Depleting dietary valine permits nonmyeloablative mouse hematopoietic stem cell transplantation

A specialized bone marrow microenvironment (niche) regulates hematopoietic stem cell (HSC) self-renewal and commitment. For successful donor-HSC engraftment, the niche must be emptied via myeloablative irradiation or chemotherapy. However, myeloablation can cause severe complications and even mortal...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2016-12, Vol.354 (6316), p.1152-1155
Hauptverfasser:	Taya, Yuki, Ota, Yasunori, Wilkinson, Adam C., Kanazawa, Ayano, Watarai, Hiroshi, Kasai, Masataka, Nakauchi, Hiromitsu, Yamazaki, Satoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Blood Bone marrow Cell Proliferation Constrictions Cysteine - deficiency Diet Female Hematopoiesis - physiology Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cells - physiology Hierarchies Humans Iatrogenic Disease Maintenance Metabolism Mice Mice, Inbred C57BL Stem Cell Niche - physiology Stem cells Transplantation Valine Valine - deficiency Valine - physiology
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