Recent updates of carbapenem antibiotics

Carbapenems are among the most commonly used and the most efficient antibiotics since they are relatively resistant to hydrolysis by most β-lactamases, they target penicillin-binding proteins, and generally have broad-spectrum antibacterial effect. In this review, we described the initial discovery and development of carbapenems, chemical characteristics, in vitro/in vivo activities, resistance studies, and clinical investigations for traditional carbapenem antibiotics in the market; imipenem-cilastatin, meropenem, ertapenem, doripenem, biapenem, panipenem/betamipron in addition to newer carbapenems such as razupenem, tebipenem, tomopenem, and sanfetrinem. We focused on the literature published from 2010 to 2016. [Display omitted] •The recent updates of carbapenems reported from 2010 to 2016 have been reviewed.•The biological effects of the clinically-used carbapenems have been reviewed.•The bacterial resistance that threats their antibacterial effects has been highlighted.•Their chemical characteristics have been explained.