Solvent- and halide-free synthesis of pyridine-2-yl substituted ureas through facile C–H functionalization of pyridine N-oxides

A novel solvent- and halide-free atom-economical synthesis of practically useful pyridine-2-yl substituted ureas utilizes easily accessible or commercially available pyridine N-oxides (PyO) and dialkylcyanamides. The observed C-H functionalization of PyO is suitable for the good-to-high yielding syn...

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Veröffentlicht in:Green chemistry : an international journal and green chemistry resource : GC 2016-01, Vol.18 (24), p.6630-6636
Hauptverfasser: Rassadin, Valentin A, Zimin, Dmitry P, Raskil'dina, Gulnara Z, Ivanov, Alexander Yu, Boyarskiy, Vadim P, Zlotskii, Semen S, Kukushkin, Vadim Yu
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Sprache:eng
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