Metabolically Healthy Obesity and Ischemic Heart Disease: A 10-Year Follow-Up of the Inter99 Study
Abstract Context: Recent studies have suggested that a subgroup of obese individuals is not at increased risk of obesity-related complications. This subgroup has been referred to as metabolically healthy obese. Objective: To investigate whether obesity is a risk factor for development of ischemic he...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2017-06, Vol.102 (6), p.1934-1942 |
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| container_title | The journal of clinical endocrinology and metabolism |
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| creator | Hansen, Louise Netterstrøm, Marie K. Johansen, Nanna B. Rønn, Pernille F. Vistisen, Dorte Husemoen, Lise L. N. Jørgensen, Marit E. Rod, Naja H. Færch, Kristine |
| description | Abstract
Context:
Recent studies have suggested that a subgroup of obese individuals is not at increased risk of obesity-related complications. This subgroup has been referred to as metabolically healthy obese.
Objective:
To investigate whether obesity is a risk factor for development of ischemic heart disease (IHD) irrespective of metabolic health.
Design:
In all, 6238 men and women from the Danish prospective Inter99 study were followed during 10.6 (standard deviation = 1.7) years.
Setting:
General community.
Participants:
Participants were classified according to body mass index and four metabolic risk factors (low high-density lipoprotein cholesterol, elevated blood pressure, triglycerides, and fasting plasma glucose). Metabolically healthy individuals were defined as having no metabolic risk factors, and metabolically unhealthy individuals were defined as having a minimum of one.
Main Outcome Measures:
IHD.
Results:
During follow-up, 323 participants developed IHD. Metabolically healthy obese men had increased risk of IHD compared with metabolically healthy normal-weight men [hazard ratio (HR), 3.1; 95% confidence interval (CI), 1.1 to 8.2)]. The corresponding results for women were less pronounced (HR, 1.8; 95% CI, 0.7 to 4.8). Being metabolically healthy but overweight was not associated with higher risk of IHD in men (HR, 1.1; 95% CI, 0.5 to 2.4), and in women the risk was only slightly increased and insignificant (HR, 1.5; 95% CI, 0.8 to 3.0). A substantial proportion of metabolically healthy individuals became metabolically unhealthy after 5 years of follow-up. When these changes in exposure status were taken into account, slightly higher risk estimates were found.
Conclusions:
Being obese is associated with higher incidence of IHD irrespective of metabolic status, and we question the feasibility of denoting a subgroup of obese individuals as metabolically healthy.
We studied the risk of ischemic heart disease (IHD) in the Inter99 cohort and found that metabolically healthy obese men had increased risk of IHD compared with metabolically healthy normal-weight men. |
| doi_str_mv | 10.1210/jc.2016-3346 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1880084567</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1210/jc.2016-3346</oup_id><sourcerecordid>1880084567</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5009-c99fec330c1a37c73b02ba795003d9786e9536c236ba542ac059a80cd6851a093</originalsourceid><addsrcrecordid>eNp1kc1LHDEUwINYdKu9eS4BD-2h0ZePSSa9idW6YPHQCvUUMpksO9vsZpvMsMx_b8a1PRR6CCHv_d4HvyB0RuGCMgqXK3fBgErCuZAHaEa1qIiiWh2iGQCjRCv28xi9zXkFQIWo-BE6ZjVnXGs9Q80339smhs7ZEEZ8523olyN-aHzu-hHbTYvn2S39unNTMvX4S5e9zf4zvsIUyFOJ4dsYQtyRxy2OC9wvPZ5vep-0xt_7oR1P0ZuFDdm_e71P0OPtzY_rO3L_8HV-fXVPXAWgidN64R3n4KjlyineAGus0iXJW61q6XXFpWNcNrYSzDqotK3BtbKuqAXNT9DHfd9tir8Hn3uz7rLzIdiNj0M2tK4BalFJVdDzf9BVHNKmbGeKOSgThZSF-rSnXIo5J78w29StbRoNBTO5NytnJvdmcl_w969Nh2bt27_wH9kFEHtgF0Pxk3-FYeeTWb44N2UqCKlqUjoqkOVFyqFT2Yd9WRy2_9vg5ff5M1DilyY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1970003466</pqid></control><display><type>article</type><title>Metabolically Healthy Obesity and Ischemic Heart Disease: A 10-Year Follow-Up of the Inter99 Study</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><source>Journals@Ovid Complete</source><source>ProQuest Central</source><creator>Hansen, Louise ; Netterstrøm, Marie K. ; Johansen, Nanna B. ; Rønn, Pernille F. ; Vistisen, Dorte ; Husemoen, Lise L. N. ; Jørgensen, Marit E. ; Rod, Naja H. ; Færch, Kristine</creator><creatorcontrib>Hansen, Louise ; Netterstrøm, Marie K. ; Johansen, Nanna B. ; Rønn, Pernille F. ; Vistisen, Dorte ; Husemoen, Lise L. N. ; Jørgensen, Marit E. ; Rod, Naja H. ; Færch, Kristine</creatorcontrib><description>Abstract
Context:
Recent studies have suggested that a subgroup of obese individuals is not at increased risk of obesity-related complications. This subgroup has been referred to as metabolically healthy obese.
Objective:
To investigate whether obesity is a risk factor for development of ischemic heart disease (IHD) irrespective of metabolic health.
Design:
In all, 6238 men and women from the Danish prospective Inter99 study were followed during 10.6 (standard deviation = 1.7) years.
Setting:
General community.
Participants:
Participants were classified according to body mass index and four metabolic risk factors (low high-density lipoprotein cholesterol, elevated blood pressure, triglycerides, and fasting plasma glucose). Metabolically healthy individuals were defined as having no metabolic risk factors, and metabolically unhealthy individuals were defined as having a minimum of one.
Main Outcome Measures:
IHD.
Results:
During follow-up, 323 participants developed IHD. Metabolically healthy obese men had increased risk of IHD compared with metabolically healthy normal-weight men [hazard ratio (HR), 3.1; 95% confidence interval (CI), 1.1 to 8.2)]. The corresponding results for women were less pronounced (HR, 1.8; 95% CI, 0.7 to 4.8). Being metabolically healthy but overweight was not associated with higher risk of IHD in men (HR, 1.1; 95% CI, 0.5 to 2.4), and in women the risk was only slightly increased and insignificant (HR, 1.5; 95% CI, 0.8 to 3.0). A substantial proportion of metabolically healthy individuals became metabolically unhealthy after 5 years of follow-up. When these changes in exposure status were taken into account, slightly higher risk estimates were found.
Conclusions:
Being obese is associated with higher incidence of IHD irrespective of metabolic status, and we question the feasibility of denoting a subgroup of obese individuals as metabolically healthy.
We studied the risk of ischemic heart disease (IHD) in the Inter99 cohort and found that metabolically healthy obese men had increased risk of IHD compared with metabolically healthy normal-weight men.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2016-3346</identifier><identifier>PMID: 28323999</identifier><language>eng</language><publisher>Washington, DC: Endocrine Society</publisher><subject>Adult ; Blood Glucose - metabolism ; Blood Pressure ; Body mass ; Body Mass Index ; Body weight ; Cardiovascular disease ; Cholesterol ; Cholesterol, LDL - metabolism ; Complications ; Coronary artery disease ; Denmark - epidemiology ; Feasibility studies ; Female ; Follow-Up Studies ; Health risk assessment ; Health risks ; Heart diseases ; Humans ; Hypertension - epidemiology ; Ischemia ; Male ; Metabolism ; Middle Aged ; Myocardial Ischemia - epidemiology ; Obesity ; Obesity - epidemiology ; Obesity - metabolism ; Obesity, Metabolically Benign - epidemiology ; Obesity, Metabolically Benign - metabolism ; Overweight ; Proportional Hazards Models ; Prospective Studies ; Risk Factors ; Triglycerides ; Triglycerides - metabolism ; Women</subject><ispartof>The journal of clinical endocrinology and metabolism, 2017-06, Vol.102 (6), p.1934-1942</ispartof><rights>Copyright © 2017 Endocrine Society 2017</rights><rights>Copyright © Oxford University Press 2015</rights><rights>Copyright © 2017 Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5009-c99fec330c1a37c73b02ba795003d9786e9536c236ba542ac059a80cd6851a093</citedby><cites>FETCH-LOGICAL-c5009-c99fec330c1a37c73b02ba795003d9786e9536c236ba542ac059a80cd6851a093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1970003466?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,21367,27901,27902,33721,33722,43781</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28323999$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hansen, Louise</creatorcontrib><creatorcontrib>Netterstrøm, Marie K.</creatorcontrib><creatorcontrib>Johansen, Nanna B.</creatorcontrib><creatorcontrib>Rønn, Pernille F.</creatorcontrib><creatorcontrib>Vistisen, Dorte</creatorcontrib><creatorcontrib>Husemoen, Lise L. N.</creatorcontrib><creatorcontrib>Jørgensen, Marit E.</creatorcontrib><creatorcontrib>Rod, Naja H.</creatorcontrib><creatorcontrib>Færch, Kristine</creatorcontrib><title>Metabolically Healthy Obesity and Ischemic Heart Disease: A 10-Year Follow-Up of the Inter99 Study</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Abstract
Context:
Recent studies have suggested that a subgroup of obese individuals is not at increased risk of obesity-related complications. This subgroup has been referred to as metabolically healthy obese.
Objective:
To investigate whether obesity is a risk factor for development of ischemic heart disease (IHD) irrespective of metabolic health.
Design:
In all, 6238 men and women from the Danish prospective Inter99 study were followed during 10.6 (standard deviation = 1.7) years.
Setting:
General community.
Participants:
Participants were classified according to body mass index and four metabolic risk factors (low high-density lipoprotein cholesterol, elevated blood pressure, triglycerides, and fasting plasma glucose). Metabolically healthy individuals were defined as having no metabolic risk factors, and metabolically unhealthy individuals were defined as having a minimum of one.
Main Outcome Measures:
IHD.
Results:
During follow-up, 323 participants developed IHD. Metabolically healthy obese men had increased risk of IHD compared with metabolically healthy normal-weight men [hazard ratio (HR), 3.1; 95% confidence interval (CI), 1.1 to 8.2)]. The corresponding results for women were less pronounced (HR, 1.8; 95% CI, 0.7 to 4.8). Being metabolically healthy but overweight was not associated with higher risk of IHD in men (HR, 1.1; 95% CI, 0.5 to 2.4), and in women the risk was only slightly increased and insignificant (HR, 1.5; 95% CI, 0.8 to 3.0). A substantial proportion of metabolically healthy individuals became metabolically unhealthy after 5 years of follow-up. When these changes in exposure status were taken into account, slightly higher risk estimates were found.
Conclusions:
Being obese is associated with higher incidence of IHD irrespective of metabolic status, and we question the feasibility of denoting a subgroup of obese individuals as metabolically healthy.
We studied the risk of ischemic heart disease (IHD) in the Inter99 cohort and found that metabolically healthy obese men had increased risk of IHD compared with metabolically healthy normal-weight men.</description><subject>Adult</subject><subject>Blood Glucose - metabolism</subject><subject>Blood Pressure</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Body weight</subject><subject>Cardiovascular disease</subject><subject>Cholesterol</subject><subject>Cholesterol, LDL - metabolism</subject><subject>Complications</subject><subject>Coronary artery disease</subject><subject>Denmark - epidemiology</subject><subject>Feasibility studies</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Hypertension - epidemiology</subject><subject>Ischemia</subject><subject>Male</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Myocardial Ischemia - epidemiology</subject><subject>Obesity</subject><subject>Obesity - epidemiology</subject><subject>Obesity - metabolism</subject><subject>Obesity, Metabolically Benign - epidemiology</subject><subject>Obesity, Metabolically Benign - metabolism</subject><subject>Overweight</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Triglycerides</subject><subject>Triglycerides - metabolism</subject><subject>Women</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kc1LHDEUwINYdKu9eS4BD-2h0ZePSSa9idW6YPHQCvUUMpksO9vsZpvMsMx_b8a1PRR6CCHv_d4HvyB0RuGCMgqXK3fBgErCuZAHaEa1qIiiWh2iGQCjRCv28xi9zXkFQIWo-BE6ZjVnXGs9Q80339smhs7ZEEZ8523olyN-aHzu-hHbTYvn2S39unNTMvX4S5e9zf4zvsIUyFOJ4dsYQtyRxy2OC9wvPZ5vep-0xt_7oR1P0ZuFDdm_e71P0OPtzY_rO3L_8HV-fXVPXAWgidN64R3n4KjlyineAGus0iXJW61q6XXFpWNcNrYSzDqotK3BtbKuqAXNT9DHfd9tir8Hn3uz7rLzIdiNj0M2tK4BalFJVdDzf9BVHNKmbGeKOSgThZSF-rSnXIo5J78w29StbRoNBTO5NytnJvdmcl_w969Nh2bt27_wH9kFEHtgF0Pxk3-FYeeTWb44N2UqCKlqUjoqkOVFyqFT2Yd9WRy2_9vg5ff5M1DilyY</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>Hansen, Louise</creator><creator>Netterstrøm, Marie K.</creator><creator>Johansen, Nanna B.</creator><creator>Rønn, Pernille F.</creator><creator>Vistisen, Dorte</creator><creator>Husemoen, Lise L. N.</creator><creator>Jørgensen, Marit E.</creator><creator>Rod, Naja H.</creator><creator>Færch, Kristine</creator><general>Endocrine Society</general><general>Copyright Oxford University Press</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201706</creationdate><title>Metabolically Healthy Obesity and Ischemic Heart Disease: A 10-Year Follow-Up of the Inter99 Study</title><author>Hansen, Louise ; Netterstrøm, Marie K. ; Johansen, Nanna B. ; Rønn, Pernille F. ; Vistisen, Dorte ; Husemoen, Lise L. N. ; Jørgensen, Marit E. ; Rod, Naja H. ; Færch, Kristine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5009-c99fec330c1a37c73b02ba795003d9786e9536c236ba542ac059a80cd6851a093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Blood Glucose - metabolism</topic><topic>Blood Pressure</topic><topic>Body mass</topic><topic>Body Mass Index</topic><topic>Body weight</topic><topic>Cardiovascular disease</topic><topic>Cholesterol</topic><topic>Cholesterol, LDL - metabolism</topic><topic>Complications</topic><topic>Coronary artery disease</topic><topic>Denmark - epidemiology</topic><topic>Feasibility studies</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>Hypertension - epidemiology</topic><topic>Ischemia</topic><topic>Male</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Myocardial Ischemia - epidemiology</topic><topic>Obesity</topic><topic>Obesity - epidemiology</topic><topic>Obesity - metabolism</topic><topic>Obesity, Metabolically Benign - epidemiology</topic><topic>Obesity, Metabolically Benign - metabolism</topic><topic>Overweight</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Triglycerides</topic><topic>Triglycerides - metabolism</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hansen, Louise</creatorcontrib><creatorcontrib>Netterstrøm, Marie K.</creatorcontrib><creatorcontrib>Johansen, Nanna B.</creatorcontrib><creatorcontrib>Rønn, Pernille F.</creatorcontrib><creatorcontrib>Vistisen, Dorte</creatorcontrib><creatorcontrib>Husemoen, Lise L. N.</creatorcontrib><creatorcontrib>Jørgensen, Marit E.</creatorcontrib><creatorcontrib>Rod, Naja H.</creatorcontrib><creatorcontrib>Færch, Kristine</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hansen, Louise</au><au>Netterstrøm, Marie K.</au><au>Johansen, Nanna B.</au><au>Rønn, Pernille F.</au><au>Vistisen, Dorte</au><au>Husemoen, Lise L. N.</au><au>Jørgensen, Marit E.</au><au>Rod, Naja H.</au><au>Færch, Kristine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolically Healthy Obesity and Ischemic Heart Disease: A 10-Year Follow-Up of the Inter99 Study</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2017-06</date><risdate>2017</risdate><volume>102</volume><issue>6</issue><spage>1934</spage><epage>1942</epage><pages>1934-1942</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><abstract>Abstract
Context:
Recent studies have suggested that a subgroup of obese individuals is not at increased risk of obesity-related complications. This subgroup has been referred to as metabolically healthy obese.
Objective:
To investigate whether obesity is a risk factor for development of ischemic heart disease (IHD) irrespective of metabolic health.
Design:
In all, 6238 men and women from the Danish prospective Inter99 study were followed during 10.6 (standard deviation = 1.7) years.
Setting:
General community.
Participants:
Participants were classified according to body mass index and four metabolic risk factors (low high-density lipoprotein cholesterol, elevated blood pressure, triglycerides, and fasting plasma glucose). Metabolically healthy individuals were defined as having no metabolic risk factors, and metabolically unhealthy individuals were defined as having a minimum of one.
Main Outcome Measures:
IHD.
Results:
During follow-up, 323 participants developed IHD. Metabolically healthy obese men had increased risk of IHD compared with metabolically healthy normal-weight men [hazard ratio (HR), 3.1; 95% confidence interval (CI), 1.1 to 8.2)]. The corresponding results for women were less pronounced (HR, 1.8; 95% CI, 0.7 to 4.8). Being metabolically healthy but overweight was not associated with higher risk of IHD in men (HR, 1.1; 95% CI, 0.5 to 2.4), and in women the risk was only slightly increased and insignificant (HR, 1.5; 95% CI, 0.8 to 3.0). A substantial proportion of metabolically healthy individuals became metabolically unhealthy after 5 years of follow-up. When these changes in exposure status were taken into account, slightly higher risk estimates were found.
Conclusions:
Being obese is associated with higher incidence of IHD irrespective of metabolic status, and we question the feasibility of denoting a subgroup of obese individuals as metabolically healthy.
We studied the risk of ischemic heart disease (IHD) in the Inter99 cohort and found that metabolically healthy obese men had increased risk of IHD compared with metabolically healthy normal-weight men.</abstract><cop>Washington, DC</cop><pub>Endocrine Society</pub><pmid>28323999</pmid><doi>10.1210/jc.2016-3346</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-972X |
| ispartof | The journal of clinical endocrinology and metabolism, 2017-06, Vol.102 (6), p.1934-1942 |
| issn | 0021-972X 1945-7197 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1880084567 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Journals@Ovid Complete; ProQuest Central |
| subjects | Adult Blood Glucose - metabolism Blood Pressure Body mass Body Mass Index Body weight Cardiovascular disease Cholesterol Cholesterol, LDL - metabolism Complications Coronary artery disease Denmark - epidemiology Feasibility studies Female Follow-Up Studies Health risk assessment Health risks Heart diseases Humans Hypertension - epidemiology Ischemia Male Metabolism Middle Aged Myocardial Ischemia - epidemiology Obesity Obesity - epidemiology Obesity - metabolism Obesity, Metabolically Benign - epidemiology Obesity, Metabolically Benign - metabolism Overweight Proportional Hazards Models Prospective Studies Risk Factors Triglycerides Triglycerides - metabolism Women |
| title | Metabolically Healthy Obesity and Ischemic Heart Disease: A 10-Year Follow-Up of the Inter99 Study |
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