The role of mobile genetic elements in bacterial adaptation to xenobiotic organic compounds
Retrospective studies clearly indicate that mobile genetic elements (MGEs) play a major role in the in situ spread and even de novo construction of catabolic pathways in bacteria, allowing bacterial communities to rapidly adapt to new xenobiotics. The construction of novel pathways seems to occur by...
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| Veröffentlicht in: | Current opinion in biotechnology 2003-06, Vol.14 (3), p.262-269 |
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| creator | Top, Eva M Springael, Dirk |
| description | Retrospective studies clearly indicate that mobile genetic elements (MGEs) play a major role in the
in situ spread and even
de novo construction of catabolic pathways in bacteria, allowing bacterial communities to rapidly adapt to new xenobiotics. The construction of novel pathways seems to occur by an assembly process that involves horizontal gene transfer: different appropriate genes or gene modules that encode different parts of the novel pathway are recruited from phylogenetically related or distant hosts into one single host. Direct evidence for the importance of catabolic MGEs in bacterial adaptation to xenobiotics stems from observed correlations between catabolic gene transfer and accelerated biodegradation in several habitats and from studies that monitor catabolic MGEs in polluted sites. |
| doi_str_mv | 10.1016/S0958-1669(03)00066-1 |
| format | Article |
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| ispartof | Current opinion in biotechnology, 2003-06, Vol.14 (3), p.262-269 |
| issn | 0958-1669 1879-0429 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adaptation, Physiological - genetics Bacteria - genetics Bacteria - metabolism Biodegradation, Environmental Catalysis Environmental Pollutants - metabolism Evolution, Molecular Gene Expression Regulation, Bacterial - genetics Gene Transfer, Horizontal - genetics Interspersed Repetitive Sequences - genetics Xenobiotics - metabolism |
| title | The role of mobile genetic elements in bacterial adaptation to xenobiotic organic compounds |
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