Macroporous hydrogels based on chitosan derivatives: Preparation, characterization, and in vitro evaluation
ABSTRACT Chitosan‐based hydrogels are considered as promising biomaterials for tissue engineering. Biological properties of chitosan could be significantly improved by modification of its chemical structure. This study was aimed at characterizing macroporous hydrogels fabricated by freeze‐drying tec...
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| Veröffentlicht in: | Journal of applied polymer science 2017-04, Vol.134 (13), p.np-n/a |
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| container_title | Journal of applied polymer science |
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| creator | Demina, Tatiana S. Zaytseva‐Zotova, Daria S. Akopova, Tatiana A. Zelenetskii, Alexander N. Markvicheva, Elena A. |
| description | ABSTRACT
Chitosan‐based hydrogels are considered as promising biomaterials for tissue engineering. Biological properties of chitosan could be significantly improved by modification of its chemical structure. This study was aimed at characterizing macroporous hydrogels fabricated by freeze‐drying technique from chitosan, which has been N‐acetylated by 2,2‐bis(hydroxymethyl)propionic acid or l,d‐lactide. The nature of the acetylated agent was shown to significantly affect hydrogels morphology, swelling behavior, zeta‐potential, and protein sorption as well as their degradation by lysozyme. According to scanning electron and confocal laser scanning microscopy, the hydrogels possessed interconnected macroporous network that facilitated cells penetration into the interior regions of the hydrogel. Chemical modification of chitosan significantly influenced L929 cell growth behavior on hydrogel compared to the non‐modified chitosan. The proposed chemical strategy for modification of chitosan could be considered as promising approach for improvement of chitosan hydrogels. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44651. |
| doi_str_mv | 10.1002/app.44651 |
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Chitosan‐based hydrogels are considered as promising biomaterials for tissue engineering. Biological properties of chitosan could be significantly improved by modification of its chemical structure. This study was aimed at characterizing macroporous hydrogels fabricated by freeze‐drying technique from chitosan, which has been N‐acetylated by 2,2‐bis(hydroxymethyl)propionic acid or l,d‐lactide. The nature of the acetylated agent was shown to significantly affect hydrogels morphology, swelling behavior, zeta‐potential, and protein sorption as well as their degradation by lysozyme. According to scanning electron and confocal laser scanning microscopy, the hydrogels possessed interconnected macroporous network that facilitated cells penetration into the interior regions of the hydrogel. Chemical modification of chitosan significantly influenced L929 cell growth behavior on hydrogel compared to the non‐modified chitosan. The proposed chemical strategy for modification of chitosan could be considered as promising approach for improvement of chitosan hydrogels. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44651.</description><identifier>ISSN: 0021-8995</identifier><identifier>EISSN: 1097-4628</identifier><identifier>DOI: 10.1002/app.44651</identifier><identifier>CODEN: JAPNAB</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc</publisher><subject>biocompatibility ; Chitosan ; Confocal ; Derivatives ; Hydrogels ; Materials science ; Morphology ; Networks ; Polymers ; polysaccharides ; Sorption ; Surgical implants ; synthesis and processing techniques</subject><ispartof>Journal of applied polymer science, 2017-04, Vol.134 (13), p.np-n/a</ispartof><rights>2016 Wiley Periodicals, Inc.</rights><rights>2017 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3671-8dbd0d81ae0d3acc532069da8707f3c936ef633fab4b7d3e3c1a75669e2b5c553</citedby><cites>FETCH-LOGICAL-c3671-8dbd0d81ae0d3acc532069da8707f3c936ef633fab4b7d3e3c1a75669e2b5c553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fapp.44651$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fapp.44651$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27926,27927,45576,45577</link.rule.ids></links><search><creatorcontrib>Demina, Tatiana S.</creatorcontrib><creatorcontrib>Zaytseva‐Zotova, Daria S.</creatorcontrib><creatorcontrib>Akopova, Tatiana A.</creatorcontrib><creatorcontrib>Zelenetskii, Alexander N.</creatorcontrib><creatorcontrib>Markvicheva, Elena A.</creatorcontrib><title>Macroporous hydrogels based on chitosan derivatives: Preparation, characterization, and in vitro evaluation</title><title>Journal of applied polymer science</title><description>ABSTRACT
Chitosan‐based hydrogels are considered as promising biomaterials for tissue engineering. Biological properties of chitosan could be significantly improved by modification of its chemical structure. This study was aimed at characterizing macroporous hydrogels fabricated by freeze‐drying technique from chitosan, which has been N‐acetylated by 2,2‐bis(hydroxymethyl)propionic acid or l,d‐lactide. The nature of the acetylated agent was shown to significantly affect hydrogels morphology, swelling behavior, zeta‐potential, and protein sorption as well as their degradation by lysozyme. According to scanning electron and confocal laser scanning microscopy, the hydrogels possessed interconnected macroporous network that facilitated cells penetration into the interior regions of the hydrogel. Chemical modification of chitosan significantly influenced L929 cell growth behavior on hydrogel compared to the non‐modified chitosan. The proposed chemical strategy for modification of chitosan could be considered as promising approach for improvement of chitosan hydrogels. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44651.</description><subject>biocompatibility</subject><subject>Chitosan</subject><subject>Confocal</subject><subject>Derivatives</subject><subject>Hydrogels</subject><subject>Materials science</subject><subject>Morphology</subject><subject>Networks</subject><subject>Polymers</subject><subject>polysaccharides</subject><subject>Sorption</subject><subject>Surgical implants</subject><subject>synthesis and processing techniques</subject><issn>0021-8995</issn><issn>1097-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kE1PwyAYx4nRxDk9-A1IvGhiNyiFFm_L4lsy4w56bihQ19mVCm3N_PQ-up1M5MLL__fAww-hc0omlJB4qtp2kiSC0wM0okSmUSLi7BCNIKNRJiU_RichrAmhlBMxQu9PSnvXOu_6gFdb492brQMuVLAGuwbrVdW5oBpsrK8G1VWDDTd46W2rPOxccw0ILHUH-df-RDUGVw0eqs47bAdV97_BKToqVR3s2X4eo9e725f5Q7R4vn-czxaRZiKFLk1hiMmossQwpTVnMRHSqCwlacm0ZMKWgrFSFUmRGmaZpirlQkgbF1xzzsbocndv691Hb0OXb6qgbV2rxsI3c5qlUmYZ2AH04g-6dr1voDug4GEYkgF1taNAVQjelnnrq43y25yS_Ed7DtrzX-3ATnfsZ1Xb7f9gPlsudxXfpguFtQ</recordid><startdate>20170405</startdate><enddate>20170405</enddate><creator>Demina, Tatiana S.</creator><creator>Zaytseva‐Zotova, Daria S.</creator><creator>Akopova, Tatiana A.</creator><creator>Zelenetskii, Alexander N.</creator><creator>Markvicheva, Elena A.</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope></search><sort><creationdate>20170405</creationdate><title>Macroporous hydrogels based on chitosan derivatives: Preparation, characterization, and in vitro evaluation</title><author>Demina, Tatiana S. ; Zaytseva‐Zotova, Daria S. ; Akopova, Tatiana A. ; Zelenetskii, Alexander N. ; Markvicheva, Elena A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3671-8dbd0d81ae0d3acc532069da8707f3c936ef633fab4b7d3e3c1a75669e2b5c553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>biocompatibility</topic><topic>Chitosan</topic><topic>Confocal</topic><topic>Derivatives</topic><topic>Hydrogels</topic><topic>Materials science</topic><topic>Morphology</topic><topic>Networks</topic><topic>Polymers</topic><topic>polysaccharides</topic><topic>Sorption</topic><topic>Surgical implants</topic><topic>synthesis and processing techniques</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Demina, Tatiana S.</creatorcontrib><creatorcontrib>Zaytseva‐Zotova, Daria S.</creatorcontrib><creatorcontrib>Akopova, Tatiana A.</creatorcontrib><creatorcontrib>Zelenetskii, Alexander N.</creatorcontrib><creatorcontrib>Markvicheva, Elena A.</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Journal of applied polymer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Demina, Tatiana S.</au><au>Zaytseva‐Zotova, Daria S.</au><au>Akopova, Tatiana A.</au><au>Zelenetskii, Alexander N.</au><au>Markvicheva, Elena A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Macroporous hydrogels based on chitosan derivatives: Preparation, characterization, and in vitro evaluation</atitle><jtitle>Journal of applied polymer science</jtitle><date>2017-04-05</date><risdate>2017</risdate><volume>134</volume><issue>13</issue><spage>np</spage><epage>n/a</epage><pages>np-n/a</pages><issn>0021-8995</issn><eissn>1097-4628</eissn><coden>JAPNAB</coden><abstract>ABSTRACT
Chitosan‐based hydrogels are considered as promising biomaterials for tissue engineering. Biological properties of chitosan could be significantly improved by modification of its chemical structure. This study was aimed at characterizing macroporous hydrogels fabricated by freeze‐drying technique from chitosan, which has been N‐acetylated by 2,2‐bis(hydroxymethyl)propionic acid or l,d‐lactide. The nature of the acetylated agent was shown to significantly affect hydrogels morphology, swelling behavior, zeta‐potential, and protein sorption as well as their degradation by lysozyme. According to scanning electron and confocal laser scanning microscopy, the hydrogels possessed interconnected macroporous network that facilitated cells penetration into the interior regions of the hydrogel. Chemical modification of chitosan significantly influenced L929 cell growth behavior on hydrogel compared to the non‐modified chitosan. The proposed chemical strategy for modification of chitosan could be considered as promising approach for improvement of chitosan hydrogels. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44651.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/app.44651</doi><tpages>7</tpages></addata></record> |
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| subjects | biocompatibility Chitosan Confocal Derivatives Hydrogels Materials science Morphology Networks Polymers polysaccharides Sorption Surgical implants synthesis and processing techniques |
| title | Macroporous hydrogels based on chitosan derivatives: Preparation, characterization, and in vitro evaluation |
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