Vasoprotective Activities of the Adrenomedullin-RAMP2 System in Endothelial Cells

Neointimal hyperplasia is the primary lesion underlying atherosclerosis and restenosis after coronary intervention. We previously described the essential angiogenic function of the adrenomedullin (AM)-receptor activity-modifying protein (RAMP) 2 system. In the present study, we assessed the vasoprot...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2017-05, Vol.158 (5), p.1359-1372
Hauptverfasser:	Xian, Xian, Sakurai, Takayuki, Kamiyoshi, Akiko, Ichikawa-Shindo, Yuka, Tanaka, Megumu, Koyama, Teruhide, Kawate, Hisaka, Yang, Lei, Liu, Tian, Imai, Akira, Zhai, Liuyu, Hirabayashi, Kazutaka, Dai, Kun, Tanimura, Keiya, Liu, Teng, Cui, Nanqi, Igarashi, Kyoko, Yamauchi, Akihiro, Shindo, Takayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenomedullin Adrenomedullin - genetics Adrenomedullin - physiology Angiogenesis Animals Arteriosclerosis Atherosclerosis Blood vessels Bone growth Bone marrow Bone marrow transplantation Cell proliferation Cells (biology) Cells, Cultured Clonal deletion Cytoprotection - genetics Endocrinology Endothelial cells Endothelial Cells - physiology Femoral Artery - injuries Femoral Artery - metabolism Femoral Artery - pathology Humans Hyperplasia Infiltration Inflammation Injuries Leukocyte migration Macrophages Male Males Medical treatment Mice Mice, Inbred C57BL Mice, Knockout Muscles Neointima - genetics Neointima - metabolism Neointima - pathology Oxidative stress Progenitor cells Receptor activity modifying proteins Receptor Activity-Modifying Protein 2 - genetics Receptor Activity-Modifying Protein 2 - physiology Restenosis Rodents Signal Transduction - genetics Smooth muscle Stem cells Therapeutic targets Transplants Vascular diseases Vascular System Injuries - genetics Vascular System Injuries - prevention & control
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