Electrochemical design of a new nanosensor based on cobalt nanoparticles, chitosan and MWCNT for the determination of daclatasvir: a hepatitis C antiviral drug
Daclatasvir (DAC) is listed on the World Health Organization's list of essential medicines needed in a basic health system, therefore, electrochemical and impedance spectroscopic methods are necessary to obtain information about its mechanism using a carbon paste electrode (CPE) modified with c...
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| Veröffentlicht in: | RSC advances 2017-01, Vol.7 (2), p.1118-1126 |
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| creator | Azab, Shereen M Fekry, Amany M |
| description | Daclatasvir (DAC) is listed on the World Health Organization's list of essential medicines needed in a basic health system, therefore, electrochemical and impedance spectroscopic methods are necessary to obtain information about its mechanism using a carbon paste electrode (CPE) modified with chitosan (Cs)/multi-walled carbon nanotubes (CNT) and cobalt nanoparticles (CoNps). The simultaneous determination of DAC with the hepatitis B antiviral drug entecavir (ENT) was also investigated by differential pulse voltammetry in universal buffer pH 2.0. The experimental results specify a linear relation between the DAC peak current and its concentration in the range from 1.0 nM to 12 μM, leading to a detection limit of 8.82 × 10
−10
M. Finally, this novel sensor was successfully used to determine DAC in human biological fluids such as urine, blood serum and in pharmaceutical formulations.
Daclatasvir (DAC) is listed on the World Health Organization's list of essential medicines needed in a basic health system, therefore, electrochemical and impedance spectroscopic methods are necessary. |
| doi_str_mv | 10.1039/c6ra25826c |
| format | Article |
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−10
M. Finally, this novel sensor was successfully used to determine DAC in human biological fluids such as urine, blood serum and in pharmaceutical formulations.
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−10
M. Finally, this novel sensor was successfully used to determine DAC in human biological fluids such as urine, blood serum and in pharmaceutical formulations.
Daclatasvir (DAC) is listed on the World Health Organization's list of essential medicines needed in a basic health system, therefore, electrochemical and impedance spectroscopic methods are necessary.</description><subject>Carbon</subject><subject>Chitosan</subject><subject>Cobalt</subject><subject>Drugs</subject><subject>Health</subject><subject>Hepatitis B virus</subject><subject>Hepatitis C virus</subject><subject>Multi wall carbon nanotubes</subject><subject>Nanoparticles</subject><subject>Nanostructure</subject><issn>2046-2069</issn><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqNkUFP3DAQhaMKpCLgwr2Se0OIBduJvQ43FEFBoq2EqHqMJs6EdZW1g8dLxa_pX63ZrQonhC9j-X3zxqNXFAeCnwhe1qdWR5DKSG0_FDuSV3omua63Xt0_FvtEv3g-WgmpxU7x52JEm2KwC1w6CyPrkdy9Z2FgwDz-Zh58IPQUIuuAsGfBMxs6GNNamiAmZ0ekY2YXLgUCz8D37OvP5tsdG3JXWmA2TRiXzkNyYe3dgx0hAT26eJYHLXDKUnLEmtydXH5-_kpc3e8V2wOMhPv_6m7x4_Lirrma3Xz_ct2c38xsaUSazbGrOmtxMFKCqpUALitTVTVUlQA1N7yuyrz2oKRQatAd9NoaU3KoOSBAuVscbnynGB5WSKldOrI4juAxrKgVZl7XxsxL9Q5Um1KaPD6jRxvUxkAUcWin6JYQn1rB2-fM2kbfnq8zazL8aQNHsv-5l0yz_vktvZ36ofwLMfCgKw</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Azab, Shereen M</creator><creator>Fekry, Amany M</creator><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7SR</scope><scope>8BQ</scope><scope>JG9</scope></search><sort><creationdate>20170101</creationdate><title>Electrochemical design of a new nanosensor based on cobalt nanoparticles, chitosan and MWCNT for the determination of daclatasvir: a hepatitis C antiviral drug</title><author>Azab, Shereen M ; Fekry, Amany M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-7eb4bccef822a5951a0248449a441a5780943000f52155f6bad6c8830a90aeaa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Carbon</topic><topic>Chitosan</topic><topic>Cobalt</topic><topic>Drugs</topic><topic>Health</topic><topic>Hepatitis B virus</topic><topic>Hepatitis C virus</topic><topic>Multi wall carbon nanotubes</topic><topic>Nanoparticles</topic><topic>Nanostructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Azab, Shereen M</creatorcontrib><creatorcontrib>Fekry, Amany M</creatorcontrib><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Materials Research Database</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Azab, Shereen M</au><au>Fekry, Amany M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electrochemical design of a new nanosensor based on cobalt nanoparticles, chitosan and MWCNT for the determination of daclatasvir: a hepatitis C antiviral drug</atitle><jtitle>RSC advances</jtitle><date>2017-01-01</date><risdate>2017</risdate><volume>7</volume><issue>2</issue><spage>1118</spage><epage>1126</epage><pages>1118-1126</pages><issn>2046-2069</issn><eissn>2046-2069</eissn><abstract>Daclatasvir (DAC) is listed on the World Health Organization's list of essential medicines needed in a basic health system, therefore, electrochemical and impedance spectroscopic methods are necessary to obtain information about its mechanism using a carbon paste electrode (CPE) modified with chitosan (Cs)/multi-walled carbon nanotubes (CNT) and cobalt nanoparticles (CoNps). The simultaneous determination of DAC with the hepatitis B antiviral drug entecavir (ENT) was also investigated by differential pulse voltammetry in universal buffer pH 2.0. The experimental results specify a linear relation between the DAC peak current and its concentration in the range from 1.0 nM to 12 μM, leading to a detection limit of 8.82 × 10
−10
M. Finally, this novel sensor was successfully used to determine DAC in human biological fluids such as urine, blood serum and in pharmaceutical formulations.
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| ispartof | RSC advances, 2017-01, Vol.7 (2), p.1118-1126 |
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| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Carbon Chitosan Cobalt Drugs Health Hepatitis B virus Hepatitis C virus Multi wall carbon nanotubes Nanoparticles Nanostructure |
| title | Electrochemical design of a new nanosensor based on cobalt nanoparticles, chitosan and MWCNT for the determination of daclatasvir: a hepatitis C antiviral drug |
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