MEN1-Dependent Breast Cancer: Indication for Early Screening? Results From the Dutch MEN1 Study Group
Abstract Objective: Multiple endocrine neoplasia type 1 (MEN1) is associated with an early-onset elevated breast cancer risk. This finding potentially has implications for breast cancer screening for women with MEN1, and therefore it is necessary to assess whether other risk factors are involved to...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2017-06, Vol.102 (6), p.2083-2090 |
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| creator | van Leeuwaarde, Rachel S. Dreijerink, Koen M. Ausems, Margreet G. Beijers, Hanneke J. Dekkers, Olaf M. de Herder, Wouter W. van der Horst-Schrivers, Anouk N. Drent, Madeleine L. Bisschop, Peter H. Havekes, Bas Peeters, Petra H. M. Pijnappel, Ruud M. Vriens, Menno R. Valk, Gerlof D. |
| description | Abstract
Objective:
Multiple endocrine neoplasia type 1 (MEN1) is associated with an early-onset elevated breast cancer risk. This finding potentially has implications for breast cancer screening for women with MEN1, and therefore it is necessary to assess whether other risk factors are involved to identify those at greatest risk.
Design:
A cross-sectional case control study was performed using the Dutch MEN1 cohort, including >90% of the adult Dutch MEN1 population. All women with a confirmed MEN1 mutation received a questionnaire regarding cancer family history and breast cancer–related endocrine and general cancer risk factors.
Results:
A total of 138 of 165 (84%) eligible women with MEN1 completed the questionnaire. Eleven of the 138 women had breast cancer. Another 34 relatives with breast cancer were identified in the families of the included women, of whom 11 were obligate MEN1 carriers, 14 had no MEN1 mutation, and 9 had an unknown MEN1 status. The median age at breast cancer diagnosis of women with MEN1 (n = 22) was 45 years (range, 30 to 80 years), in comparison with 57.5 years (range, 40 to 85 years) in female relatives without MEN1 (n = 14; P = 0.03) and 61.2 years in the Dutch reference population. Known endocrine risk factors and general risk factors were not different for women with and without breast cancer.
Conclusion:
The increased breast cancer risk in MEN1 carriers was not related to other known breast cancer risk factors or familial cancer history, and therefore breast cancer surveillance from the age of 40 years for all women with MEN1 is justifiable.
MEN1 is associated with an early-onset elevated breast cancer risk and is not related to other breast cancer risk factors. Early breast cancer surveillance is justified for all women with MEN1. |
| doi_str_mv | 10.1210/jc.2016-3690 |
| format | Article |
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Objective:
Multiple endocrine neoplasia type 1 (MEN1) is associated with an early-onset elevated breast cancer risk. This finding potentially has implications for breast cancer screening for women with MEN1, and therefore it is necessary to assess whether other risk factors are involved to identify those at greatest risk.
Design:
A cross-sectional case control study was performed using the Dutch MEN1 cohort, including >90% of the adult Dutch MEN1 population. All women with a confirmed MEN1 mutation received a questionnaire regarding cancer family history and breast cancer–related endocrine and general cancer risk factors.
Results:
A total of 138 of 165 (84%) eligible women with MEN1 completed the questionnaire. Eleven of the 138 women had breast cancer. Another 34 relatives with breast cancer were identified in the families of the included women, of whom 11 were obligate MEN1 carriers, 14 had no MEN1 mutation, and 9 had an unknown MEN1 status. The median age at breast cancer diagnosis of women with MEN1 (n = 22) was 45 years (range, 30 to 80 years), in comparison with 57.5 years (range, 40 to 85 years) in female relatives without MEN1 (n = 14; P = 0.03) and 61.2 years in the Dutch reference population. Known endocrine risk factors and general risk factors were not different for women with and without breast cancer.
Conclusion:
The increased breast cancer risk in MEN1 carriers was not related to other known breast cancer risk factors or familial cancer history, and therefore breast cancer surveillance from the age of 40 years for all women with MEN1 is justifiable.
MEN1 is associated with an early-onset elevated breast cancer risk and is not related to other breast cancer risk factors. Early breast cancer surveillance is justified for all women with MEN1.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2016-3690</identifier><identifier>PMID: 28323962</identifier><language>eng</language><publisher>Washington, DC: Endocrine Society</publisher><subject>Adult ; Age ; Age of Onset ; Aged ; Aged, 80 and over ; Breast cancer ; Breast Neoplasms - diagnosis ; Breast Neoplasms - diagnostic imaging ; Breast Neoplasms - etiology ; Cancer screening ; Case-Control Studies ; Cross-Sectional Studies ; Early Detection of Cancer ; Female ; Genetic Predisposition to Disease ; Genetics ; Health risk assessment ; Health risks ; Humans ; Mammography ; Medical screening ; Middle Aged ; Multiple endocrine neoplasia ; Multiple Endocrine Neoplasia Type 1 - complications ; Mutation ; Netherlands ; Neuroendocrine tumors ; Risk Factors ; Surveillance</subject><ispartof>The journal of clinical endocrinology and metabolism, 2017-06, Vol.102 (6), p.2083-2090</ispartof><rights>Copyright © 2017 Endocrine Society 2017</rights><rights>Copyright © Oxford University Press 2015</rights><rights>Copyright © 2017 Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5006-806233f518d73e102c36ed09868d30f1863a6781f13ca10cd238fc940f0ad5b73</citedby><cites>FETCH-LOGICAL-c5006-806233f518d73e102c36ed09868d30f1863a6781f13ca10cd238fc940f0ad5b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1970003437?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,21367,27901,27902,33721,33722,43781</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28323962$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Leeuwaarde, Rachel S.</creatorcontrib><creatorcontrib>Dreijerink, Koen M.</creatorcontrib><creatorcontrib>Ausems, Margreet G.</creatorcontrib><creatorcontrib>Beijers, Hanneke J.</creatorcontrib><creatorcontrib>Dekkers, Olaf M.</creatorcontrib><creatorcontrib>de Herder, Wouter W.</creatorcontrib><creatorcontrib>van der Horst-Schrivers, Anouk N.</creatorcontrib><creatorcontrib>Drent, Madeleine L.</creatorcontrib><creatorcontrib>Bisschop, Peter H.</creatorcontrib><creatorcontrib>Havekes, Bas</creatorcontrib><creatorcontrib>Peeters, Petra H. M.</creatorcontrib><creatorcontrib>Pijnappel, Ruud M.</creatorcontrib><creatorcontrib>Vriens, Menno R.</creatorcontrib><creatorcontrib>Valk, Gerlof D.</creatorcontrib><title>MEN1-Dependent Breast Cancer: Indication for Early Screening? Results From the Dutch MEN1 Study Group</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Abstract
Objective:
Multiple endocrine neoplasia type 1 (MEN1) is associated with an early-onset elevated breast cancer risk. This finding potentially has implications for breast cancer screening for women with MEN1, and therefore it is necessary to assess whether other risk factors are involved to identify those at greatest risk.
Design:
A cross-sectional case control study was performed using the Dutch MEN1 cohort, including >90% of the adult Dutch MEN1 population. All women with a confirmed MEN1 mutation received a questionnaire regarding cancer family history and breast cancer–related endocrine and general cancer risk factors.
Results:
A total of 138 of 165 (84%) eligible women with MEN1 completed the questionnaire. Eleven of the 138 women had breast cancer. Another 34 relatives with breast cancer were identified in the families of the included women, of whom 11 were obligate MEN1 carriers, 14 had no MEN1 mutation, and 9 had an unknown MEN1 status. The median age at breast cancer diagnosis of women with MEN1 (n = 22) was 45 years (range, 30 to 80 years), in comparison with 57.5 years (range, 40 to 85 years) in female relatives without MEN1 (n = 14; P = 0.03) and 61.2 years in the Dutch reference population. Known endocrine risk factors and general risk factors were not different for women with and without breast cancer.
Conclusion:
The increased breast cancer risk in MEN1 carriers was not related to other known breast cancer risk factors or familial cancer history, and therefore breast cancer surveillance from the age of 40 years for all women with MEN1 is justifiable.
MEN1 is associated with an early-onset elevated breast cancer risk and is not related to other breast cancer risk factors. Early breast cancer surveillance is justified for all women with MEN1.</description><subject>Adult</subject><subject>Age</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Breast Neoplasms - etiology</subject><subject>Cancer screening</subject><subject>Case-Control Studies</subject><subject>Cross-Sectional Studies</subject><subject>Early Detection of Cancer</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetics</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Humans</subject><subject>Mammography</subject><subject>Medical screening</subject><subject>Middle Aged</subject><subject>Multiple endocrine neoplasia</subject><subject>Multiple Endocrine Neoplasia Type 1 - complications</subject><subject>Mutation</subject><subject>Netherlands</subject><subject>Neuroendocrine tumors</subject><subject>Risk Factors</subject><subject>Surveillance</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1ksFrFDEUh4Modq3ePEvAgx6c-pLMZDK9iG63tVAVrIK3kCZv3FlnkzXJUPa_N-NWD4KnEPjeL7_3EUKeMjhhnMHrjT3hwGQlZAf3yIJ1dVO1rGvvkwUAZ1XX8m9H5FFKGwBW1414SI64Elx0ki8Iflh9ZNUZ7tA79Jm-i2hSpkvjLcZTeundYE0egqd9iHRl4rin1zYi-sF_f0M_Y5rGnOh5DFua10jPpmzXdA6l13lye3oRw7R7TB70Zkz45O48Jl_PV1-W76urTxeXy7dXlW0AZKVAciH6hinXCmTArZDooFNSOQE9U1IY2SrWM2ENA-u4UL3taujBuOamFcfk5SF3F8PPCVPW2yFZHEfjMUxJM6UAVN00XUGf_4NuwhR9aaeLPAAQtZgDXx0oG0NKEXu9i8PWxL1moGf9emP1rF_P-gv-7C50utmi-wv_8V2A-gDchjFjTD_G6RajXqMZ81qXV6EuC1YlsQVZbtVcRJaxF4ex4vJ_DX5_APELCTmYHQ</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>van Leeuwaarde, Rachel S.</creator><creator>Dreijerink, Koen M.</creator><creator>Ausems, Margreet G.</creator><creator>Beijers, Hanneke J.</creator><creator>Dekkers, Olaf M.</creator><creator>de Herder, Wouter W.</creator><creator>van der Horst-Schrivers, Anouk N.</creator><creator>Drent, Madeleine L.</creator><creator>Bisschop, Peter H.</creator><creator>Havekes, Bas</creator><creator>Peeters, Petra H. M.</creator><creator>Pijnappel, Ruud M.</creator><creator>Vriens, Menno R.</creator><creator>Valk, Gerlof D.</creator><general>Endocrine Society</general><general>Copyright Oxford University Press</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201706</creationdate><title>MEN1-Dependent Breast Cancer: Indication for Early Screening? Results From the Dutch MEN1 Study Group</title><author>van Leeuwaarde, Rachel S. ; Dreijerink, Koen M. ; Ausems, Margreet G. ; Beijers, Hanneke J. ; Dekkers, Olaf M. ; de Herder, Wouter W. ; van der Horst-Schrivers, Anouk N. ; Drent, Madeleine L. ; Bisschop, Peter H. ; Havekes, Bas ; Peeters, Petra H. M. ; Pijnappel, Ruud M. ; Vriens, Menno R. ; Valk, Gerlof D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5006-806233f518d73e102c36ed09868d30f1863a6781f13ca10cd238fc940f0ad5b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Age</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Breast Neoplasms - diagnostic imaging</topic><topic>Breast Neoplasms - etiology</topic><topic>Cancer screening</topic><topic>Case-Control Studies</topic><topic>Cross-Sectional Studies</topic><topic>Early Detection of Cancer</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetics</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Humans</topic><topic>Mammography</topic><topic>Medical screening</topic><topic>Middle Aged</topic><topic>Multiple endocrine neoplasia</topic><topic>Multiple Endocrine Neoplasia Type 1 - complications</topic><topic>Mutation</topic><topic>Netherlands</topic><topic>Neuroendocrine tumors</topic><topic>Risk Factors</topic><topic>Surveillance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Leeuwaarde, Rachel S.</creatorcontrib><creatorcontrib>Dreijerink, Koen M.</creatorcontrib><creatorcontrib>Ausems, Margreet G.</creatorcontrib><creatorcontrib>Beijers, Hanneke J.</creatorcontrib><creatorcontrib>Dekkers, Olaf M.</creatorcontrib><creatorcontrib>de Herder, Wouter W.</creatorcontrib><creatorcontrib>van der Horst-Schrivers, Anouk N.</creatorcontrib><creatorcontrib>Drent, Madeleine L.</creatorcontrib><creatorcontrib>Bisschop, Peter H.</creatorcontrib><creatorcontrib>Havekes, Bas</creatorcontrib><creatorcontrib>Peeters, Petra H. M.</creatorcontrib><creatorcontrib>Pijnappel, Ruud M.</creatorcontrib><creatorcontrib>Vriens, Menno R.</creatorcontrib><creatorcontrib>Valk, Gerlof D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Leeuwaarde, Rachel S.</au><au>Dreijerink, Koen M.</au><au>Ausems, Margreet G.</au><au>Beijers, Hanneke J.</au><au>Dekkers, Olaf M.</au><au>de Herder, Wouter W.</au><au>van der Horst-Schrivers, Anouk N.</au><au>Drent, Madeleine L.</au><au>Bisschop, Peter H.</au><au>Havekes, Bas</au><au>Peeters, Petra H. M.</au><au>Pijnappel, Ruud M.</au><au>Vriens, Menno R.</au><au>Valk, Gerlof D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MEN1-Dependent Breast Cancer: Indication for Early Screening? Results From the Dutch MEN1 Study Group</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2017-06</date><risdate>2017</risdate><volume>102</volume><issue>6</issue><spage>2083</spage><epage>2090</epage><pages>2083-2090</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><abstract>Abstract
Objective:
Multiple endocrine neoplasia type 1 (MEN1) is associated with an early-onset elevated breast cancer risk. This finding potentially has implications for breast cancer screening for women with MEN1, and therefore it is necessary to assess whether other risk factors are involved to identify those at greatest risk.
Design:
A cross-sectional case control study was performed using the Dutch MEN1 cohort, including >90% of the adult Dutch MEN1 population. All women with a confirmed MEN1 mutation received a questionnaire regarding cancer family history and breast cancer–related endocrine and general cancer risk factors.
Results:
A total of 138 of 165 (84%) eligible women with MEN1 completed the questionnaire. Eleven of the 138 women had breast cancer. Another 34 relatives with breast cancer were identified in the families of the included women, of whom 11 were obligate MEN1 carriers, 14 had no MEN1 mutation, and 9 had an unknown MEN1 status. The median age at breast cancer diagnosis of women with MEN1 (n = 22) was 45 years (range, 30 to 80 years), in comparison with 57.5 years (range, 40 to 85 years) in female relatives without MEN1 (n = 14; P = 0.03) and 61.2 years in the Dutch reference population. Known endocrine risk factors and general risk factors were not different for women with and without breast cancer.
Conclusion:
The increased breast cancer risk in MEN1 carriers was not related to other known breast cancer risk factors or familial cancer history, and therefore breast cancer surveillance from the age of 40 years for all women with MEN1 is justifiable.
MEN1 is associated with an early-onset elevated breast cancer risk and is not related to other breast cancer risk factors. Early breast cancer surveillance is justified for all women with MEN1.</abstract><cop>Washington, DC</cop><pub>Endocrine Society</pub><pmid>28323962</pmid><doi>10.1210/jc.2016-3690</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The journal of clinical endocrinology and metabolism, 2017-06, Vol.102 (6), p.2083-2090 |
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| source | MEDLINE; Oxford University Press Journals Current; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Journals@Ovid Complete; ProQuest Central |
| subjects | Adult Age Age of Onset Aged Aged, 80 and over Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - diagnostic imaging Breast Neoplasms - etiology Cancer screening Case-Control Studies Cross-Sectional Studies Early Detection of Cancer Female Genetic Predisposition to Disease Genetics Health risk assessment Health risks Humans Mammography Medical screening Middle Aged Multiple endocrine neoplasia Multiple Endocrine Neoplasia Type 1 - complications Mutation Netherlands Neuroendocrine tumors Risk Factors Surveillance |
| title | MEN1-Dependent Breast Cancer: Indication for Early Screening? Results From the Dutch MEN1 Study Group |
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