Carbon quantum dot-gold nanocluster nanosatellite for ratiometric fluorescence probe and imaging for hydrogen peroxide in living cells
[Display omitted] •Carbon quantum dot-gold nanocluster nanosatellite was synthesized.•High FRET efficiency between carbon quantum dots and gold nanoclusters was displayed.•A sensitive ratiometric fluorescence probe for H2O2 was proposed.•The response toward H2O2 of proposed nanosatellite probe was s...
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| Veröffentlicht in: | Sensors and actuators. B, Chemical Chemical, 2017-03, Vol.241, p.821-827 |
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| container_title | Sensors and actuators. B, Chemical |
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| creator | Li, Zenghe Guo, Song Yuan, Zhiqin Lu, Chao |
| description | [Display omitted]
•Carbon quantum dot-gold nanocluster nanosatellite was synthesized.•High FRET efficiency between carbon quantum dots and gold nanoclusters was displayed.•A sensitive ratiometric fluorescence probe for H2O2 was proposed.•The response toward H2O2 of proposed nanosatellite probe was selective.•The capability of the nanosatellite probe was validated by intracellular H2O2 imaging.
Developing probes for sensitive H2O2 detection is critical for understanding its related physiological and pathological processes. In this study, novel carbon quantum dot-gold nanocluster (CQD-AuNC) nanosatellite with high fluorescence energy transfer efficiency (∼40%) and dual-emission fluorescent properties have been exploited for fluorescence ratiometric sensing of H2O2. The sensing mechanism was based on the fact that H2O2 can quench the red emission of AuNCs. Under the optimal conditions, the CQD-AuNC nanosatellite probe was sensitive to H2O2 in the range from 5.0nM to 80nM with a limit of detection of 2.9nM. The practicality of the proposed CQD-AuNC nanosatellite probe was validated by imaging H2O2 in living cells. |
| doi_str_mv | 10.1016/j.snb.2016.10.134 |
| format | Article |
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•Carbon quantum dot-gold nanocluster nanosatellite was synthesized.•High FRET efficiency between carbon quantum dots and gold nanoclusters was displayed.•A sensitive ratiometric fluorescence probe for H2O2 was proposed.•The response toward H2O2 of proposed nanosatellite probe was selective.•The capability of the nanosatellite probe was validated by intracellular H2O2 imaging.
Developing probes for sensitive H2O2 detection is critical for understanding its related physiological and pathological processes. In this study, novel carbon quantum dot-gold nanocluster (CQD-AuNC) nanosatellite with high fluorescence energy transfer efficiency (∼40%) and dual-emission fluorescent properties have been exploited for fluorescence ratiometric sensing of H2O2. The sensing mechanism was based on the fact that H2O2 can quench the red emission of AuNCs. Under the optimal conditions, the CQD-AuNC nanosatellite probe was sensitive to H2O2 in the range from 5.0nM to 80nM with a limit of detection of 2.9nM. The practicality of the proposed CQD-AuNC nanosatellite probe was validated by imaging H2O2 in living cells.</description><identifier>ISSN: 0925-4005</identifier><identifier>EISSN: 1873-3077</identifier><identifier>DOI: 10.1016/j.snb.2016.10.134</identifier><language>eng</language><publisher>Lausanne: Elsevier B.V</publisher><subject>Actuators ; Carbon ; Carbon quantum dots ; Cells ; Cells (biology) ; Detection ; Emission ; Fluorescence ; Fluorescent indicators ; Gold ; Gold nanoclusters ; Hydrogen peroxide ; Imaging ; Nanoclusters ; Nanoparticles ; Nanosatellites ; Nanostructure ; Quantum dots ; Qunatum dots ; Ratiometric fluorescence</subject><ispartof>Sensors and actuators. B, Chemical, 2017-03, Vol.241, p.821-827</ispartof><rights>2016 Elsevier B.V.</rights><rights>Copyright Elsevier Science Ltd. Mar 31, 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c358t-d0b2dee17c0ec68143ed848066055226dc5b232ac901eca33edf3205b8da5bb3</citedby><cites>FETCH-LOGICAL-c358t-d0b2dee17c0ec68143ed848066055226dc5b232ac901eca33edf3205b8da5bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0925400516317622$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>Li, Zenghe</creatorcontrib><creatorcontrib>Guo, Song</creatorcontrib><creatorcontrib>Yuan, Zhiqin</creatorcontrib><creatorcontrib>Lu, Chao</creatorcontrib><title>Carbon quantum dot-gold nanocluster nanosatellite for ratiometric fluorescence probe and imaging for hydrogen peroxide in living cells</title><title>Sensors and actuators. B, Chemical</title><description>[Display omitted]
•Carbon quantum dot-gold nanocluster nanosatellite was synthesized.•High FRET efficiency between carbon quantum dots and gold nanoclusters was displayed.•A sensitive ratiometric fluorescence probe for H2O2 was proposed.•The response toward H2O2 of proposed nanosatellite probe was selective.•The capability of the nanosatellite probe was validated by intracellular H2O2 imaging.
Developing probes for sensitive H2O2 detection is critical for understanding its related physiological and pathological processes. In this study, novel carbon quantum dot-gold nanocluster (CQD-AuNC) nanosatellite with high fluorescence energy transfer efficiency (∼40%) and dual-emission fluorescent properties have been exploited for fluorescence ratiometric sensing of H2O2. The sensing mechanism was based on the fact that H2O2 can quench the red emission of AuNCs. Under the optimal conditions, the CQD-AuNC nanosatellite probe was sensitive to H2O2 in the range from 5.0nM to 80nM with a limit of detection of 2.9nM. The practicality of the proposed CQD-AuNC nanosatellite probe was validated by imaging H2O2 in living cells.</description><subject>Actuators</subject><subject>Carbon</subject><subject>Carbon quantum dots</subject><subject>Cells</subject><subject>Cells (biology)</subject><subject>Detection</subject><subject>Emission</subject><subject>Fluorescence</subject><subject>Fluorescent indicators</subject><subject>Gold</subject><subject>Gold nanoclusters</subject><subject>Hydrogen peroxide</subject><subject>Imaging</subject><subject>Nanoclusters</subject><subject>Nanoparticles</subject><subject>Nanosatellites</subject><subject>Nanostructure</subject><subject>Quantum dots</subject><subject>Qunatum dots</subject><subject>Ratiometric fluorescence</subject><issn>0925-4005</issn><issn>1873-3077</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kcFuGyEQhlGVSHXcPEBvSL30ss4Au2usnCKrSSNZ6sV3xMKsi7UGG1irfoE-d1m7px56YjTz_aN_-An5zGDBgLVP-0Xy3YKXcjG1RP2BzJhcikrAcnlHZrDiTVUDNB_JQ0p7AKhFCzPye61jFzw9jdrn8UBtyNUuDJZ67YMZxpQxXuukMw6Dy0j7EGnU2YUD5ugM7YcxREwGvUF6jKFDqr2l7qB3zu-u-M-LjWGHnh4xhl_OInWeDu48zU1Zmz6R-14PCR__vnOyff22XX-vNj_e3tcvm8qIRubKQsctIlsaQNNKVgu0spbQttA0nLfWNB0XXJsVMDRalHEvODSdtLrpOjEnX29ri83TiCmrg0uTAe0xjEkxKQEKz1lBv_yD7sMYfTGnOMhWioktFLtRJoaUIvbqGMvh8aIYqCkYtVclGDUFc22Jumiebxosh54dRpWMmz7PuogmKxvcf9R_AH8LmPU</recordid><startdate>20170331</startdate><enddate>20170331</enddate><creator>Li, Zenghe</creator><creator>Guo, Song</creator><creator>Yuan, Zhiqin</creator><creator>Lu, Chao</creator><general>Elsevier B.V</general><general>Elsevier Science Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20170331</creationdate><title>Carbon quantum dot-gold nanocluster nanosatellite for ratiometric fluorescence probe and imaging for hydrogen peroxide in living cells</title><author>Li, Zenghe ; Guo, Song ; Yuan, Zhiqin ; Lu, Chao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c358t-d0b2dee17c0ec68143ed848066055226dc5b232ac901eca33edf3205b8da5bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Actuators</topic><topic>Carbon</topic><topic>Carbon quantum dots</topic><topic>Cells</topic><topic>Cells (biology)</topic><topic>Detection</topic><topic>Emission</topic><topic>Fluorescence</topic><topic>Fluorescent indicators</topic><topic>Gold</topic><topic>Gold nanoclusters</topic><topic>Hydrogen peroxide</topic><topic>Imaging</topic><topic>Nanoclusters</topic><topic>Nanoparticles</topic><topic>Nanosatellites</topic><topic>Nanostructure</topic><topic>Quantum dots</topic><topic>Qunatum dots</topic><topic>Ratiometric fluorescence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Zenghe</creatorcontrib><creatorcontrib>Guo, Song</creatorcontrib><creatorcontrib>Yuan, Zhiqin</creatorcontrib><creatorcontrib>Lu, Chao</creatorcontrib><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Sensors and actuators. B, Chemical</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Zenghe</au><au>Guo, Song</au><au>Yuan, Zhiqin</au><au>Lu, Chao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carbon quantum dot-gold nanocluster nanosatellite for ratiometric fluorescence probe and imaging for hydrogen peroxide in living cells</atitle><jtitle>Sensors and actuators. B, Chemical</jtitle><date>2017-03-31</date><risdate>2017</risdate><volume>241</volume><spage>821</spage><epage>827</epage><pages>821-827</pages><issn>0925-4005</issn><eissn>1873-3077</eissn><abstract>[Display omitted]
•Carbon quantum dot-gold nanocluster nanosatellite was synthesized.•High FRET efficiency between carbon quantum dots and gold nanoclusters was displayed.•A sensitive ratiometric fluorescence probe for H2O2 was proposed.•The response toward H2O2 of proposed nanosatellite probe was selective.•The capability of the nanosatellite probe was validated by intracellular H2O2 imaging.
Developing probes for sensitive H2O2 detection is critical for understanding its related physiological and pathological processes. In this study, novel carbon quantum dot-gold nanocluster (CQD-AuNC) nanosatellite with high fluorescence energy transfer efficiency (∼40%) and dual-emission fluorescent properties have been exploited for fluorescence ratiometric sensing of H2O2. The sensing mechanism was based on the fact that H2O2 can quench the red emission of AuNCs. Under the optimal conditions, the CQD-AuNC nanosatellite probe was sensitive to H2O2 in the range from 5.0nM to 80nM with a limit of detection of 2.9nM. The practicality of the proposed CQD-AuNC nanosatellite probe was validated by imaging H2O2 in living cells.</abstract><cop>Lausanne</cop><pub>Elsevier B.V</pub><doi>10.1016/j.snb.2016.10.134</doi><tpages>7</tpages></addata></record> |
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| ispartof | Sensors and actuators. B, Chemical, 2017-03, Vol.241, p.821-827 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Actuators Carbon Carbon quantum dots Cells Cells (biology) Detection Emission Fluorescence Fluorescent indicators Gold Gold nanoclusters Hydrogen peroxide Imaging Nanoclusters Nanoparticles Nanosatellites Nanostructure Quantum dots Qunatum dots Ratiometric fluorescence |
| title | Carbon quantum dot-gold nanocluster nanosatellite for ratiometric fluorescence probe and imaging for hydrogen peroxide in living cells |
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