Fast Single-Cell Patterning for Study of Drug-Induced Phenotypic Alterations of HeLa Cells Using Time-of-Flight Secondary Ion Mass Spectrometry

A facile single-cell patterning (ScP) method was developed and integrated with time-of-flight secondary ion mass spectrometry (TOF-SIMS) for the study of drug-induced cellular phenotypic alterations. Micropatterned poly­(dimethylsiloxane) (PDMS) stencil film and centrifugation-assisted cell trapping...

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Veröffentlicht in:	Analytical chemistry (Washington) 2016-12, Vol.88 (24), p.12196-12203
Hauptverfasser:	Huang, Lu, Chen, Yin, Weng, Lu-Tao, Leung, Mark, Xing, Xiaoxing, Fan, Zhiyong, Wu, Hongkai
Format:	Artikel
Sprache:	eng
Schlagworte:	Alterations Analytical chemistry Apoptosis Cells Genotype & phenotype Mass spectrometry Patterning Secondary ion mass spectrometry Silicone resins Trapping
Online-Zugang:	Volltext
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