Novel phage-piezoelectric sensor for rapid drug susceptibility testing of Mycobacterium tuberculosis
Novel phage-piezoelectric sensor was constructed for rapid drug susceptibility testing based on the proposed method of phage amplified multichannel series piezoelectric quartz crystal sensor (PA-MSPQC) for the detection of Mycobacterium tuberculosis and criterion of resistant strains by CLSI. Under...
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| Veröffentlicht in: | Sensors and actuators. B, Chemical Chemical, 2014-03, Vol.193, p.715-722 |
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| container_title | Sensors and actuators. B, Chemical |
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| creator | Mi, Xianwen He, Fengjiao Xiang, Meiyu Lian, Yan Yi, Songlin |
| description | Novel phage-piezoelectric sensor was constructed for rapid drug susceptibility testing based on the proposed method of phage amplified multichannel series piezoelectric quartz crystal sensor (PA-MSPQC) for the detection of Mycobacterium tuberculosis and criterion of resistant strains by CLSI. Under the condition of anti-TB drugs, the resistant M. tuberculosis survived, but the sensitive strains can be killed. According to the criterion of resistant strains by CLSI, the 105cfu of strains with frequency shift less than 121Hz were resistant to rifampin, isoniazid and ethambutol, 92Hz to streptomycin. The sensitivity and specificity of 557 strains drug susceptibility test by proposed methods are 91% and 93%, respectively, compared with the mycobacteria growth indicator tube (MGIT) method. But the turnaround time of proposed method is no more than 35h, far less than that of MGIT 960 methods. It will find application in clinical test. |
| doi_str_mv | 10.1016/j.snb.2013.11.062 |
| format | Article |
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Under the condition of anti-TB drugs, the resistant M. tuberculosis survived, but the sensitive strains can be killed. According to the criterion of resistant strains by CLSI, the 105cfu of strains with frequency shift less than 121Hz were resistant to rifampin, isoniazid and ethambutol, 92Hz to streptomycin. The sensitivity and specificity of 557 strains drug susceptibility test by proposed methods are 91% and 93%, respectively, compared with the mycobacteria growth indicator tube (MGIT) method. But the turnaround time of proposed method is no more than 35h, far less than that of MGIT 960 methods. 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It will find application in clinical test.</description><subject>Actuators</subject><subject>Criteria</subject><subject>Drug susceptibility testing</subject><subject>Drugs</subject><subject>Mycobacterium smegmatis</subject><subject>Mycobacterium tuberculosis</subject><subject>Phage D29</subject><subject>Piezoelectricity</subject><subject>Quartz crystals</subject><subject>Sensors</subject><subject>Test procedures</subject><subject>Tuberculosis</subject><issn>0925-4005</issn><issn>1873-3077</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqNkE1r3DAQhkVpodtNf0BuOvZiZ0ayZZueQmiTQD4u6VnI0nirxWu5kh3Y_voobM4hA8PMwLzDOw9j5wglAqqLfZmmvhSAskQsQYlPbINtIwsJTfOZbaATdVEB1F_Zt5T2AFBJBRvmHsIzjXz-a3ZUzJ7-BxrJLtFbnmhKIfIhZzSzd9zFdcfTmizNi-_96JcjXygtftrxMPD7ow29sQtFvx74svYU7TqG5NMZ-zKYMdH3t7plf37_erq6Ke4er2-vLu8KK5Vcsr2u78DIihpHlXMoW1eLVtVdKy3kOXddpRoEIRujhsq2pgEShEbUVpHcsh-nu3MM_9bsTB98djuOZqKwJo1tCyAbaMUHVpUUiDLHluFp1caQUqRBz9EfTDxqBP0KX-91hq9f4WtEneFnzc-ThvK7z56iTtbTZMn5mPFqF_w76hfarY2_</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>Mi, Xianwen</creator><creator>He, Fengjiao</creator><creator>Xiang, Meiyu</creator><creator>Lian, Yan</creator><creator>Yi, Songlin</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7SP</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20140301</creationdate><title>Novel phage-piezoelectric sensor for rapid drug susceptibility testing of Mycobacterium tuberculosis</title><author>Mi, Xianwen ; He, Fengjiao ; Xiang, Meiyu ; Lian, Yan ; Yi, Songlin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-409b90a34e7de4dd138d52865983c0dd1659946710237a6f4c8a70e2e1a25c6e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Actuators</topic><topic>Criteria</topic><topic>Drug susceptibility testing</topic><topic>Drugs</topic><topic>Mycobacterium smegmatis</topic><topic>Mycobacterium tuberculosis</topic><topic>Phage D29</topic><topic>Piezoelectricity</topic><topic>Quartz crystals</topic><topic>Sensors</topic><topic>Test procedures</topic><topic>Tuberculosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mi, Xianwen</creatorcontrib><creatorcontrib>He, Fengjiao</creatorcontrib><creatorcontrib>Xiang, Meiyu</creatorcontrib><creatorcontrib>Lian, Yan</creatorcontrib><creatorcontrib>Yi, Songlin</creatorcontrib><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Sensors and actuators. B, Chemical</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mi, Xianwen</au><au>He, Fengjiao</au><au>Xiang, Meiyu</au><au>Lian, Yan</au><au>Yi, Songlin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel phage-piezoelectric sensor for rapid drug susceptibility testing of Mycobacterium tuberculosis</atitle><jtitle>Sensors and actuators. B, Chemical</jtitle><date>2014-03-01</date><risdate>2014</risdate><volume>193</volume><spage>715</spage><epage>722</epage><pages>715-722</pages><issn>0925-4005</issn><eissn>1873-3077</eissn><abstract>Novel phage-piezoelectric sensor was constructed for rapid drug susceptibility testing based on the proposed method of phage amplified multichannel series piezoelectric quartz crystal sensor (PA-MSPQC) for the detection of Mycobacterium tuberculosis and criterion of resistant strains by CLSI. 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| ispartof | Sensors and actuators. B, Chemical, 2014-03, Vol.193, p.715-722 |
| issn | 0925-4005 1873-3077 |
| language | eng |
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| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Actuators Criteria Drug susceptibility testing Drugs Mycobacterium smegmatis Mycobacterium tuberculosis Phage D29 Piezoelectricity Quartz crystals Sensors Test procedures Tuberculosis |
| title | Novel phage-piezoelectric sensor for rapid drug susceptibility testing of Mycobacterium tuberculosis |
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