Sex ratio of the offspring of New Zealand phenoxy herbicide producers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin
ObjectivesExposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has inconsistently been associated with a decreased sex ratio of the offspring (number of male births divided by total births). We conducted a study among men and women who were employed in a New Zealand phenoxy herbicide production pl...
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| Veröffentlicht in: | Occupational and environmental medicine (London, England) England), 2017-01, Vol.74 (1), p.24-29 |
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| creator | ‘t Mannetje, Andrea Eng, Amanda Walls, Chris Dryson, Evan Kogevinas, Manolis Brooks, Collin McLean, Dave Cheng, Soo Smith, Allan H Pearce, Neil |
| description | ObjectivesExposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has inconsistently been associated with a decreased sex ratio of the offspring (number of male births divided by total births). We conducted a study among men and women who were employed in a New Zealand phenoxy herbicide production plant between 1969 and 1984, to study their offspring sex ratio in relation to their back-calculated TCDD serum concentrations determined in 2007/2008.MethodsA total of 127 men and 21 women reported that 355 children were conceived after starting employment at the plant. The association between their lipid-standardised TCDD serum concentrations back-calculated to the time of their offspring's birth and the probability of a male birth was estimated through logistic regression, adjusting for the age of the exposed parent at birth, current body mass index and smoking.ResultsThe overall sex ratio was 0.55 (197 boys, 158 girls). For fathers with serum TCDD concentrations ≥20 pg/g lipid at time of birth, the sex ratio was 0.47 (OR 0.49; 95% CI 0.30 to 0.79). The probability of a male birth decreased with higher paternal serum TCDD at time of birth ( |
| doi_str_mv | 10.1136/oemed-2016-103771 |
| format | Article |
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We conducted a study among men and women who were employed in a New Zealand phenoxy herbicide production plant between 1969 and 1984, to study their offspring sex ratio in relation to their back-calculated TCDD serum concentrations determined in 2007/2008.MethodsA total of 127 men and 21 women reported that 355 children were conceived after starting employment at the plant. The association between their lipid-standardised TCDD serum concentrations back-calculated to the time of their offspring's birth and the probability of a male birth was estimated through logistic regression, adjusting for the age of the exposed parent at birth, current body mass index and smoking.ResultsThe overall sex ratio was 0.55 (197 boys, 158 girls). For fathers with serum TCDD concentrations ≥20 pg/g lipid at time of birth, the sex ratio was 0.47 (OR 0.49; 95% CI 0.30 to 0.79). The probability of a male birth decreased with higher paternal serum TCDD at time of birth (<4; 4–20; 20–100; ≥100 pg/g lipid), with ORs of 1.00 (reference); 1.00 (95% CI 0.50 to 2.02); 0.52 (95% CI 0.29 to 0.92); 0.45 (95% CI 0.23 to 0.89), p trend 0.007. For exposed mothers, the sex ratio was not reduced.ConclusionsThis study indicates that paternal serum TCDD concentrations in excess of an estimated 20 pg/g lipid at time of conception are associated with a reduced sex ratio.</description><identifier>ISSN: 1351-0711</identifier><identifier>EISSN: 1470-7926</identifier><identifier>DOI: 10.1136/oemed-2016-103771</identifier><identifier>PMID: 27581706</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd</publisher><subject>Adult ; Birth ; Births ; Body Mass Index ; Cohort Studies ; Dioxins ; Dioxins - adverse effects ; Dioxins - blood ; Exposure ; Female ; Herbicides ; Herbicides - adverse effects ; Humans ; Industry ; International Agencies ; Interviews as Topic ; Lipids ; Logistic Models ; Male ; Males ; Men ; Middle Aged ; New Zealand ; Occupational Exposure - adverse effects ; Offspring ; Paternal Exposure - adverse effects ; Pregnancy ; Ratios ; Serums ; Sex ; Sex Distribution ; Sex Ratio ; Sexes ; Studies ; TCDD ; Workplace ; Young Adult</subject><ispartof>Occupational and environmental medicine (London, England), 2017-01, Vol.74 (1), p.24-29</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing</rights><rights>2016 BMJ Publishing Group</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.</rights><rights>Copyright: 2016 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b567t-893735ba41181f03b6632e39d389821751eca0ee65274c0c4b604da1ce4266573</citedby><cites>FETCH-LOGICAL-b567t-893735ba41181f03b6632e39d389821751eca0ee65274c0c4b604da1ce4266573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/44134269$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/44134269$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27581706$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>‘t Mannetje, Andrea</creatorcontrib><creatorcontrib>Eng, Amanda</creatorcontrib><creatorcontrib>Walls, Chris</creatorcontrib><creatorcontrib>Dryson, Evan</creatorcontrib><creatorcontrib>Kogevinas, Manolis</creatorcontrib><creatorcontrib>Brooks, Collin</creatorcontrib><creatorcontrib>McLean, Dave</creatorcontrib><creatorcontrib>Cheng, Soo</creatorcontrib><creatorcontrib>Smith, Allan H</creatorcontrib><creatorcontrib>Pearce, Neil</creatorcontrib><title>Sex ratio of the offspring of New Zealand phenoxy herbicide producers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin</title><title>Occupational and environmental medicine (London, England)</title><addtitle>Occup Environ Med</addtitle><description>ObjectivesExposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has inconsistently been associated with a decreased sex ratio of the offspring (number of male births divided by total births). We conducted a study among men and women who were employed in a New Zealand phenoxy herbicide production plant between 1969 and 1984, to study their offspring sex ratio in relation to their back-calculated TCDD serum concentrations determined in 2007/2008.MethodsA total of 127 men and 21 women reported that 355 children were conceived after starting employment at the plant. The association between their lipid-standardised TCDD serum concentrations back-calculated to the time of their offspring's birth and the probability of a male birth was estimated through logistic regression, adjusting for the age of the exposed parent at birth, current body mass index and smoking.ResultsThe overall sex ratio was 0.55 (197 boys, 158 girls). For fathers with serum TCDD concentrations ≥20 pg/g lipid at time of birth, the sex ratio was 0.47 (OR 0.49; 95% CI 0.30 to 0.79). The probability of a male birth decreased with higher paternal serum TCDD at time of birth (<4; 4–20; 20–100; ≥100 pg/g lipid), with ORs of 1.00 (reference); 1.00 (95% CI 0.50 to 2.02); 0.52 (95% CI 0.29 to 0.92); 0.45 (95% CI 0.23 to 0.89), p trend 0.007. For exposed mothers, the sex ratio was not reduced.ConclusionsThis study indicates that paternal serum TCDD concentrations in excess of an estimated 20 pg/g lipid at time of conception are associated with a reduced sex ratio.</description><subject>Adult</subject><subject>Birth</subject><subject>Births</subject><subject>Body Mass Index</subject><subject>Cohort Studies</subject><subject>Dioxins</subject><subject>Dioxins - adverse effects</subject><subject>Dioxins - blood</subject><subject>Exposure</subject><subject>Female</subject><subject>Herbicides</subject><subject>Herbicides - adverse effects</subject><subject>Humans</subject><subject>Industry</subject><subject>International Agencies</subject><subject>Interviews as Topic</subject><subject>Lipids</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Males</subject><subject>Men</subject><subject>Middle Aged</subject><subject>New Zealand</subject><subject>Occupational Exposure - adverse effects</subject><subject>Offspring</subject><subject>Paternal Exposure - adverse effects</subject><subject>Pregnancy</subject><subject>Ratios</subject><subject>Serums</subject><subject>Sex</subject><subject>Sex Distribution</subject><subject>Sex Ratio</subject><subject>Sexes</subject><subject>Studies</subject><subject>TCDD</subject><subject>Workplace</subject><subject>Young Adult</subject><issn>1351-0711</issn><issn>1470-7926</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkbuO1DAUhi0EYi_wABQgSzQUY_DxNSnRChakFRRAQxM5zgmT0UwcbEfM8vQ4ZJeCaqpj-f_O9SfkGfDXANK8CXjAjgkOhgGX1sIDcg7KcmZrYR6Wt9TAuAU4Ixcp7TgHaaV4TM6E1RVYbs5J_oJHGl0eAg09zVssoU9THMYfy8cn_EW_o9u7saPTFsdwvKVbjO3ghw7pFEM3e4yJ4nEKCTuaAxUbubGbimXM0fntPhRoaHH8HdjEuiEch_EJedS7fcKnd_GSfHv_7uvVB3bz-frj1dsb1mpjM6vqMq5unQKooOeyNUYKlHUnq7oSYDWgdxzRaGGV5161hqvOgUcljNFWXpJXa90y6M8ZU24OQ_K4L-tgmFMDVVVuorgQJ6C6VpVQmp-CCqO15KqgL_9Dd2GOY9l56S1tbU299IaV8jGkFLFvyv0PLt42wJvF6Oav0c1idLMaXXJe3FWe20W7z7h3tgDPV2CXcoj_dKVAluvURd-senvYndDvD4c7uVI</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>‘t Mannetje, Andrea</creator><creator>Eng, Amanda</creator><creator>Walls, Chris</creator><creator>Dryson, Evan</creator><creator>Kogevinas, Manolis</creator><creator>Brooks, Collin</creator><creator>McLean, Dave</creator><creator>Cheng, Soo</creator><creator>Smith, Allan H</creator><creator>Pearce, Neil</creator><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>L6V</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>7X8</scope><scope>7T2</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope><scope>7QQ</scope><scope>7TA</scope><scope>7TB</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>KR7</scope></search><sort><creationdate>20170101</creationdate><title>Sex ratio of the offspring of New Zealand phenoxy herbicide producers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin</title><author>‘t Mannetje, Andrea ; Eng, Amanda ; Walls, Chris ; Dryson, Evan ; Kogevinas, Manolis ; Brooks, Collin ; McLean, Dave ; Cheng, Soo ; Smith, Allan H ; Pearce, Neil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b567t-893735ba41181f03b6632e39d389821751eca0ee65274c0c4b604da1ce4266573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Birth</topic><topic>Births</topic><topic>Body Mass Index</topic><topic>Cohort Studies</topic><topic>Dioxins</topic><topic>Dioxins - adverse effects</topic><topic>Dioxins - blood</topic><topic>Exposure</topic><topic>Female</topic><topic>Herbicides</topic><topic>Herbicides - adverse effects</topic><topic>Humans</topic><topic>Industry</topic><topic>International Agencies</topic><topic>Interviews as Topic</topic><topic>Lipids</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Males</topic><topic>Men</topic><topic>Middle Aged</topic><topic>New Zealand</topic><topic>Occupational Exposure - adverse effects</topic><topic>Offspring</topic><topic>Paternal Exposure - adverse effects</topic><topic>Pregnancy</topic><topic>Ratios</topic><topic>Serums</topic><topic>Sex</topic><topic>Sex Distribution</topic><topic>Sex Ratio</topic><topic>Sexes</topic><topic>Studies</topic><topic>TCDD</topic><topic>Workplace</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>‘t Mannetje, Andrea</creatorcontrib><creatorcontrib>Eng, Amanda</creatorcontrib><creatorcontrib>Walls, Chris</creatorcontrib><creatorcontrib>Dryson, Evan</creatorcontrib><creatorcontrib>Kogevinas, Manolis</creatorcontrib><creatorcontrib>Brooks, Collin</creatorcontrib><creatorcontrib>McLean, Dave</creatorcontrib><creatorcontrib>Cheng, Soo</creatorcontrib><creatorcontrib>Smith, Allan H</creatorcontrib><creatorcontrib>Pearce, Neil</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Engineering Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Ceramic Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Civil Engineering Abstracts</collection><jtitle>Occupational and environmental medicine (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>‘t Mannetje, Andrea</au><au>Eng, Amanda</au><au>Walls, Chris</au><au>Dryson, Evan</au><au>Kogevinas, Manolis</au><au>Brooks, Collin</au><au>McLean, Dave</au><au>Cheng, Soo</au><au>Smith, Allan H</au><au>Pearce, Neil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex ratio of the offspring of New Zealand phenoxy herbicide producers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin</atitle><jtitle>Occupational and environmental medicine (London, England)</jtitle><addtitle>Occup Environ Med</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>74</volume><issue>1</issue><spage>24</spage><epage>29</epage><pages>24-29</pages><issn>1351-0711</issn><eissn>1470-7926</eissn><abstract>ObjectivesExposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has inconsistently been associated with a decreased sex ratio of the offspring (number of male births divided by total births). We conducted a study among men and women who were employed in a New Zealand phenoxy herbicide production plant between 1969 and 1984, to study their offspring sex ratio in relation to their back-calculated TCDD serum concentrations determined in 2007/2008.MethodsA total of 127 men and 21 women reported that 355 children were conceived after starting employment at the plant. The association between their lipid-standardised TCDD serum concentrations back-calculated to the time of their offspring's birth and the probability of a male birth was estimated through logistic regression, adjusting for the age of the exposed parent at birth, current body mass index and smoking.ResultsThe overall sex ratio was 0.55 (197 boys, 158 girls). For fathers with serum TCDD concentrations ≥20 pg/g lipid at time of birth, the sex ratio was 0.47 (OR 0.49; 95% CI 0.30 to 0.79). The probability of a male birth decreased with higher paternal serum TCDD at time of birth (<4; 4–20; 20–100; ≥100 pg/g lipid), with ORs of 1.00 (reference); 1.00 (95% CI 0.50 to 2.02); 0.52 (95% CI 0.29 to 0.92); 0.45 (95% CI 0.23 to 0.89), p trend 0.007. For exposed mothers, the sex ratio was not reduced.ConclusionsThis study indicates that paternal serum TCDD concentrations in excess of an estimated 20 pg/g lipid at time of conception are associated with a reduced sex ratio.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd</pub><pmid>27581706</pmid><doi>10.1136/oemed-2016-103771</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Jstor Complete Legacy; MEDLINE |
| subjects | Adult Birth Births Body Mass Index Cohort Studies Dioxins Dioxins - adverse effects Dioxins - blood Exposure Female Herbicides Herbicides - adverse effects Humans Industry International Agencies Interviews as Topic Lipids Logistic Models Male Males Men Middle Aged New Zealand Occupational Exposure - adverse effects Offspring Paternal Exposure - adverse effects Pregnancy Ratios Serums Sex Sex Distribution Sex Ratio Sexes Studies TCDD Workplace Young Adult |
| title | Sex ratio of the offspring of New Zealand phenoxy herbicide producers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin |
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