Effects of Oxidative and Nitrative Challenges on α-Synuclein Fibrillogenesis Involve Distinct Mechanisms of Protein Modifications

Filamentous inclusions of α-synuclein protein are hallmarks of neurodegenerative diseases collectively known as synucleinopathies. Previous studies have shown that exposure to oxidative and nitrative species stabilizes α-synuclein filaments in vitro, and this stabilization may be due to dityrosine c...

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Veröffentlicht in:	The Journal of biological chemistry 2003-07, Vol.278 (29), p.27230-27240
Hauptverfasser:	Norris, Erin H., Giasson, Benoit I., Ischiropoulos, Harry, Lee, Virginia M.-Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein Cell Line Cross-Linking Reagents Drug Stability Humans In Vitro Techniques Inclusion Bodies - metabolism Microscopy, Electron Models, Biological Mutagenesis, Site-Directed Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nitrates - metabolism Oxidation-Reduction Oxidative Stress Protein Processing, Post-Translational Protein Structure, Quaternary Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Synucleins Tyrosine - chemistry
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