Mimicking Drug–Substrate Interaction: A Smart Bioinspired Technology for the Fabrication of Theranostic Nanoprobes

Versatile bioinspired strategies are urgently needed to fabricate high‐performance nanoprobes for biomedical application. Herein, a novel bioinspired technology of mimicking drug–substrate interaction is reported for the fabrication of high‐performance nanoprobes. As a proof of concept, a multifunct...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Advanced functional materials 2017-01, Vol.27 (3), p.1603440-n/a
Hauptverfasser: Pan, Jinbin, Wang, Yaqiong, Pan, Haiyan, Zhang, Cai, Zhang, Xiaogang, Fu, Yan‐Yan, Zhang, Xuejun, Yu, Chunshui, Sun, Shao‐Kai, Yan, Xiu‐Ping
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page n/a
container_issue 3
container_start_page 1603440
container_title Advanced functional materials
container_volume 27
creator Pan, Jinbin
Wang, Yaqiong
Pan, Haiyan
Zhang, Cai
Zhang, Xiaogang
Fu, Yan‐Yan
Zhang, Xuejun
Yu, Chunshui
Sun, Shao‐Kai
Yan, Xiu‐Ping
description Versatile bioinspired strategies are urgently needed to fabricate high‐performance nanoprobes for biomedical application. Herein, a novel bioinspired technology of mimicking drug–substrate interaction is reported for the fabrication of high‐performance nanoprobes. As a proof of concept, a multifunctional bovine serum albumin (BSA)‐MnO2 nanoparticle‐based nanoplatform is strategically engineered via mimicking the disinfection process of KMnO4 in an extremely facile way. The prepared BSA‐MnO2 nanoparticles possess sub‐10 nm and uniform size, excellent colloidal stability, and impressive T1 relaxivity of 7.9 mm−1 s−1. The proposed nanoprobe could not only be employed as a high‐performance magnetic resonance imaging (MRI) agent for tumor and renal imaging but can also provide a platform for integrating therapeutic strategies toward tumors. The universal strategy could also be easily extended to the fabrication of other nanoprobes for MR imaging in vivo using other bioactive proteins including ovalbumin and transferrin. This work will open a new way for the development of biomaterials in biomedicine applications. A universal bioinspired strategy is proposed for the fabrication of versatile nanoprobes. The nanoprobe synthesized by mimicking the drug–substrate interaction could not only be employed as a high‐performance magnetic resonance imaging (MRI) agent for tumor and renal imaging but can also provide a platform for integrating therapeutic strategies toward tumors.
doi_str_mv 10.1002/adfm.201603440
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1879996548</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1920431729</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3870-e4430039ce8b7a98bcbcf751e64a1e3b8b70b208e8f59c84f562c65728c4c6cc3</originalsourceid><addsrcrecordid>eNqFkT1v2zAQhoWgAfLVNTOBLlnskCIlkdlcO04N5GOIC2QjqMvJZiqLLkkh8Nb_kH-YX1IaLhwgS6d7cXjeu8O9WXbO6JBRml-a52Y1zCkrKReCHmTHrGTlgNNcftlr9nSUnYTwQimrKi6Os3hnVxZ-2W5BJr5fvP95e-zrEL2JSGZdRG8gWtddkRF5XBkfyXfrbBfW1uMzmSMsO9e6xYY0zpO4RDI1tbdgth7iGjJfpgmdC9ECuU9i7V2N4Sw7bEwb8Ou_epr9nF7Pxz8Gtw83s_HodgBcVnSAQnBKuQKUdWWUrKGGpioYlsIw5HXq0jqnEmVTKJCiKcocyqLKJQgoAfhpdrGbm9b-7jFEvbIBsG1Nh64PmslKKVUWQib02yf0xfW-S9dppnIqOKtylajhjgLvQvDY6LW36S0bzajehqC3Ieh9CMmgdoZX2-LmP7QeTaZ3H96_XsyNRw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1920431729</pqid></control><display><type>article</type><title>Mimicking Drug–Substrate Interaction: A Smart Bioinspired Technology for the Fabrication of Theranostic Nanoprobes</title><source>Access via Wiley Online Library</source><creator>Pan, Jinbin ; Wang, Yaqiong ; Pan, Haiyan ; Zhang, Cai ; Zhang, Xiaogang ; Fu, Yan‐Yan ; Zhang, Xuejun ; Yu, Chunshui ; Sun, Shao‐Kai ; Yan, Xiu‐Ping</creator><creatorcontrib>Pan, Jinbin ; Wang, Yaqiong ; Pan, Haiyan ; Zhang, Cai ; Zhang, Xiaogang ; Fu, Yan‐Yan ; Zhang, Xuejun ; Yu, Chunshui ; Sun, Shao‐Kai ; Yan, Xiu‐Ping</creatorcontrib><description>Versatile bioinspired strategies are urgently needed to fabricate high‐performance nanoprobes for biomedical application. Herein, a novel bioinspired technology of mimicking drug–substrate interaction is reported for the fabrication of high‐performance nanoprobes. As a proof of concept, a multifunctional bovine serum albumin (BSA)‐MnO2 nanoparticle‐based nanoplatform is strategically engineered via mimicking the disinfection process of KMnO4 in an extremely facile way. The prepared BSA‐MnO2 nanoparticles possess sub‐10 nm and uniform size, excellent colloidal stability, and impressive T1 relaxivity of 7.9 mm−1 s−1. The proposed nanoprobe could not only be employed as a high‐performance magnetic resonance imaging (MRI) agent for tumor and renal imaging but can also provide a platform for integrating therapeutic strategies toward tumors. The universal strategy could also be easily extended to the fabrication of other nanoprobes for MR imaging in vivo using other bioactive proteins including ovalbumin and transferrin. This work will open a new way for the development of biomaterials in biomedicine applications. A universal bioinspired strategy is proposed for the fabrication of versatile nanoprobes. The nanoprobe synthesized by mimicking the drug–substrate interaction could not only be employed as a high‐performance magnetic resonance imaging (MRI) agent for tumor and renal imaging but can also provide a platform for integrating therapeutic strategies toward tumors.</description><identifier>ISSN: 1616-301X</identifier><identifier>EISSN: 1616-3028</identifier><identifier>DOI: 10.1002/adfm.201603440</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc</publisher><subject>Biocompatibility ; bioinspired technology ; Biomedical materials ; Colloids ; drug–substrate interaction ; Imaging ; Magnetic resonance imaging ; Materials science ; MnO2 nanoparticles ; Nanoparticles ; Nanostructure ; NMR ; Nuclear magnetic resonance ; Ovalbumin ; Platforms ; Proteins ; Serum albumin ; Strategy ; Surgical implants ; theranostic nanoprobes ; Transferrin ; Tumors</subject><ispartof>Advanced functional materials, 2017-01, Vol.27 (3), p.1603440-n/a</ispartof><rights>2016 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim</rights><rights>Copyright © 2017 WILEY-VCH Verlag GmbH &amp; Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3870-e4430039ce8b7a98bcbcf751e64a1e3b8b70b208e8f59c84f562c65728c4c6cc3</citedby><cites>FETCH-LOGICAL-c3870-e4430039ce8b7a98bcbcf751e64a1e3b8b70b208e8f59c84f562c65728c4c6cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadfm.201603440$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadfm.201603440$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Pan, Jinbin</creatorcontrib><creatorcontrib>Wang, Yaqiong</creatorcontrib><creatorcontrib>Pan, Haiyan</creatorcontrib><creatorcontrib>Zhang, Cai</creatorcontrib><creatorcontrib>Zhang, Xiaogang</creatorcontrib><creatorcontrib>Fu, Yan‐Yan</creatorcontrib><creatorcontrib>Zhang, Xuejun</creatorcontrib><creatorcontrib>Yu, Chunshui</creatorcontrib><creatorcontrib>Sun, Shao‐Kai</creatorcontrib><creatorcontrib>Yan, Xiu‐Ping</creatorcontrib><title>Mimicking Drug–Substrate Interaction: A Smart Bioinspired Technology for the Fabrication of Theranostic Nanoprobes</title><title>Advanced functional materials</title><description>Versatile bioinspired strategies are urgently needed to fabricate high‐performance nanoprobes for biomedical application. Herein, a novel bioinspired technology of mimicking drug–substrate interaction is reported for the fabrication of high‐performance nanoprobes. As a proof of concept, a multifunctional bovine serum albumin (BSA)‐MnO2 nanoparticle‐based nanoplatform is strategically engineered via mimicking the disinfection process of KMnO4 in an extremely facile way. The prepared BSA‐MnO2 nanoparticles possess sub‐10 nm and uniform size, excellent colloidal stability, and impressive T1 relaxivity of 7.9 mm−1 s−1. The proposed nanoprobe could not only be employed as a high‐performance magnetic resonance imaging (MRI) agent for tumor and renal imaging but can also provide a platform for integrating therapeutic strategies toward tumors. The universal strategy could also be easily extended to the fabrication of other nanoprobes for MR imaging in vivo using other bioactive proteins including ovalbumin and transferrin. This work will open a new way for the development of biomaterials in biomedicine applications. A universal bioinspired strategy is proposed for the fabrication of versatile nanoprobes. The nanoprobe synthesized by mimicking the drug–substrate interaction could not only be employed as a high‐performance magnetic resonance imaging (MRI) agent for tumor and renal imaging but can also provide a platform for integrating therapeutic strategies toward tumors.</description><subject>Biocompatibility</subject><subject>bioinspired technology</subject><subject>Biomedical materials</subject><subject>Colloids</subject><subject>drug–substrate interaction</subject><subject>Imaging</subject><subject>Magnetic resonance imaging</subject><subject>Materials science</subject><subject>MnO2 nanoparticles</subject><subject>Nanoparticles</subject><subject>Nanostructure</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Ovalbumin</subject><subject>Platforms</subject><subject>Proteins</subject><subject>Serum albumin</subject><subject>Strategy</subject><subject>Surgical implants</subject><subject>theranostic nanoprobes</subject><subject>Transferrin</subject><subject>Tumors</subject><issn>1616-301X</issn><issn>1616-3028</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqFkT1v2zAQhoWgAfLVNTOBLlnskCIlkdlcO04N5GOIC2QjqMvJZiqLLkkh8Nb_kH-YX1IaLhwgS6d7cXjeu8O9WXbO6JBRml-a52Y1zCkrKReCHmTHrGTlgNNcftlr9nSUnYTwQimrKi6Os3hnVxZ-2W5BJr5fvP95e-zrEL2JSGZdRG8gWtddkRF5XBkfyXfrbBfW1uMzmSMsO9e6xYY0zpO4RDI1tbdgth7iGjJfpgmdC9ECuU9i7V2N4Sw7bEwb8Ou_epr9nF7Pxz8Gtw83s_HodgBcVnSAQnBKuQKUdWWUrKGGpioYlsIw5HXq0jqnEmVTKJCiKcocyqLKJQgoAfhpdrGbm9b-7jFEvbIBsG1Nh64PmslKKVUWQib02yf0xfW-S9dppnIqOKtylajhjgLvQvDY6LW36S0bzajehqC3Ieh9CMmgdoZX2-LmP7QeTaZ3H96_XsyNRw</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Pan, Jinbin</creator><creator>Wang, Yaqiong</creator><creator>Pan, Haiyan</creator><creator>Zhang, Cai</creator><creator>Zhang, Xiaogang</creator><creator>Fu, Yan‐Yan</creator><creator>Zhang, Xuejun</creator><creator>Yu, Chunshui</creator><creator>Sun, Shao‐Kai</creator><creator>Yan, Xiu‐Ping</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20170101</creationdate><title>Mimicking Drug–Substrate Interaction: A Smart Bioinspired Technology for the Fabrication of Theranostic Nanoprobes</title><author>Pan, Jinbin ; Wang, Yaqiong ; Pan, Haiyan ; Zhang, Cai ; Zhang, Xiaogang ; Fu, Yan‐Yan ; Zhang, Xuejun ; Yu, Chunshui ; Sun, Shao‐Kai ; Yan, Xiu‐Ping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3870-e4430039ce8b7a98bcbcf751e64a1e3b8b70b208e8f59c84f562c65728c4c6cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Biocompatibility</topic><topic>bioinspired technology</topic><topic>Biomedical materials</topic><topic>Colloids</topic><topic>drug–substrate interaction</topic><topic>Imaging</topic><topic>Magnetic resonance imaging</topic><topic>Materials science</topic><topic>MnO2 nanoparticles</topic><topic>Nanoparticles</topic><topic>Nanostructure</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Ovalbumin</topic><topic>Platforms</topic><topic>Proteins</topic><topic>Serum albumin</topic><topic>Strategy</topic><topic>Surgical implants</topic><topic>theranostic nanoprobes</topic><topic>Transferrin</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pan, Jinbin</creatorcontrib><creatorcontrib>Wang, Yaqiong</creatorcontrib><creatorcontrib>Pan, Haiyan</creatorcontrib><creatorcontrib>Zhang, Cai</creatorcontrib><creatorcontrib>Zhang, Xiaogang</creatorcontrib><creatorcontrib>Fu, Yan‐Yan</creatorcontrib><creatorcontrib>Zhang, Xuejun</creatorcontrib><creatorcontrib>Yu, Chunshui</creatorcontrib><creatorcontrib>Sun, Shao‐Kai</creatorcontrib><creatorcontrib>Yan, Xiu‐Ping</creatorcontrib><collection>CrossRef</collection><collection>Electronics &amp; Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Advanced functional materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pan, Jinbin</au><au>Wang, Yaqiong</au><au>Pan, Haiyan</au><au>Zhang, Cai</au><au>Zhang, Xiaogang</au><au>Fu, Yan‐Yan</au><au>Zhang, Xuejun</au><au>Yu, Chunshui</au><au>Sun, Shao‐Kai</au><au>Yan, Xiu‐Ping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mimicking Drug–Substrate Interaction: A Smart Bioinspired Technology for the Fabrication of Theranostic Nanoprobes</atitle><jtitle>Advanced functional materials</jtitle><date>2017-01-01</date><risdate>2017</risdate><volume>27</volume><issue>3</issue><spage>1603440</spage><epage>n/a</epage><pages>1603440-n/a</pages><issn>1616-301X</issn><eissn>1616-3028</eissn><abstract>Versatile bioinspired strategies are urgently needed to fabricate high‐performance nanoprobes for biomedical application. Herein, a novel bioinspired technology of mimicking drug–substrate interaction is reported for the fabrication of high‐performance nanoprobes. As a proof of concept, a multifunctional bovine serum albumin (BSA)‐MnO2 nanoparticle‐based nanoplatform is strategically engineered via mimicking the disinfection process of KMnO4 in an extremely facile way. The prepared BSA‐MnO2 nanoparticles possess sub‐10 nm and uniform size, excellent colloidal stability, and impressive T1 relaxivity of 7.9 mm−1 s−1. The proposed nanoprobe could not only be employed as a high‐performance magnetic resonance imaging (MRI) agent for tumor and renal imaging but can also provide a platform for integrating therapeutic strategies toward tumors. The universal strategy could also be easily extended to the fabrication of other nanoprobes for MR imaging in vivo using other bioactive proteins including ovalbumin and transferrin. This work will open a new way for the development of biomaterials in biomedicine applications. A universal bioinspired strategy is proposed for the fabrication of versatile nanoprobes. The nanoprobe synthesized by mimicking the drug–substrate interaction could not only be employed as a high‐performance magnetic resonance imaging (MRI) agent for tumor and renal imaging but can also provide a platform for integrating therapeutic strategies toward tumors.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/adfm.201603440</doi><tpages>10</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1616-301X
ispartof Advanced functional materials, 2017-01, Vol.27 (3), p.1603440-n/a
issn 1616-301X
1616-3028
language eng
recordid cdi_proquest_miscellaneous_1879996548
source Access via Wiley Online Library
subjects Biocompatibility
bioinspired technology
Biomedical materials
Colloids
drug–substrate interaction
Imaging
Magnetic resonance imaging
Materials science
MnO2 nanoparticles
Nanoparticles
Nanostructure
NMR
Nuclear magnetic resonance
Ovalbumin
Platforms
Proteins
Serum albumin
Strategy
Surgical implants
theranostic nanoprobes
Transferrin
Tumors
title Mimicking Drug–Substrate Interaction: A Smart Bioinspired Technology for the Fabrication of Theranostic Nanoprobes
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T10%3A06%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mimicking%20Drug%E2%80%93Substrate%20Interaction:%20A%20Smart%20Bioinspired%20Technology%20for%20the%20Fabrication%20of%20Theranostic%20Nanoprobes&rft.jtitle=Advanced%20functional%20materials&rft.au=Pan,%20Jinbin&rft.date=2017-01-01&rft.volume=27&rft.issue=3&rft.spage=1603440&rft.epage=n/a&rft.pages=1603440-n/a&rft.issn=1616-301X&rft.eissn=1616-3028&rft_id=info:doi/10.1002/adfm.201603440&rft_dat=%3Cproquest_cross%3E1920431729%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1920431729&rft_id=info:pmid/&rfr_iscdi=true