Effect of Manganese Exposure on MPTP Neurotoxicities

We used a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice model to evaluate whether manganese (Mn) exposure can affect MPTP-induced neurotoxicity. We randomly assigned adult male C57BL/6 mice ( n=5–7 per group) the following treatments: SO, Mn(−) × MPTP(−); MO, Mn(+) × MPTP(−); SM,...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2003-08, Vol.24 (4), p.657-665
Hauptverfasser:	Baek, Sun Yong, Lee, Myong-Jong, Jung, Hyun-Sil, Kim, Hyun-Ju, Lee, Choong-Ryeol, Yoo, Cheolin, Lee, Ji Ho, Lee, Hun, Yoon, Chung Sik, Kim, Young Hoon, Park, Jungsun, Kim, Jae-Woo, Jeon, Beom S, Kim, Yangho
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Corpus Striatum - drug effects Corpus Striatum - metabolism Corpus Striatum - pathology Dopamine Drug Synergism Globus Pallidus - drug effects Globus Pallidus - metabolism Globus Pallidus - pathology Male Manganese Manganese - blood Manganese - pharmacology Medical sciences Metals and various inorganic compounds Mice Mice, Inbred C57BL MPTP MPTP Poisoning - chemically induced MPTP Poisoning - metabolism MPTP Poisoning - pathology Neurotoxicity Parkinson disease Presynaptic Terminals - drug effects Presynaptic Terminals - metabolism Presynaptic Terminals - pathology Toxicology
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