Probing the Lysine Proximal Microenvironments within Membrane Protein Complexes by Active Dimethyl Labeling and Mass Spectrometry

Positively charged lysines are crucial to maintaining the native structures of proteins and protein complexes by forming hydrogen bonds and electrostatic interactions with their proximal amino acid residues. However, it is still a challenge to develop an efficient method for probing the active proxi...

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Veröffentlicht in:	Analytical chemistry (Washington) 2016-12, Vol.88 (24), p.12060-12065
Hauptverfasser:	Zhou, Ye, Wu, Yue, Yao, Mingdong, Liu, Zheyi, Chen, Jin, Chen, Jun, Tian, Lirong, Han, Guangye, Shen, Jian-Ren, Wang, Fangjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Algae Bacteria Cyanobacteria Hydrogen bonds Labels Lysine Marking Mass spectrometry Membranes Photosynthesis Proteins Spinacia oleracea Strategy
Online-Zugang:	Volltext
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