Pair correlation microscopy reveals the role of nanoparticle shape in intracellular transport and site of drug release

Nanoparticle size, surface charge and material composition are known to affect the uptake of nanoparticles by cells. However, whether nanoparticle shape affects transport across various barriers inside the cell remains unclear. Here we used pair correlation microscopy to show that polymeric nanopart...

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Veröffentlicht in:	Nature nanotechnology 2017, Vol.12 (1), p.81-89
Hauptverfasser:	Hinde, Elizabeth, Thammasiraphop, Kitiphume, Duong, Hien T. T., Yeow, Jonathan, Karagoz, Bunyamin, Boyer, Cyrille, Gooding, J. Justin, Gaus, Katharina
Format:	Artikel
Sprache:	eng
Schlagworte:	631/61/350/354 639/925/352/2734 Barriers Cell size Chemistry Correlation Cytoplasm Cytotoxicity Diffusion barriers Diffusion rate Doxorubicin Drug delivery Drug delivery systems Localization Materials Science Micelles Microscopy Nanoparticles Nanostructure Nanotechnology Nanotechnology and Microengineering Nuclear pores Nuclei Nuclei (cytology) Rods Surface charge Vesicles Worms
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