Derivatization Strategies for the Detection of Triamcinolone Acetonide in Cartilage by Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

Osteoarthritis (OA), characterized by degeneration of the cartilaginous tissue in articular joints, severely impairs mobility in many people worldwide. The degeneration is thought to be mediated by inflammatory processes occurring in the tissue of the joint, including the cartilage. Intra-articular...

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Veröffentlicht in:	Analytical chemistry (Washington) 2016-12, Vol.88 (24), p.12051-12059
Hauptverfasser:	Barré, Florian P. Y, Flinders, Bryn, Garcia, João P, Jansen, Imke, Huizing, Lennart R. S, Porta, Tiffany, Creemers, Laura B, Heeren, Ron M. A, Cillero-Pastor, Berta
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents - analysis Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - therapeutic use Betaine - analogs & derivatives Betaine - chemistry Cartilage Cartilage - chemistry Cartilage - metabolism Cartilage - pathology Desorption Drugs Humans Imaging Ionization Ions Lasers Mass spectrometry Matrix Osteoarthritis - drug therapy Osteoarthritis - metabolism Osteoarthritis - pathology Penetration Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Steroids Triamcinolone Acetonide - analysis Triamcinolone Acetonide - chemistry Triamcinolone Acetonide - therapeutic use
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