Fractionating power and outlet stream polydispersity in asymmetrical flow field-flow fractionation. Part II: programmed operation
Asymmetrical flow field-flow fractionation (As-FlFFF) is a widely used technique for analyzing polydisperse nanoparticle and macromolecular samples. The programmed decay of cross flow rate is often employed. The interdependence of the cross flow rate through the membrane and the fluid flow along the...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2017, Vol.409 (1), p.317-334 |
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| description | Asymmetrical flow field-flow fractionation (As-FlFFF) is a widely used technique for analyzing polydisperse nanoparticle and macromolecular samples. The programmed decay of cross flow rate is often employed. The interdependence of the cross flow rate through the membrane and the fluid flow along the channel length complicates the prediction of elution time and fractionating power. The theory for their calculation is presented. It is also confirmed for examples of exponential decay of cross flow rate with constant channel outlet flow rate that the residual sample polydispersity at the channel outlet is quite well approximated by the reciprocal of four times the fractionating power. Residual polydispersity is of importance when online MALS or DLS detection are used to extract quantitative information on particle size or molecular weight. The theory presented here provides a firm basis for the optimization of programmed flow conditions in As-FlFFF.
Graphical abstract
Channel outlet polydispersity remains significant following fractionation by As-FlFFF under conditions of programmed decay of cross flow rate |
| doi_str_mv | 10.1007/s00216-016-0007-x |
| format | Article |
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Graphical abstract
Channel outlet polydispersity remains significant following fractionation by As-FlFFF under conditions of programmed decay of cross flow rate</description><identifier>ISSN: 1618-2642</identifier><identifier>EISSN: 1618-2650</identifier><identifier>DOI: 10.1007/s00216-016-0007-x</identifier><identifier>PMID: 27838749</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Analysis ; Analytical Chemistry ; Asymmetry ; Biochemistry ; Channels ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Cross flow ; Decay ; Distillation ; Flow rates ; Flow velocity ; Fluid flow ; Food Science ; Fractionation ; Laboratory Medicine ; Mathematical analysis ; Methods ; Molecular weight ; Monitoring/Environmental Analysis ; nanoparticles ; Outlets ; Particle size ; Polydispersity ; prediction ; Research Paper ; Retention ; Separation (Technology) ; Standard deviation ; streams</subject><ispartof>Analytical and bioanalytical chemistry, 2017, Vol.409 (1), p.317-334</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><rights>COPYRIGHT 2017 Springer</rights><rights>Springer-Verlag Berlin Heidelberg 2016.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-1c1a61be5b9058287c4799b584919f015fb1236ae22a56d597263676f19e5c673</citedby><cites>FETCH-LOGICAL-c547t-1c1a61be5b9058287c4799b584919f015fb1236ae22a56d597263676f19e5c673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00216-016-0007-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00216-016-0007-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27838749$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Williams, P. Stephen</creatorcontrib><title>Fractionating power and outlet stream polydispersity in asymmetrical flow field-flow fractionation. Part II: programmed operation</title><title>Analytical and bioanalytical chemistry</title><addtitle>Anal Bioanal Chem</addtitle><addtitle>Anal Bioanal Chem</addtitle><description>Asymmetrical flow field-flow fractionation (As-FlFFF) is a widely used technique for analyzing polydisperse nanoparticle and macromolecular samples. The programmed decay of cross flow rate is often employed. The interdependence of the cross flow rate through the membrane and the fluid flow along the channel length complicates the prediction of elution time and fractionating power. The theory for their calculation is presented. It is also confirmed for examples of exponential decay of cross flow rate with constant channel outlet flow rate that the residual sample polydispersity at the channel outlet is quite well approximated by the reciprocal of four times the fractionating power. Residual polydispersity is of importance when online MALS or DLS detection are used to extract quantitative information on particle size or molecular weight. The theory presented here provides a firm basis for the optimization of programmed flow conditions in As-FlFFF.
Graphical abstract
Channel outlet polydispersity remains significant following fractionation by As-FlFFF under conditions of programmed decay of cross flow rate</description><subject>Analysis</subject><subject>Analytical Chemistry</subject><subject>Asymmetry</subject><subject>Biochemistry</subject><subject>Channels</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Cross flow</subject><subject>Decay</subject><subject>Distillation</subject><subject>Flow rates</subject><subject>Flow velocity</subject><subject>Fluid flow</subject><subject>Food Science</subject><subject>Fractionation</subject><subject>Laboratory Medicine</subject><subject>Mathematical analysis</subject><subject>Methods</subject><subject>Molecular weight</subject><subject>Monitoring/Environmental Analysis</subject><subject>nanoparticles</subject><subject>Outlets</subject><subject>Particle size</subject><subject>Polydispersity</subject><subject>prediction</subject><subject>Research Paper</subject><subject>Retention</subject><subject>Separation (Technology)</subject><subject>Standard deviation</subject><subject>streams</subject><issn>1618-2642</issn><issn>1618-2650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkk1v1DAQhiMEoqXwA7ggS1y4ZPE48Re3qqKwUiV6aM-RkzgrV4m92I7aPfLPmZC2ICREZVke28-8ej2eongLdAOUyo-JUgaipMvEfXn3rDgGAapkgtPnj3HNjopXKd1QClyBeFkcMakqJWt9XPw4j6bLLniTnd-Rfbi1kRjfkzDn0WaScrRmwvPx0Lu0tzG5fCDOE5MO02RzdJ0ZyTCGWzI4O_blGv4WDX5DLk3MZLv9RPYx7KLBPNRHrV_Xr4sXgxmTfXO_nhTX55-vzr6WF9--bM9OL8qO1zKX0IER0FreasoVU7KrpdYtV7UGPeDLhhZYJYxlzHDRcy2ZqIQUA2jLOyGrk-LDqosmvs825WZyqbPjaLwNc2oYlrDWUtPqvygohZWXUOknoFzXCiopnoBWGoCjKKLv_0Jvwhw9lmcRrCu1vB2pzUrtzGgb54eQse44eju5Lng7ODw_rSVHv1wtDmBN6GJIKdqh2Uc3mXhogDZLRzVrRzV0mcv-DnPe3VuZW_y3x4yHFkKArUDCK7-z8Q-v_1T9CSLs1ZY</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>Williams, P. Stephen</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>H8G</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>2017</creationdate><title>Fractionating power and outlet stream polydispersity in asymmetrical flow field-flow fractionation. Part II: programmed operation</title><author>Williams, P. Stephen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-1c1a61be5b9058287c4799b584919f015fb1236ae22a56d597263676f19e5c673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Analysis</topic><topic>Analytical Chemistry</topic><topic>Asymmetry</topic><topic>Biochemistry</topic><topic>Channels</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Cross flow</topic><topic>Decay</topic><topic>Distillation</topic><topic>Flow rates</topic><topic>Flow velocity</topic><topic>Fluid flow</topic><topic>Food Science</topic><topic>Fractionation</topic><topic>Laboratory Medicine</topic><topic>Mathematical analysis</topic><topic>Methods</topic><topic>Molecular weight</topic><topic>Monitoring/Environmental Analysis</topic><topic>nanoparticles</topic><topic>Outlets</topic><topic>Particle size</topic><topic>Polydispersity</topic><topic>prediction</topic><topic>Research Paper</topic><topic>Retention</topic><topic>Separation (Technology)</topic><topic>Standard deviation</topic><topic>streams</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Williams, P. 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Stephen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fractionating power and outlet stream polydispersity in asymmetrical flow field-flow fractionation. Part II: programmed operation</atitle><jtitle>Analytical and bioanalytical chemistry</jtitle><stitle>Anal Bioanal Chem</stitle><addtitle>Anal Bioanal Chem</addtitle><date>2017</date><risdate>2017</risdate><volume>409</volume><issue>1</issue><spage>317</spage><epage>334</epage><pages>317-334</pages><issn>1618-2642</issn><eissn>1618-2650</eissn><abstract>Asymmetrical flow field-flow fractionation (As-FlFFF) is a widely used technique for analyzing polydisperse nanoparticle and macromolecular samples. The programmed decay of cross flow rate is often employed. The interdependence of the cross flow rate through the membrane and the fluid flow along the channel length complicates the prediction of elution time and fractionating power. The theory for their calculation is presented. It is also confirmed for examples of exponential decay of cross flow rate with constant channel outlet flow rate that the residual sample polydispersity at the channel outlet is quite well approximated by the reciprocal of four times the fractionating power. Residual polydispersity is of importance when online MALS or DLS detection are used to extract quantitative information on particle size or molecular weight. The theory presented here provides a firm basis for the optimization of programmed flow conditions in As-FlFFF.
Graphical abstract
Channel outlet polydispersity remains significant following fractionation by As-FlFFF under conditions of programmed decay of cross flow rate</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27838749</pmid><doi>10.1007/s00216-016-0007-x</doi><tpages>18</tpages></addata></record> |
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| subjects | Analysis Analytical Chemistry Asymmetry Biochemistry Channels Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Cross flow Decay Distillation Flow rates Flow velocity Fluid flow Food Science Fractionation Laboratory Medicine Mathematical analysis Methods Molecular weight Monitoring/Environmental Analysis nanoparticles Outlets Particle size Polydispersity prediction Research Paper Retention Separation (Technology) Standard deviation streams |
| title | Fractionating power and outlet stream polydispersity in asymmetrical flow field-flow fractionation. Part II: programmed operation |
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