On-chip integration of organic synthesis and HPLC/MS analysis for monitoring stereoselective transformations at the micro-scale
We present a microfluidic system, seamlessly integrating microflow and microbatch synthesis with a HPLC/nano-ESI-MS functionality on a single glass chip. The microfluidic approach allows to efficiently steer and dispense sample streams down to the nanoliter-range for studying reactions in quasi real...
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| Veröffentlicht in: | Lab on a chip 2017-01, Vol.17 (1), p.76-81 |
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| container_end_page | 81 |
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| container_issue | 1 |
| container_start_page | 76 |
| container_title | Lab on a chip |
| container_volume | 17 |
| creator | Heiland, Josef J Warias, Rico Lotter, Carsten Mauritz, Laura Fuchs, Patrick J W Ohla, Stefan Zeitler, Kirsten Belder, Detlev |
| description | We present a microfluidic system, seamlessly integrating microflow and microbatch synthesis with a HPLC/nano-ESI-MS functionality on a single glass chip. The microfluidic approach allows to efficiently steer and dispense sample streams down to the nanoliter-range for studying reactions in quasi real-time. In a proof-of-concept study, the system was applied to explore amino-catalyzed reactions, including asymmetric iminium-catalyzed Friedel-Crafts alkylations in microflow and micro confined reaction vessels. |
| doi_str_mv | 10.1039/c6lc01217e |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1473-0197 |
| ispartof | Lab on a chip, 2017-01, Vol.17 (1), p.76-81 |
| issn | 1473-0197 1473-0189 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1879984419 |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Asymmetry Chips Microfluidics Monitoring Nanostructure Streams Synthesis Transformations |
| title | On-chip integration of organic synthesis and HPLC/MS analysis for monitoring stereoselective transformations at the micro-scale |
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