High-resolution sub-cellular imaging by correlative NanoSIMS and electron microscopy of amiodarone internalisation by lung macrophages as evidence for drug-induced phospholipidosis
Correlative NanoSIMS and EM imaging of amiodarone-treated macrophages shows the internalisation of the drug at a sub-cellular level and reveals its accumulation within the lysosomes, providing direct evidence for amiodarone-induced phospholipidosis. Chemical fixation using tannic acid effectively se...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2017, Vol.53 (9), p.1506-1509 |
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| container_end_page | 1509 |
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| container_issue | 9 |
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| container_title | Chemical communications (Cambridge, England) |
| container_volume | 53 |
| creator | Jiang, Haibo Passarelli, Melissa K Munro, Peter M G Kilburn, Matt R West, Andrew Dollery, Colin T Gilmore, Ian S Rakowska, Paulina D |
| description | Correlative NanoSIMS and EM imaging of amiodarone-treated macrophages shows the internalisation of the drug at a sub-cellular level and reveals its accumulation within the lysosomes, providing direct evidence for amiodarone-induced phospholipidosis. Chemical fixation using tannic acid effectively seals cellular membranes aiding intracellular retention of diffusible drugs. |
| doi_str_mv | 10.1039/c6cc08549k |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Chemical communications (Cambridge, England), 2017, Vol.53 (9), p.1506-1509 |
| issn | 1359-7345 1364-548X |
| language | eng |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Correlation Drugs Image resolution Imaging Lysosomes Macrophages Nanostructure Tannic acid |
| title | High-resolution sub-cellular imaging by correlative NanoSIMS and electron microscopy of amiodarone internalisation by lung macrophages as evidence for drug-induced phospholipidosis |
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