Induction of apoptosis by depletion of DNA topoisomerase IIα in mammalian cells

Inactivation of topoisomerase (topo) IIα arrests murine embryonic development. In topo IIα-depleted embryos, nuclei were partitioned to daughter cells without complete separation and formed an interconnecting droplet-like structure. The present study examined the fates of topo IIα-depleted cells wit...

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Veröffentlicht in:	Biochemical and biophysical research communications 2003-07, Vol.307 (2), p.301-307
Hauptverfasser:	Akimitsu, Nobuyoshi, Kamura, Koushirou, Toné, Shigenobu, Sakaguchi, Ayako, Kikuchi, Akihiko, Hamamoto, Hiroshi, Sekimizu, Kazuhisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Embryo ICRF-193 Knockout mouse siRNA
Online-Zugang:	Volltext
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