Bioconjugation strategies to couple supramolecular exo-functionalized palladium cages to peptides for biomedical applications

Supramolecular Pd L cages (L = ligand) hold promise as drug delivery systems. With the idea of achieving targeted delivery of the metallacages to tumor cells, the bioconjugation of exo-functionalized self-assembled Pd L cages to peptides following two different approaches is reported for the first t...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2017, Vol.53 (8), p.1405-1408
Hauptverfasser:	Han, J, Schmidt, A, Zhang, T, Permentier, H, Groothuis, G M M, Bischoff, R, Kühn, F E, Horvatovich, P, Casini, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical materials Biomedical Research Cages Couples Drug Delivery Systems Ligands Macromolecular Substances - chemistry Mass Spectrometry Organometallic Compounds - chemistry Palladium - chemistry Peptides Peptides - chemistry Strategy
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Beschreibung
Zusammenfassung:	Supramolecular Pd L cages (L = ligand) hold promise as drug delivery systems. With the idea of achieving targeted delivery of the metallacages to tumor cells, the bioconjugation of exo-functionalized self-assembled Pd L cages to peptides following two different approaches is reported for the first time. The obtained bioconjugates were analyzed and identified by high-resolution mass spectrometry.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c6cc08937b