Discovery of Potent Antiallodynic Agents for Neuropathic Pain Targeting P2X3 Receptors

Antagonism of the P2X3 receptor is one of the potential therapeutic strategies for the management of neuropathic pain because P2X3 receptors are predominantly localized on small to medium diameter C- and Aδ-fiber primary afferent neurons, which are related to the pain-sensing system. In this study,...

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Veröffentlicht in:	ACS chemical neuroscience 2017-07, Vol.8 (7), p.1465-1478
Hauptverfasser:	Jung, Young-Hwan, Kim, Yeo Ok, Lin, Hai, Cho, Joong-Heui, Park, Jin-Hee, Lee, So-Deok, Bae, Jinsu, Kang, Koon Mook, Kim, Yoon-Gyoon, Pae, Ae Nim, Ko, Hyojin, Park, Chul-Seung, Yoon, Myung Ha, Kim, Yong-Chul
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Non-Narcotic - chemical synthesis Analgesics, Non-Narcotic - chemistry Analgesics, Non-Narcotic - pharmacokinetics Analgesics, Non-Narcotic - pharmacology Animals Antineoplastic Agents Brain - drug effects Brain - metabolism Disease Models, Animal HEK293 Cells Humans Ligation Male Mice Molecular Structure Neuralgia - drug therapy Neuralgia - metabolism Oocytes Patch-Clamp Techniques Permeability Purinergic P2X Receptor Antagonists - chemical synthesis Purinergic P2X Receptor Antagonists - chemistry Purinergic P2X Receptor Antagonists - pharmacokinetics Purinergic P2X Receptor Antagonists - pharmacology Pyridines - chemical synthesis Pyridines - chemistry Pyridines - pharmacokinetics Pyridines - pharmacology Rats Receptors, Purinergic P2X3 - metabolism Spinal Nerves Structure-Activity Relationship Xenopus
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