Multicenter dose-finding study of concurrent capecitabine and radiotherapy as adjuvant treatment for operable rectal cancer

5-Fluorouracil–based chemotherapy with concurrent radiotherapy (RT) is the standard adjuvant treatment in rectal cancer. A Phase I study was conducted to determine the maximal tolerated dose and the dose-limiting toxicities of capecitabine combined with standard RT as adjuvant treatment in patients...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2003-08, Vol.56 (5), p.1284-1287
Hauptverfasser:	Souglakos, John, Androulakis, Nikolaos, Mavroudis, Dimitrios, Kourousis, Charalabos, Kakolyris, Stylianos, Vardakis, Nikolaos, Kalbakis, Konstantinos, Pallis, Athanasios, Ardavanis, Alexandros, Varveris, Charalabos, Georgoulias, Vassilios
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant treatment Adult Aged Antimetabolites, Antineoplastic - therapeutic use Biological and medical sciences Capecitabine Combined Modality Therapy Deoxycytidine - adverse effects Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use Dose-Response Relationship, Drug Female Fluorouracil - analogs & derivatives Humans Male Medical sciences Middle Aged Radiotherapy Rectal cancer Rectal Neoplasms - therapy
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