and 90Yttrium brachytherapy (n = 21). Results Pituitary hormone deficiencies (98%), visual disturbances (75%) and obesity (56%) were the most common long-term health conditions observed. Different initial craniopharyngioma treatment approaches resulted in similar long-term health effects. Patients with childhood-onset craniopharyngioma experienced significantly more growth hormone deficiency, diabetes insipidus, panhypopituitarism, morbid obesity, epilepsy and psychiatric conditions compared with patients with adult-onset disease. Recurrence-/progression-free survival was significantly lower after initial craniopharyngioma treatment with cyst aspiration compared with other therapeutic approaches. Survival was similar between patients with childhood- and adult-onset craniopharyngioma. Conclusions Long-term health conditions were comparable after different initial craniopharyngioma treatment approaches and were generally more frequent in patients with childhood- compared with adult-onset disease. |
| doi_str_mv | 10.1530/EJE-17-0044 |
| format | Article |
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In addition, studies comparing long-term health conditions between patients with childhood- and adult-onset craniopharyngioma report conflicting results. The objective of this study was to analyse a full spectrum of long-term health effects in patients with craniopharyngioma according to initial treatment approach and age group at craniopharyngioma presentation. Design Cross-sectional study based on retrospective data. Methods We studied a single-centre cohort of 128 patients with craniopharyngioma treated from 1980 onwards (63 patients with childhood-onset disease). Median follow-up since craniopharyngioma presentation was 13 years (interquartile range: 5–23 years). Initial craniopharyngioma treatment approaches included gross total resection (n = 25), subtotal resection without radiotherapy (n = 44), subtotal resection with radiotherapy (n = 25), cyst aspiration without radiotherapy (n = 8), and 90Yttrium brachytherapy (n = 21). Results Pituitary hormone deficiencies (98%), visual disturbances (75%) and obesity (56%) were the most common long-term health conditions observed. Different initial craniopharyngioma treatment approaches resulted in similar long-term health effects. Patients with childhood-onset craniopharyngioma experienced significantly more growth hormone deficiency, diabetes insipidus, panhypopituitarism, morbid obesity, epilepsy and psychiatric conditions compared with patients with adult-onset disease. Recurrence-/progression-free survival was significantly lower after initial craniopharyngioma treatment with cyst aspiration compared with other therapeutic approaches. Survival was similar between patients with childhood- and adult-onset craniopharyngioma. Conclusions Long-term health conditions were comparable after different initial craniopharyngioma treatment approaches and were generally more frequent in patients with childhood- compared with adult-onset disease.</description><identifier>ISSN: 0804-4643</identifier><identifier>EISSN: 1479-683X</identifier><identifier>DOI: 10.1530/EJE-17-0044</identifier><identifier>PMID: 28325825</identifier><language>eng</language><publisher>England: Bioscientifica Ltd</publisher><subject>Age of Onset ; Aging ; Brachytherapy ; Child ; Child, Preschool ; Children ; Clinical Study ; Cohort Studies ; Combined Modality Therapy - adverse effects ; Complications ; Craniopharyngioma - complications ; Craniopharyngioma - physiopathology ; Craniopharyngioma - surgery ; Craniopharyngioma - therapy ; Cross-Sectional Studies ; Cysts ; Diabetes insipidus ; Epilepsy ; Female ; Follow-Up Studies ; Growth hormones ; Humans ; Hypopituitarism - epidemiology ; Hypopituitarism - etiology ; Male ; Neoplasia ; Neoplasm Recurrence, Local - epidemiology ; Neoplasm Recurrence, Local - prevention & control ; Netherlands - epidemiology ; Obesity ; Obesity - complications ; Obesity - epidemiology ; Patients ; Pituitary ; Pituitary hormones ; Pituitary Neoplasms - physiopathology ; Pituitary Neoplasms - surgery ; Pituitary Neoplasms - therapy ; Prevalence ; Radiation therapy ; Retrospective Studies ; Risk ; Survival ; Survival Analysis ; Vision Disorders - epidemiology ; Vision Disorders - etiology</subject><ispartof>European journal of endocrinology, 2017-06, Vol.176 (6), p.755-767</ispartof><rights>2017 European Society of Endocrinology</rights><rights>2017 European Society of Endocrinology.</rights><rights>Copyright BioScientifica Ltd. Jun 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b504t-b69fb2829756fa06e3502cdd8fc1704f914dba593a34c8cea4fabf94610409623</citedby><cites>FETCH-LOGICAL-b504t-b69fb2829756fa06e3502cdd8fc1704f914dba593a34c8cea4fabf94610409623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28325825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wijnen, Mark</creatorcontrib><creatorcontrib>van den Heuvel-Eibrink, Marry M</creatorcontrib><creatorcontrib>Janssen, Joseph A M J L</creatorcontrib><creatorcontrib>Catsman-Berrevoets, Coriene E</creatorcontrib><creatorcontrib>Michiels, Erna M C</creatorcontrib><creatorcontrib>van Veelen-Vincent, Marie-Lise C</creatorcontrib><creatorcontrib>Dallenga, Alof H G</creatorcontrib><creatorcontrib>van den Berge, J Herbert</creatorcontrib><creatorcontrib>van Rij, Carolien M</creatorcontrib><creatorcontrib>van der Lely, Aart-Jan</creatorcontrib><creatorcontrib>Neggers, Sebastian J C M M</creatorcontrib><title>Very long-term sequelae of craniopharyngioma</title><title>European journal of endocrinology</title><addtitle>Eur J Endocrinol</addtitle><description>Objective Studies investigating long-term health conditions in patients with craniopharyngioma are limited by short follow-up durations and generally do not compare long-term health effects according to initial craniopharyngioma treatment approach. In addition, studies comparing long-term health conditions between patients with childhood- and adult-onset craniopharyngioma report conflicting results. The objective of this study was to analyse a full spectrum of long-term health effects in patients with craniopharyngioma according to initial treatment approach and age group at craniopharyngioma presentation. Design Cross-sectional study based on retrospective data. Methods We studied a single-centre cohort of 128 patients with craniopharyngioma treated from 1980 onwards (63 patients with childhood-onset disease). Median follow-up since craniopharyngioma presentation was 13 years (interquartile range: 5–23 years). Initial craniopharyngioma treatment approaches included gross total resection (n = 25), subtotal resection without radiotherapy (n = 44), subtotal resection with radiotherapy (n = 25), cyst aspiration without radiotherapy (n = 8), and 90Yttrium brachytherapy (n = 21). Results Pituitary hormone deficiencies (98%), visual disturbances (75%) and obesity (56%) were the most common long-term health conditions observed. Different initial craniopharyngioma treatment approaches resulted in similar long-term health effects. Patients with childhood-onset craniopharyngioma experienced significantly more growth hormone deficiency, diabetes insipidus, panhypopituitarism, morbid obesity, epilepsy and psychiatric conditions compared with patients with adult-onset disease. Recurrence-/progression-free survival was significantly lower after initial craniopharyngioma treatment with cyst aspiration compared with other therapeutic approaches. Survival was similar between patients with childhood- and adult-onset craniopharyngioma. Conclusions Long-term health conditions were comparable after different initial craniopharyngioma treatment approaches and were generally more frequent in patients with childhood- compared with adult-onset disease.</description><subject>Age of Onset</subject><subject>Aging</subject><subject>Brachytherapy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Clinical Study</subject><subject>Cohort Studies</subject><subject>Combined Modality Therapy - adverse effects</subject><subject>Complications</subject><subject>Craniopharyngioma - complications</subject><subject>Craniopharyngioma - physiopathology</subject><subject>Craniopharyngioma - surgery</subject><subject>Craniopharyngioma - therapy</subject><subject>Cross-Sectional Studies</subject><subject>Cysts</subject><subject>Diabetes insipidus</subject><subject>Epilepsy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Growth hormones</subject><subject>Humans</subject><subject>Hypopituitarism - epidemiology</subject><subject>Hypopituitarism - etiology</subject><subject>Male</subject><subject>Neoplasia</subject><subject>Neoplasm Recurrence, Local - epidemiology</subject><subject>Neoplasm Recurrence, Local - prevention & control</subject><subject>Netherlands - epidemiology</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - epidemiology</subject><subject>Patients</subject><subject>Pituitary</subject><subject>Pituitary hormones</subject><subject>Pituitary Neoplasms - physiopathology</subject><subject>Pituitary Neoplasms - surgery</subject><subject>Pituitary Neoplasms - therapy</subject><subject>Prevalence</subject><subject>Radiation therapy</subject><subject>Retrospective Studies</subject><subject>Risk</subject><subject>Survival</subject><subject>Survival Analysis</subject><subject>Vision Disorders - epidemiology</subject><subject>Vision Disorders - etiology</subject><issn>0804-4643</issn><issn>1479-683X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90DtPwzAUBWALgWh5TOyoEgsSBK5jO7FHVJWXKrEAYrMcxy6ukrjYydB_j6sWBgYm3-HT0fFB6AzDDWYEbmfPswyXGQCle2iMaSmygpOPfTQGDjSjBSUjdBTjEgCnGw7RKOckZzxnY3T9bsJ60vhukfUmtJNovgbTKDPxdqKD6pxffaqw7hbOt-oEHVjVRHO6e4_R2_3sdfqYzV8enqZ386xiQPusKoStcp6LkhVWQWEIg1zXNbcal0CtwLSuFBNEEaq5NopaVVlBCwwURJGTY3S5zV0Fn-rEXrYuatM0qjN-iBJzDsAZoyLRiz906YfQpXYyB1JCKoR5UldbpYOPMRgrV8G16V8Sg9yMKNOIEpdyM2LS57vMoWpN_Wt_VksAb0HlfNTOdL2zTqt_Q78BvOJ6aQ</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>Wijnen, Mark</creator><creator>van den Heuvel-Eibrink, Marry M</creator><creator>Janssen, Joseph A M J L</creator><creator>Catsman-Berrevoets, Coriene E</creator><creator>Michiels, Erna M C</creator><creator>van Veelen-Vincent, Marie-Lise C</creator><creator>Dallenga, Alof H G</creator><creator>van den Berge, J Herbert</creator><creator>van Rij, Carolien M</creator><creator>van der Lely, Aart-Jan</creator><creator>Neggers, Sebastian J C M M</creator><general>Bioscientifica Ltd</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>201706</creationdate><title>Very long-term sequelae of craniopharyngioma</title><author>Wijnen, Mark ; van den Heuvel-Eibrink, Marry M ; Janssen, Joseph A M J L ; Catsman-Berrevoets, Coriene E ; Michiels, Erna M C ; van Veelen-Vincent, Marie-Lise C ; Dallenga, Alof H G ; van den Berge, J Herbert ; van Rij, Carolien M ; van der Lely, Aart-Jan ; Neggers, Sebastian J C M M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b504t-b69fb2829756fa06e3502cdd8fc1704f914dba593a34c8cea4fabf94610409623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Age of Onset</topic><topic>Aging</topic><topic>Brachytherapy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Clinical Study</topic><topic>Cohort Studies</topic><topic>Combined Modality Therapy - adverse effects</topic><topic>Complications</topic><topic>Craniopharyngioma - complications</topic><topic>Craniopharyngioma - physiopathology</topic><topic>Craniopharyngioma - surgery</topic><topic>Craniopharyngioma - therapy</topic><topic>Cross-Sectional Studies</topic><topic>Cysts</topic><topic>Diabetes insipidus</topic><topic>Epilepsy</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Growth hormones</topic><topic>Humans</topic><topic>Hypopituitarism - epidemiology</topic><topic>Hypopituitarism - etiology</topic><topic>Male</topic><topic>Neoplasia</topic><topic>Neoplasm Recurrence, Local - epidemiology</topic><topic>Neoplasm Recurrence, Local - prevention & control</topic><topic>Netherlands - epidemiology</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Obesity - epidemiology</topic><topic>Patients</topic><topic>Pituitary</topic><topic>Pituitary hormones</topic><topic>Pituitary Neoplasms - physiopathology</topic><topic>Pituitary Neoplasms - surgery</topic><topic>Pituitary Neoplasms - therapy</topic><topic>Prevalence</topic><topic>Radiation therapy</topic><topic>Retrospective Studies</topic><topic>Risk</topic><topic>Survival</topic><topic>Survival Analysis</topic><topic>Vision Disorders - epidemiology</topic><topic>Vision Disorders - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wijnen, Mark</creatorcontrib><creatorcontrib>van den Heuvel-Eibrink, Marry M</creatorcontrib><creatorcontrib>Janssen, Joseph A M J L</creatorcontrib><creatorcontrib>Catsman-Berrevoets, Coriene E</creatorcontrib><creatorcontrib>Michiels, Erna M C</creatorcontrib><creatorcontrib>van Veelen-Vincent, Marie-Lise C</creatorcontrib><creatorcontrib>Dallenga, Alof H G</creatorcontrib><creatorcontrib>van den Berge, J Herbert</creatorcontrib><creatorcontrib>van Rij, Carolien M</creatorcontrib><creatorcontrib>van der Lely, Aart-Jan</creatorcontrib><creatorcontrib>Neggers, Sebastian J C M M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wijnen, Mark</au><au>van den Heuvel-Eibrink, Marry M</au><au>Janssen, Joseph A M J L</au><au>Catsman-Berrevoets, Coriene E</au><au>Michiels, Erna M C</au><au>van Veelen-Vincent, Marie-Lise C</au><au>Dallenga, Alof H G</au><au>van den Berge, J Herbert</au><au>van Rij, Carolien M</au><au>van der Lely, Aart-Jan</au><au>Neggers, Sebastian J C M M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Very long-term sequelae of craniopharyngioma</atitle><jtitle>European journal of endocrinology</jtitle><addtitle>Eur J Endocrinol</addtitle><date>2017-06</date><risdate>2017</risdate><volume>176</volume><issue>6</issue><spage>755</spage><epage>767</epage><pages>755-767</pages><issn>0804-4643</issn><eissn>1479-683X</eissn><abstract>Objective Studies investigating long-term health conditions in patients with craniopharyngioma are limited by short follow-up durations and generally do not compare long-term health effects according to initial craniopharyngioma treatment approach. In addition, studies comparing long-term health conditions between patients with childhood- and adult-onset craniopharyngioma report conflicting results. The objective of this study was to analyse a full spectrum of long-term health effects in patients with craniopharyngioma according to initial treatment approach and age group at craniopharyngioma presentation. Design Cross-sectional study based on retrospective data. Methods We studied a single-centre cohort of 128 patients with craniopharyngioma treated from 1980 onwards (63 patients with childhood-onset disease). Median follow-up since craniopharyngioma presentation was 13 years (interquartile range: 5–23 years). Initial craniopharyngioma treatment approaches included gross total resection (n = 25), subtotal resection without radiotherapy (n = 44), subtotal resection with radiotherapy (n = 25), cyst aspiration without radiotherapy (n = 8), and 90Yttrium brachytherapy (n = 21). Results Pituitary hormone deficiencies (98%), visual disturbances (75%) and obesity (56%) were the most common long-term health conditions observed. Different initial craniopharyngioma treatment approaches resulted in similar long-term health effects. Patients with childhood-onset craniopharyngioma experienced significantly more growth hormone deficiency, diabetes insipidus, panhypopituitarism, morbid obesity, epilepsy and psychiatric conditions compared with patients with adult-onset disease. Recurrence-/progression-free survival was significantly lower after initial craniopharyngioma treatment with cyst aspiration compared with other therapeutic approaches. Survival was similar between patients with childhood- and adult-onset craniopharyngioma. Conclusions Long-term health conditions were comparable after different initial craniopharyngioma treatment approaches and were generally more frequent in patients with childhood- compared with adult-onset disease.</abstract><cop>England</cop><pub>Bioscientifica Ltd</pub><pmid>28325825</pmid><doi>10.1530/EJE-17-0044</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age of Onset Aging Brachytherapy Child Child, Preschool Children Clinical Study Cohort Studies Combined Modality Therapy - adverse effects Complications Craniopharyngioma - complications Craniopharyngioma - physiopathology Craniopharyngioma - surgery Craniopharyngioma - therapy Cross-Sectional Studies Cysts Diabetes insipidus Epilepsy Female Follow-Up Studies Growth hormones Humans Hypopituitarism - epidemiology Hypopituitarism - etiology Male Neoplasia Neoplasm Recurrence, Local - epidemiology Neoplasm Recurrence, Local - prevention & control Netherlands - epidemiology Obesity Obesity - complications Obesity - epidemiology Patients Pituitary Pituitary hormones Pituitary Neoplasms - physiopathology Pituitary Neoplasms - surgery Pituitary Neoplasms - therapy Prevalence Radiation therapy Retrospective Studies Risk Survival Survival Analysis Vision Disorders - epidemiology Vision Disorders - etiology |
| title | Very long-term sequelae of craniopharyngioma |
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