Nature-Inspired Smart DNA Nanodoctor for Activatable In Vivo Cancer Imaging and In Situ Drug Release Based on Recognition-Triggered Assembly of Split Aptamer

DNA-based activatable theranostic nanoprobes are still unmet for in vivo applications. Here, by utilizing the “induced-fit effect”, a smart split aptamer-based activatable theranostic probe (SATP) was first designed as “nanodoctor” for cancer-activated in vivo imaging and in situ drug release. The S...

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