The safety of aerosolized diethylenetriamine nitric oxide adduct after single-dose administration to anesthetized piglets and multiple-dose administration to conscious rats

Diethylenetriamine nitric oxide adduct (DETA/NO) is a slow-release NO donor. It has been shown to be a selective pulmonary vasodilator in acute pulmonary hypertension. However, its potential toxicity after inhalation is unknown. This study investigated the potential toxicity of aerosolized DETA/NO a...

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Veröffentlicht in:	Toxicology and applied pharmacology 2003-07, Vol.190 (1), p.65-71
Hauptverfasser:	Lam, Chen-Fuh, Caterina, Paul, Filion, Pierre, Ilett, Kenneth F., van Heerden, Peter V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Aerosols Anesthesia Animals Biological and medical sciences Drug toxicity and drugs side effects treatment Guinea Pigs Lung Diseases - chemically induced Lung Diseases - pathology Male Medical sciences Methemoglobin - metabolism Microscopy, Electron, Scanning Transmission Miscellaneous (drug allergy, mutagens, teratogens...) Neutrophils - drug effects Neutrophils - metabolism Nitric Oxide - chemistry Nitric Oxide Donors - administration & dosage Nitric Oxide Donors - blood Nitric Oxide Donors - toxicity Nitrites - blood Organ Size - drug effects Pharmacology. Drug treatments Polyamines - administration & dosage Polyamines - blood Polyamines - toxicity Pulmonary Surfactant-Associated Protein B - metabolism Rats Rats, Wistar Swine Trachea - drug effects Trachea - pathology
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