Selective modulation of cortical state during spatial attention
Neocortical activity is permeated with endogenously generated fluctuations, but how these dynamics affect goal-directed behavior remains a mystery. We found that ensemble neural activity in primate visual cortex spontaneously fluctuated between phases of vigorous (On) and faint (Off) spiking synchro...
Gespeichert in:
| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2016-12, Vol.354 (6316), p.1140-1144 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1144 |
|---|---|
| container_issue | 6316 |
| container_start_page | 1140 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 354 |
| creator | Engel, Tatiana A. Steinmetz, Nicholas A. Gieselmann, Marc A. Thiele, Alexander Moore, Tirin Boahen, Kwabena |
| description | Neocortical activity is permeated with endogenously generated fluctuations, but how these dynamics affect goal-directed behavior remains a mystery. We found that ensemble neural activity in primate visual cortex spontaneously fluctuated between phases of vigorous (On) and faint (Off) spiking synchronously across cortical layers. These On-Off dynamics, reflecting global changes in cortical state, were also modulated at a local scale during selective attention. Moreover, the momentary phase of local ensemble activity predicted behavioral performance. Our results show that cortical state is controlled locally within a cortical map according to cognitive demands and reveal the impact of these local changes in cortical state on goal-directed behavior. |
| doi_str_mv | 10.1126/science.aag1420 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1880014762</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>44711117</jstor_id><sourcerecordid>44711117</sourcerecordid><originalsourceid>FETCH-LOGICAL-c487t-8599717efce3aaf77daf7a6457c0cad8aaaaf74afbd082909f55facca3d1e32f3</originalsourceid><addsrcrecordid>eNqN0UtLxDAQAOAgirs-zp6UghcvXSdN2iQnkcUXLHhQz2VME-nSbdYkFfz3puy6B0_mkMDMl4GZIeSMwozSoroOujW9NjPED8oL2CNTCqrMVQFsn0wBWJVLEOWEHIWwBEg5xQ7JpBCKcVGxKbl5MZ3Rsf0y2co1Q4exdX3mbKadj63GLgsRo8mawbf9RxbWCaQgxmj6kZ6QA4tdMKfb95i83d-9zh_zxfPD0_x2kWsuRcxlqZSgwlhtGKIVokkXVrwUGjQ2EnGMcrTvDchCgbJlaVFrZA01rLDsmFxt6q69-xxMiPWqDdp0HfbGDaGmUgLQ1FPxD8qFVEDlSC__0KUbfJ8aGVVZCC6hSup6o7R3IXhj67VvV-i_awr1uIZ6u4Z6u4b042Jbd3hfmWbnf-eewPkGLEN0fpfnXNB0BPsBsXaPlw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1845274806</pqid></control><display><type>article</type><title>Selective modulation of cortical state during spatial attention</title><source>American Association for the Advancement of Science</source><source>Jstor Complete Legacy</source><source>MEDLINE</source><creator>Engel, Tatiana A. ; Steinmetz, Nicholas A. ; Gieselmann, Marc A. ; Thiele, Alexander ; Moore, Tirin ; Boahen, Kwabena</creator><creatorcontrib>Engel, Tatiana A. ; Steinmetz, Nicholas A. ; Gieselmann, Marc A. ; Thiele, Alexander ; Moore, Tirin ; Boahen, Kwabena</creatorcontrib><description>Neocortical activity is permeated with endogenously generated fluctuations, but how these dynamics affect goal-directed behavior remains a mystery. We found that ensemble neural activity in primate visual cortex spontaneously fluctuated between phases of vigorous (On) and faint (Off) spiking synchronously across cortical layers. These On-Off dynamics, reflecting global changes in cortical state, were also modulated at a local scale during selective attention. Moreover, the momentary phase of local ensemble activity predicted behavioral performance. Our results show that cortical state is controlled locally within a cortical map according to cognitive demands and reveal the impact of these local changes in cortical state on goal-directed behavior.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.aag1420</identifier><identifier>PMID: 27934763</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Animal behavior ; Animal cognition ; Animals ; Attention ; Attention - physiology ; Brain ; Brain Mapping ; Correlation ; Dynamics ; Electrodes ; Fluctuation ; Goals ; Macaca mulatta ; Male ; Modulation ; Monkeys & apes ; Nerve Net - physiology ; Neurobiology ; Phases ; Spiking ; Visual Cortex - physiology</subject><ispartof>Science (American Association for the Advancement of Science), 2016-12, Vol.354 (6316), p.1140-1144</ispartof><rights>Copyright © 2016 American Association for the Advancement of Science</rights><rights>Copyright © 2016, American Association for the Advancement of Science.</rights><rights>Copyright © 2016, American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-8599717efce3aaf77daf7a6457c0cad8aaaaf74afbd082909f55facca3d1e32f3</citedby><cites>FETCH-LOGICAL-c487t-8599717efce3aaf77daf7a6457c0cad8aaaaf74afbd082909f55facca3d1e32f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/44711117$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/44711117$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27934763$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Engel, Tatiana A.</creatorcontrib><creatorcontrib>Steinmetz, Nicholas A.</creatorcontrib><creatorcontrib>Gieselmann, Marc A.</creatorcontrib><creatorcontrib>Thiele, Alexander</creatorcontrib><creatorcontrib>Moore, Tirin</creatorcontrib><creatorcontrib>Boahen, Kwabena</creatorcontrib><title>Selective modulation of cortical state during spatial attention</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Neocortical activity is permeated with endogenously generated fluctuations, but how these dynamics affect goal-directed behavior remains a mystery. We found that ensemble neural activity in primate visual cortex spontaneously fluctuated between phases of vigorous (On) and faint (Off) spiking synchronously across cortical layers. These On-Off dynamics, reflecting global changes in cortical state, were also modulated at a local scale during selective attention. Moreover, the momentary phase of local ensemble activity predicted behavioral performance. Our results show that cortical state is controlled locally within a cortical map according to cognitive demands and reveal the impact of these local changes in cortical state on goal-directed behavior.</description><subject>Animal behavior</subject><subject>Animal cognition</subject><subject>Animals</subject><subject>Attention</subject><subject>Attention - physiology</subject><subject>Brain</subject><subject>Brain Mapping</subject><subject>Correlation</subject><subject>Dynamics</subject><subject>Electrodes</subject><subject>Fluctuation</subject><subject>Goals</subject><subject>Macaca mulatta</subject><subject>Male</subject><subject>Modulation</subject><subject>Monkeys & apes</subject><subject>Nerve Net - physiology</subject><subject>Neurobiology</subject><subject>Phases</subject><subject>Spiking</subject><subject>Visual Cortex - physiology</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0UtLxDAQAOAgirs-zp6UghcvXSdN2iQnkcUXLHhQz2VME-nSbdYkFfz3puy6B0_mkMDMl4GZIeSMwozSoroOujW9NjPED8oL2CNTCqrMVQFsn0wBWJVLEOWEHIWwBEg5xQ7JpBCKcVGxKbl5MZ3Rsf0y2co1Q4exdX3mbKadj63GLgsRo8mawbf9RxbWCaQgxmj6kZ6QA4tdMKfb95i83d-9zh_zxfPD0_x2kWsuRcxlqZSgwlhtGKIVokkXVrwUGjQ2EnGMcrTvDchCgbJlaVFrZA01rLDsmFxt6q69-xxMiPWqDdp0HfbGDaGmUgLQ1FPxD8qFVEDlSC__0KUbfJ8aGVVZCC6hSup6o7R3IXhj67VvV-i_awr1uIZ6u4Z6u4b042Jbd3hfmWbnf-eewPkGLEN0fpfnXNB0BPsBsXaPlw</recordid><startdate>20161202</startdate><enddate>20161202</enddate><creator>Engel, Tatiana A.</creator><creator>Steinmetz, Nicholas A.</creator><creator>Gieselmann, Marc A.</creator><creator>Thiele, Alexander</creator><creator>Moore, Tirin</creator><creator>Boahen, Kwabena</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20161202</creationdate><title>Selective modulation of cortical state during spatial attention</title><author>Engel, Tatiana A. ; Steinmetz, Nicholas A. ; Gieselmann, Marc A. ; Thiele, Alexander ; Moore, Tirin ; Boahen, Kwabena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-8599717efce3aaf77daf7a6457c0cad8aaaaf74afbd082909f55facca3d1e32f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animal behavior</topic><topic>Animal cognition</topic><topic>Animals</topic><topic>Attention</topic><topic>Attention - physiology</topic><topic>Brain</topic><topic>Brain Mapping</topic><topic>Correlation</topic><topic>Dynamics</topic><topic>Electrodes</topic><topic>Fluctuation</topic><topic>Goals</topic><topic>Macaca mulatta</topic><topic>Male</topic><topic>Modulation</topic><topic>Monkeys & apes</topic><topic>Nerve Net - physiology</topic><topic>Neurobiology</topic><topic>Phases</topic><topic>Spiking</topic><topic>Visual Cortex - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Engel, Tatiana A.</creatorcontrib><creatorcontrib>Steinmetz, Nicholas A.</creatorcontrib><creatorcontrib>Gieselmann, Marc A.</creatorcontrib><creatorcontrib>Thiele, Alexander</creatorcontrib><creatorcontrib>Moore, Tirin</creatorcontrib><creatorcontrib>Boahen, Kwabena</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Engel, Tatiana A.</au><au>Steinmetz, Nicholas A.</au><au>Gieselmann, Marc A.</au><au>Thiele, Alexander</au><au>Moore, Tirin</au><au>Boahen, Kwabena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selective modulation of cortical state during spatial attention</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2016-12-02</date><risdate>2016</risdate><volume>354</volume><issue>6316</issue><spage>1140</spage><epage>1144</epage><pages>1140-1144</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Neocortical activity is permeated with endogenously generated fluctuations, but how these dynamics affect goal-directed behavior remains a mystery. We found that ensemble neural activity in primate visual cortex spontaneously fluctuated between phases of vigorous (On) and faint (Off) spiking synchronously across cortical layers. These On-Off dynamics, reflecting global changes in cortical state, were also modulated at a local scale during selective attention. Moreover, the momentary phase of local ensemble activity predicted behavioral performance. Our results show that cortical state is controlled locally within a cortical map according to cognitive demands and reveal the impact of these local changes in cortical state on goal-directed behavior.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>27934763</pmid><doi>10.1126/science.aag1420</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2016-12, Vol.354 (6316), p.1140-1144 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1880014762 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Animal behavior Animal cognition Animals Attention Attention - physiology Brain Brain Mapping Correlation Dynamics Electrodes Fluctuation Goals Macaca mulatta Male Modulation Monkeys & apes Nerve Net - physiology Neurobiology Phases Spiking Visual Cortex - physiology |
| title | Selective modulation of cortical state during spatial attention |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T16%3A28%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Selective%20modulation%20of%20cortical%20state%20during%20spatial%20attention&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Engel,%20Tatiana%20A.&rft.date=2016-12-02&rft.volume=354&rft.issue=6316&rft.spage=1140&rft.epage=1144&rft.pages=1140-1144&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.aag1420&rft_dat=%3Cjstor_proqu%3E44711117%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1845274806&rft_id=info:pmid/27934763&rft_jstor_id=44711117&rfr_iscdi=true |